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APPBP2

  • Official Full Name

    amyloid beta precursor protein (cytoplasmic tail) binding protein 2

  • Overview

    The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimers disease. This gene has been found to be highly expressed in breast cancer. Multiple polyadenylation sites have been found for this gene.
  • Synonyms

    APPBP2; amyloid beta precursor protein (cytoplasmic tail) binding protein 2; amyloid protein-binding protein 2; Hs.84084; KIAA0228; PAT1; protein interacting with APP tail 1; Amyloid protein binding protein 2; APP BP2; APP-BP2; amyloid beta precursor protein-binding protein 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human APPBP2-723H Recombinant Human APPBP2 protein, GST-tagged Wheat Germ GST
Human APPBP2-100HCL Recombinant Human APPBP2 cell lysate N/A
Human APPBP2-2757H Recombinant Human APPBP2 protein, His-tagged E.coli His 288-586 aa
Human APPBP2-1123HF Recombinant Full Length Human APPBP2 Protein, GST-tagged In Vitro Cell Free System GST 585 amino acids
Mouse APPBP2-1813M Recombinant Mouse APPBP2 Protein Mammalian Cell His
Mouse APPBP2-644M Recombinant Mouse APPBP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse APPBP2-644M-B Recombinant Mouse APPBP2 Protein Pre-coupled Magnetic Beads HEK293
Rat Appbp2-3442R Recombinant Rat Appbp2, His-tagged E.Coli or Yeast His 585
Rat APPBP2-732R Recombinant Rat APPBP2 Protein Mammalian Cell His
Rat Appbp2-8170R Recombinant Rat Appbp2 protein, His & T7-tagged E.coli His/T7 Lys396~Cys585
Rat APPBP2-388R-B Recombinant Rat APPBP2 Protein Pre-coupled Magnetic Beads HEK293
Rat APPBP2-388R Recombinant Rat APPBP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque APPBP2-369R Recombinant Rhesus monkey APPBP2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque APPBP2-198R-B Recombinant Rhesus Macaque APPBP2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque APPBP2-198R Recombinant Rhesus Macaque APPBP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish APPBP2-11911Z Recombinant Zebrafish APPBP2 Mammalian Cell His
Chicken APPBP2-2424C Recombinant Chicken APPBP2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

APPBP2 involved in several pathways and played different roles in them. We selected most pathways APPBP2 participated on our site, such as Regulation of Androgen receptor activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with APPBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Regulation of Androgen receptor activityNR0B1;HOXB13;SRY;TRIM24;SENP1;KAT7;NR2C2;SMARCE1;APPBP2

APPBP2 has several biochemical functions, for example, microtubule motor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APPBP2 itself. We selected most functions APPBP2 had, and list some proteins which have the same functions with APPBP2. You can find most of the proteins on our site.

Function Related Protein
microtubule motor activityKIF5C;KIF20A;KIF7;KIF2C;BBS4;KIF3B;DYNC1I2;DNAH11;KIF2A
protein bindingBTG2;NDUFB11;DDX11;LDHA;NLRP2;KRTAP8-1;TPD52;RXRG;HSD17B10

APPBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APPBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APPBP2.

FSTL1; TBL3; RRS1; WDR24; NFYA

  • Q&As
  • Reviews

Q&As (17)

Ask a question
Is APPBP2 solely associated with Alzheimer's disease, or does it have other functions? 03/04/2023

APPBP2 has been reported to have additional functions beyond Alzheimer's disease. It is involved in various cellular processes such as neuronal development, synaptic function, and gene transcription. Additionally, it interacts with other proteins to regulate different signaling pathways in the brain. Its role in these processes warrants further investigation.

What are the implications of APPBP2 dysfunction? 11/08/2022

Dysregulation of APPBP2 or alterations in its interactions with other proteins can disrupt normal cellular processes, potentially leading to neurological disorders. Dysfunction of APPBP2 has been implicated in Alzheimer's disease and other neurodegenerative conditions, highlighting its significance in maintaining proper brain function.

Can APPBP2 be targeted for diagnostic purposes or early detection of neurodegenerative diseases? 10/31/2021

Research is ongoing to assess the potential of APPBP2 as a diagnostic biomarker for neurodegenerative diseases. Its detection in cerebrospinal fluid suggests it may have diagnostic utility, but further studies are needed to establish its sensitivity, specificity, and reliability as a diagnostic tool.

What are some proteins that interact with APPBP2? 08/05/2021

Besides interacting with APP, APPBP2 has been found to interact with proteins such as APLP1 (Amyloid precursor-like protein 1), APLP2, Mint/X11 proteins, JIP1, and JIP2. These interactions contribute to the regulation of APP processing, synaptic function, and neuronal development.

Are there any therapeutic implications of APPBP2 in Alzheimer's disease? 06/13/2021

APPBP2 represents a potential therapeutic target for Alzheimer's disease due to its involvement in APP processing and amyloid beta production. However, more research is needed to fully elucidate the mechanisms and determine the feasibility of targeting APPBP2 for therapeutic interventions.

