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AQP3

  • Official Full Name

    Aquaporin 3 (Gill Blood Group)

  • Overview

    Aquaporin 3 is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells. This protein is also a determinant for the GIL blood group system.
  • Synonyms

    AQP3; aquaporin 3 (Gill blood group); GIL; AQP-3; aquaporin-3; aquaglyceroporin-3; aquaporin 3 (GIL blood group); aquaporin 3; OTTHUMP00000021206; Gill blood group;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Homo sapiens (Human)
  • Human
  • Milnesium tardigradum (Water bear) (Tardigrade)
  • Mouse
  • Mus musculus (Mouse)
  • Pig
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • GST
  • Tag
  • Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AQP3-465H Recombinant Human AQP3 Mammalian Cell His
Human AQP3-8767HCL Recombinant Human AQP3 293 Cell Lysate HEK293 N/A
Human AQP3-6031H Recombinant Human AQP3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AQP3-289HFL Active Recombinant Full Length Human AQP3 Protein, C-Flag-tagged Mammalian cells Flag
Human AQP3-368H-B Recombinant Human AQP3 Protein Pre-coupled Magnetic Beads HEK293
Human AQP3-368H Recombinant Human AQP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse AQP3-1822M Recombinant Mouse AQP3 Protein Mammalian Cell His
Mouse Aqp3-1671M Recombinant Mouse Aqp3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse AQP3-649M-B Recombinant Mouse AQP3 Protein Pre-coupled Magnetic Beads HEK293
Mouse AQP3-649M Recombinant Mouse AQP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Aqp3-235M Recombinant Mouse Aqp3 Protein, His&GST-tagged E.coli N-His&GST Asn83-Gln291
Rat Aqp3-3598R Recombinant Rat Aqp3, His-tagged E.Coli or Yeast His 292
Bos taurus (Bovine) RFL1687BF Recombinant Full Length Bovine Aquaporin-3(Aqp3) Protein, Tag-Free E.coli expression system Tag-Free Full Length (1-292)
Homo sapiens (Human) RFL6229HF Recombinant Full Length Human Aquaporin-3(Aqp3) Protein, His-Tagged E.coli expression system His Full Length (1-292)
Milnesium tardigradum (Water bear) (Tardigrade) RFL15216MF Recombinant Full Length Milnesium Tardigradum Aquaporin-3(Aqp3) Protein, Tag-Free E.coli expression system Tag-Free Full Length (1-326)
Mus musculus (Mouse) RFL12661MF Recombinant Full Length Mouse Aquaporin-3(Aqp3) Protein, His-Tagged E.coli expression system His Full Length (1-292)
Rattus norvegicus (Rat) RFL-19751RF Recombinant Full Length Rat Aquaporin-3(Aqp3) Protein, His-Tagged E.coli expression system His Full Length (1-292)
Rhesus Macaque AQP3-373R Recombinant Rhesus monkey AQP3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque AQP3-202R Recombinant Rhesus Macaque AQP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque AQP3-202R-B Recombinant Rhesus Macaque AQP3 Protein Pre-coupled Magnetic Beads HEK293
Sus scrofa (Pig) RFL-7090SF Recombinant Full Length Pig Aquaporin-3(Aqp3) Protein, His-Tagged E.coli expression system His Full Length (1-290)
Pig AQP3-3599P Recombinant Pig AQP3, His-tagged E.Coli or Yeast His 290
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AQP3 Related Articles

AQP3 involved in several pathways and played different roles in them. We selected most pathways AQP3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AQP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

AQP3 has several biochemical functions, for example, glycerol channel activity, transporter activity, urea transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AQP3 itself. We selected most functions AQP3 had, and list some proteins which have the same functions with AQP3. You can find most of the proteins on our site.

