APLF
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Official Full Name
aprataxin and PNKP like factor
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Overview
C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007;(PubMed 17353262)). -
Synonyms
APLF; aprataxin and PNKP like factor; C2orf13, chromosome 2 open reading frame 13; aprataxin and PNK-like factor; MGC47799; XRCC1-interacting protein 1; PNK and APTX-like FHA protein; aprataxin- and PNK-like factor; apurinic-apyrimidinic endonuclease APL;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Human
- Mouse
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- DDK
- GST
- His
- His (Fc)
- Avi
- Myc
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
APLF involved in several pathways and played different roles in them. We selected most pathways APLF participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APLF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
APLF has several biochemical functions, for example, 3-5 exonuclease activity, DNA-(apurinic or apyrimidinic site) lyase activity, endodeoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APLF itself. We selected most functions APLF had, and list some proteins which have the same functions with APLF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-5 exonuclease activity | RAD9A;EXOSC10;APLF;RAD1;POLG;RAD9B;MRE11A;EXD1;TREX1 |
| DNA-(apurinic or apyrimidinic site) lyase activity | HMGA2;HMGA1B;HMGA1;HMGA1-RS1;APEX2;HMGA1A;NEIL3;NTHL1;RPS3 |
| endodeoxyribonuclease activity | ZRANB3;DNASE1;DNASE1L3;ERCC5;MRE11A;DNASE1L1;RPS3;APEX1;DNASE1L3L |
| metal ion binding | ZDHHC3B;ZFP653;CYBA;SALL4;PTGS1;AMDHD1;ZNF792;PDE8A;HBBE3 |
| nucleotide binding | ROCK2B;SRSF12;DOM3Z;KITB;NTRK3A;FYNA;CAMK2D1;ACTA1B;ABCA13 |
| protein binding | RBM4;NPY2R;CTSB;ITGB2;PDGFRA;CDK9;PIK3C2B;ARPC2;EPM2A |
APLF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APLF here. Most of them are supplied by our site. Hope this information will be useful for your research of APLF.
XRCC1; XRCC4; XRCC5
- Q&As
- Reviews
Q&As (19)
Ask a questionAPLF may play a role in adjuvant therapy or targeted therapy in the treatment of immune deficiency diseases.
APLF may be expressed differently in some cancer cells.
APLF may play different mechanisms of action in different cancers, and further research is needed.
APLF is a reaction factor for the single strand structure of DNA.
The expression level of APLF is different in different tissues.
APLF is an important factor in the repair process of DNA double-strand breaks after DNA damage.
APLF may play a role in adjuvant therapy or targeted therapy in cancer therapy.
APLF may play an important role in the process of DNA single strand cleavage repair.
Recombinant APLF proteins may affect the efficiency or manner in which DNA damage is repaired.
APLF may play a role in adjuvant therapy or targeted therapy in tumor immunotherapy.
APLF can be prepared by genetic engineering and other technologies.
The functional mechanism of APLF includes interaction with other molecules.
APLF plays an important role in DNA repair, apoptosis, cell cycle and other processes.
APLF may be a potential prognostic marker in tumor prognosis and needs to be further validated.
APLF may have synergistic effects on drug therapy.
APLF is related to signal transduction pathways such as PI3K-Akt signaling pathway and NF-κB signaling pathway.
APLF is associated with certain cancers, immune deficiency diseases and other diseases.
The structural characteristics of APLF s include the presence of nucleotide binding sites.
APLF may play an important role in cell apoptosis.
Customer Reviews (4)
Write a reviewThe strip shape of APLF in Western blot is regular, indicating that it has excellent uniformity and predictability.
After using APLF, the sensitivity of the experiment was significantly improved.
The production process of APLF fully reflects the concept of green and environmental protection and contributes to sustainable development.
It can maintain stable performance even after multiple uses, which makes me more confident in the experimental results.
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