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APRT

  • Official Full Name

    adenine phosphoribosyltransferase

  • Overview

    Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    APRT; adenine phosphoribosyltransferase; AMP; AMP diphosphorylase; AMP pyrophosphorylase; APT_HUMAN; DKFZp686D13177; MGC125856; MGC125857; MGC129961; Transphosphoribosidase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human APRT-1939H Recombinant Human Adenine phosphoribosyltransferase E.coli N/A
Human APRT-20H Recombinant Human APRT protein, His-tagged E.coli His 195aa(including fusion tag)
Human APRT-132H Recombinant Human APRT protein, MYC/DDK-tagged HEK293 Myc/DDK
Human APRT-591H Recombinant Human APRT protein, His-tagged E.coli His Met1~Glu180
Human APRT-729H Recombinant Human APRT protein, GST-tagged Wheat Germ GST
Human APRT-102HCL Recombinant Human APRT cell lysate N/A
Human APRT-6499H Recombinant Human APRT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human APRT-1830H Recombinant Human APRT protein, GST-tagged E.coli GST 1-180 aa
Human APRT-8029HFL Recombinant Full Length Human APRT protein, Flag-tagged Mamanlian cells Flag
Human APRT-0592H Recombinant Human APRT Protein (Met1-Glu180), N-His-tagged E.coli N-His Met1-Glu180
Human APRT-1154HF Recombinant Full Length Human APRT Protein, GST-tagged In Vitro Cell Free System GST 180 amino acids
Mouse Aprt-3152M Recombinant Mouse Aprt, His-tagged E.Coli or Yeast His 180
Mouse Aprt-1669M Recombinant Mouse Aprt Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat APRT-733R Recombinant Rat APRT Protein Mammalian Cell His
Rat APRT-389R Recombinant Rat APRT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat APRT-389R-B Recombinant Rat APRT Protein Pre-coupled Magnetic Beads HEK293
Zebrafish APRT-10937Z Recombinant Zebrafish APRT Mammalian Cell His
Chicken APRT-5028C Recombinant Chicken APRT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • APRT Related Articles

APRT involved in several pathways and played different roles in them. We selected most pathways APRT participated on our site, such as Purine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with APRT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismPRIM2;PDE7B;PFAS;PRPS2;AK7B;PDE6H;POLR2B;FHIT;TWISTNB
Metabolic pathwaysADK;GART;AZIN2;PAFAH1B1A;GBGT1L4;ACSBG1;HSD3B2;DGAT1A;OLAH

APRT has several biochemical functions, for example, AMP binding, adenine binding, adenine phosphoribosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APRT itself. We selected most functions APRT had, and list some proteins which have the same functions with APRT. You can find most of the proteins on our site.

Function Related Protein
AMP bindingPRPS1;APRT;PRPS2;ACSS2;PYGL;PRKAG1;CYB5R3;PRKAG2;PYGM
adenine binding
adenine phosphoribosyltransferase activity

APRT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APRT here. Most of them are supplied by our site. Hope this information will be useful for your research of APRT.

GH1; MCC; VHL; IKBKE; FTSJ1; TRAF6; MLH1; VCAM1

Zarella-Boitz, JM; Rager, N; et al. Subcellular localization of adenine and xanthine phosphoribosyltransferases in Leishmania donovani. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 134:43-51(2004).
Myohanen, S; Baylin, SB; et al. Sequence-specific DNA binding activity of RNA helicase A to the p16(INK4a) promoter. JOURNAL OF BIOLOGICAL CHEMISTRY 276:1634-1642(2001).
  • Q&As
  • Reviews

Q&As (22)

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What are the symptoms of APRT deficiency? 08/17/2022

The symptoms of APRT deficiency may include recurrent kidney stones, abdominal pain, blood in the urine (hematuria), urinary tract infections, and, in some cases, kidney damage or failure.

Are there any support groups or resources available for individuals with APRT deficiency? 07/06/2022

There are several support groups and resources available for individuals and families affected by APRT deficiency. Examples include the APRT Deficiency Foundation and various online communities where individuals can connect, share experiences, and access information and support.

Are there any medications or substances that individuals with APRT deficiency should avoid? 08/24/2021

Individuals with APRT deficiency should avoid medications that can increase the production or accumulation of adenine, such as certain diuretics, chemotherapy drugs, and supplements containing high levels of adenine or purines.

Is APRT deficiency a treatable condition? 07/04/2021

Yes, APRT deficiency can be managed through dietary modifications, medication (such as allopurinol to reduce adenine levels), and the prevention or treatment of kidney stones. In severe cases, kidney transplant may be necessary.

Can APRT deficiency be inherited? 06/30/2021

Yes, APRT deficiency is an inherited condition caused by mutations in the APRT gene. It follows an autosomal recessive pattern of inheritance, meaning that individuals need to inherit two copies of the mutated gene (one from each parent) to develop the condition.