Is APPBP2 expressed in all tissues or specific to the brain? 12/19/2020

APPBP2 is widely expressed in various tissues throughout the body, but it is particularly abundant in the brain. Its high expression in the brain highlights its potential importance in neuronal function and neurodegenerative diseases like Alzheimer's.

How is APPBP2 involved in the pathogenesis of Alzheimer's disease? 10/18/2020

APPBP2 plays a role in the processing of amyloid precursor protein (APP), which is central to the formation of amyloid-beta plaques, a hallmark of Alzheimer's disease. APPBP2 interacts with APP and regulates its degradation, metabolism, and trafficking. Dysregulation of APPBP2 can lead to increased production of toxic forms of amyloid-beta, contributing to the pathogenesis of Alzheimer's.

Can APPBP2 be targeted for therapeutic interventions in Alzheimer's disease? 06/22/2019

The potential of targeting APPBP2 for therapeutic interventions in Alzheimer's disease is being investigated. Modulating APPBP2's interactions with APP and other proteins involved in APP processing could be a strategy to reduce the production of amyloid-beta or enhance its clearance. However, more research is needed to validate this approach and explore its safety and efficacy.

Is there any link between APPBP2 and other neurodegenerative diseases? 03/23/2019

APPBP2 has been implicated in other neurodegenerative diseases besides Alzheimer's, including Parkinson's disease and Huntington's disease. It interacts with proteins involved in the pathogenesis of these diseases and may contribute to their progression. Further research is needed to fully understand the role of APPBP2 in these conditions.

Are there any genetic variants or mutations in the APPBP2 gene associated with Alzheimer's disease? 12/22/2018

Some genetic studies have identified variants in the APPBP2 gene that may be associated with an increased risk of developing Alzheimer's disease. However, further research is needed to fully understand the implications of these genetic variations and their relationship to the disease.

How does APPBP2 regulate APP processing? 11/27/2018

APPBP2 interacts with the cytoplasmic domain of APP and influences its trafficking and processing. It can facilitate the internalization of APP, affecting its subsequent cleavage by secretases, enzymes that generate amyloid beta peptides.

Does APPBP2 play a role in Alzheimer's disease? 09/07/2018

The exact role of APPBP2 in Alzheimer's disease is not completely understood. However, studies have suggested that alterations in APPBP2 expression or function may contribute to the pathogenesis of the disease. Dysregulation of APPBP2 could potentially affect APP processing, leading to the accumulation of amyloid beta peptides, a hallmark of Alzheimer's disease.

Can APPBP2 be detected in cerebrospinal fluid or blood samples? 11/04/2017

Studies have shown that APPBP2 levels can be measured in cerebrospinal fluid, suggesting its potential as a biomarker for neurodegenerative diseases. However, more research is needed to validate its utility as a diagnostic or prognostic biomarker.

Are there any ongoing research studies or clinical trials targeting APPBP2? 09/23/2017

At present, there are limited clinical trials specifically targeting APPBP2 for therapeutic purposes. However, ongoing research aims to further understand the role of APPBP2 in Alzheimer's disease and explore its potential as a therapeutic target.

Are there any experimental techniques to study APPBP2? 07/13/2017

Several techniques can be used to study APPBP2, including co-immunoprecipitation assays, proximity-dependent labeling methods, live-cell imaging, knockout or knockdown experiments, and biochemical assays to assess protein-protein interactions and functional consequences.

Are there any known genetic variations or mutations in APPBP2 associated with neurodegenerative diseases? 06/27/2017

While there are currently no well-established genetic variations or mutations in APPBP2 directly associated with neurodegenerative diseases, altered expression levels and functional changes in APPBP2 have been observed in Alzheimer's and other neurodegenerative conditions. These alterations could be influenced by genetic or epigenetic factors and contribute to disease pathology.

Are there any known inhibitors or activators of APPBP2? 04/12/2017

Currently, there are no known specific inhibitors or activators of APPBP2. However, compounds targeting other proteins involved in APP processing, such as gamma-secretase inhibitors or modulators, are being explored in the context of Alzheimer's disease treatment.

Customer Reviews (4)

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Reviews
11/22/2022

    the APPBP2 protein's high quality, dependable performance, and comprehensive technical support make it an excellent choice for researchers seeking to investigate angiopoietin-related biology and unravel the complexities of vascular development and pathogenesis.

    08/09/2019

      the APPBP2 protein's versatility extends beyond its proven usefulness in in vitro experiments.

      07/21/2019

        Its versatility allows researchers to explore APPBP2's involvement in diverse biological processes and fully uncover its functional role.

        02/17/2019

          It can also be employed in various molecular biology techniques, such as Western blotting, immunoprecipitation, or protein-protein interaction studies.

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