How is APRT deficiency diagnosed? 12/12/2020

APRT deficiency can be diagnosed through laboratory tests, such as measuring the levels of APRT enzyme activity in the blood or urine, and genetic testing to identify mutations in the APRT gene.

Is APRT deficiency more common in certain populations or ethnicities? 10/10/2020

APRT deficiency has been reported in various population groups, but its prevalence may vary among different ethnicities. For example, the condition appears to be more common in individuals of Japanese descent compared to other populations.

What happens if the APRT protein is deficient or dysfunctional? 08/10/2020

If the APRT protein is deficient or dysfunctional, it can lead to a rare genetic disorder called APRT deficiency. This condition can result in the accumulation of excessive amounts of adenine in the body, leading to the formation of kidney stones and other health problems.

Can APRT deficiency be detected prenatally? 01/23/2020

Yes, prenatal diagnosis of APRT deficiency is possible through genetic testing. This can be performed through chorionic villus sampling or amniocentesis to analyze the DNA of the fetus and determine if they have inherited the mutated APRT gene.

Are there any ongoing research efforts or clinical trials for APRT deficiency? 08/06/2019

Yes, there are ongoing research efforts and clinical trials focused on understanding APRT deficiency, developing improved diagnostic methods, and exploring potential treatment options. These studies aim to further our knowledge and improve care for individuals with the condition.

What are the symptoms of APRT deficiency? 06/30/2019

The most common symptom of APRT deficiency is the formation of kidney stones made of 2,8-dihydroxyadenine, which can cause severe pain and discomfort. Other symptoms may include blood in the urine, urinary tract infections, and occasionally, kidney damage or kidney failure.

Are there any ongoing studies or research related to the APRT protein? 05/18/2019

Research on APRT deficiency and the APRT protein continues to advance, focusing on understanding the underlying mechanisms of the disorder, developing better diagnostic methods, and exploring potential novel treatment approaches.

Are there any known variations or mutations of the APRT protein? 04/06/2019

Yes, mutations in the APRT gene can lead to APRT deficiency. There are several known genetic variants that can affect the function of the APRT protein and contribute to the development of the disorder.

Can APRT deficiency be prevented? 02/27/2019

APRT deficiency cannot be prevented since it is an inherited condition. However, genetic counseling and testing can help assess the risk of passing on the condition and guide family planning decisions.

Can lifestyle changes help individuals with APRT deficiency? 08/12/2018

Making certain lifestyle changes can help individuals with APRT deficiency. These may include maintaining good hydration, following a balanced diet to manage purine intake, and avoiding medications that may exacerbate kidney stone formation.

Can APRT deficiency be cured? 07/13/2018

Currently, there is no known cure for APRT deficiency. However, with proper management and treatment, the symptoms and complications can be controlled, allowing individuals to lead relatively normal lives.

How does the APRT protein facilitate the conversion of adenine to AMP? 05/16/2018

The APRT protein utilizes the enzyme activity of phosphoribosyltransferase to transfer a phosphoribosyl group from phosphoribosyl pyrophosphate (PRPP) to adenine. This results in the formation of AMP and pyrophosphate.

How common is APRT deficiency? 01/21/2018

APRT deficiency is considered to be a rare disorder, with its prevalence varying among different populations. It is estimated to affect approximately 1 in 100,000 to 200,000 individuals globally.

Are there any other known functions or roles of the APRT protein? 01/16/2018

Currently, the primary known function of the APRT protein is its role in the adenine metabolism pathway. However, further research may identify additional roles or functions associated with this protein.

Can APRT deficiency affect other organs or systems besides the kidneys? 02/16/2017

While the primary manifestation of APRT deficiency is the formation of kidney stones, there have been reports of abnormalities in other body systems, such as the liver and skeletal system. However, these occurrences are relatively rare and not typically seen in all individuals with the condition.

Can APRT deficiency have long-term complications? 09/16/2016

Yes, untreated or poorly managed APRT deficiency can lead to recurrent kidney stones, which may cause kidney damage or even kidney failure if left untreated. It is important to diagnose and manage the condition to prevent such complications.

What treatments are available for APRT deficiency? 05/12/2016

The treatment of APRT deficiency primarily involves managing and preventing the formation of kidney stones. This may include increasing fluid intake, taking medications to reduce the production of 2,8-dihydroxyadenine, and avoiding certain foods high in purines. In severe cases, surgical intervention may be necessary to remove kidney stones.

Customer Reviews (4)

Write a review
Reviews
03/21/2020

    This collaborative partnership contributes to a productive and efficient research experience, as I can rely on their expertise and assistance throughout the process.

    10/30/2019

      The manufacturer's excellent technical support, commitment to innovation, and customer-centric approach position them as an invaluable resource.

      10/09/2018

        the APRT protein is of exceptional quality, perfectly suiting my experimental needs.

        11/26/2016

          They actively listen to my experimental needs and tailor their services accordingly, recognizing the unique requirements of my research.

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