Function Related Protein
glycerol channel activityAQP8A.1;AQP1A.2;AQP5;AQP6;AQP1A.1;MIP;AQP4;AQP3A;AQP8A.2
transporter activitySLC22A1;SLC25A38;SLC12A2;FABP6;LCN15;RLBP1A;RBP7;SLC2A3A;NUP153
urea transmembrane transporter activityAQP8A.2;AQP10;AQP7;AQP10B;AQP10A;AQP3A;AQP9B;AQP9;AQP8A.1
water channel activityAQP8;AQP10A;AQP4;AQP1;AQP9B;AQP8B;AQP7;AQP1A.1;AQP3A

AQP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AQP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of AQP3.

rhlE

Tran, TL; Bek, T; et al. Altered aquaporin expression in glaucoma eyes. APMIS 122:772-780(2014).
Marlar, S; Arnspang, EC; et al. Elevated cAMP increases aquaporin-3 plasma membrane diffusion. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 306:C598-C606(2014).
  • Q&As
  • Reviews

Q&As (20)

Ask a question
Are there any known disorders or conditions associated with AQP3 dysfunction? 01/27/2023

Yes, mutations or alterations in the AQP3 gene have been associated with several skin disorders, including palmoplantar keratoderma and porokeratosis. These conditions are characterized by abnormal skin thickening and the formation of scaly patches.

Is genetic testing available for AQP3-related disorders? 12/19/2022

Yes, genetic testing can be conducted to identify mutations in the AQP3 gene that may be associated with specific skin disorders. This testing can help with diagnosis and provide valuable information for understanding the underlying cause of the condition.

Can lifestyle factors or environmental factors affect AQP3 activity? 08/26/2022

Yes, certain lifestyle factors and environmental conditions can influence AQP3 activity. For example, exposure to ultraviolet radiation from sunlight can upregulate AQP3 expression in the skin, potentially affecting skin hydration and barrier function. Additionally, some studies suggest that certain drugs, such as retinoids, may modulate AQP3 expression and function.

Can AQP3 dysfunction lead to any other health issues? 05/27/2022

AQP3 dysfunction may be involved in the development of some metabolic disorders and certain types of cancer. Dysregulation of AQP3 expression or activity has been linked to altered water transport and cell proliferation, which can contribute to disease progression.

Does AQP3 play a role in the regulation of body temperature? 06/14/2021

While AQP3 primarily functions as a water transporter, there is evidence suggesting its involvement in thermoregulation. Studies have shown that AQP3 expression increases in response to heat exposure, and it may facilitate the movement of water and thermal energy across the skin, contributing to cooling mechanisms in the body.

Does AQP3 play a role in the regulation of body temperature? 06/14/2021

While AQP3 primarily functions as a water transporter, there is evidence suggesting its involvement in thermoregulation. Studies have shown that AQP3 expression increases in response to heat exposure, and it may facilitate the movement of water and thermal energy across the skin, contributing to cooling mechanisms in the body.

Can AQP3 be targeted for therapeutic purposes? 02/07/2021

AQP3 has been investigated as a potential therapeutic target in various contexts. For example, in dermatology, compounds that modulate AQP3 activity are being explored for their ability to improve skin hydration and barrier function. In cancer research, inhibiting AQP3 expression or activity has shown potential in impeding tumor growth and metastasis.

Can AQP3 be targeted for therapeutic purposes? 02/07/2021

AQP3 has been investigated as a potential therapeutic target in various contexts. For example, in dermatology, compounds that modulate AQP3 activity are being explored for their ability to improve skin hydration and barrier function. In cancer research, inhibiting AQP3 expression or activity has shown potential in impeding tumor growth and metastasis.

Can AQP3 dysfunction affect the hydration of the skin? 08/21/2020

Yes, alterations in AQP3 function or expression can impact skin hydration. Decreased AQP3 activity has been associated with impaired water transport across skin cells, leading to decreased skin hydration and potentially contributing to dry skin conditions.

Can AQP3 dysfunction affect the hydration of the skin? 08/21/2020

Yes, alterations in AQP3 function or expression can impact skin hydration. Decreased AQP3 activity has been associated with impaired water transport across skin cells, leading to decreased skin hydration and potentially contributing to dry skin conditions.

Are there any treatments available for AQP3-related disorders? 05/08/2020

Currently, there are no specific targeted treatments available for AQP3-related disorders. However, management of symptoms and complications associated with these conditions may involve moisturizers, topical medications, and other dermatological interventions to help alleviate skin-related issues.

Is AQP3 expressed only in humans? 08/15/2019

No, AQP3 is not exclusive to humans. It is found in various animal species, including mammals, birds, and reptiles. Its presence in different organisms suggests its evolutionary significance in water balance regulation and other biological processes.

How is the AQP3 protein regulated in the body? 11/18/2017

The expression and activity of AQP3 can be regulated by various factors. Hormones, such as glucocorticoids and thyroid hormones, have been shown to influence AQP3 expression in certain tissues. Additionally, signaling pathways like the cAMP-protein kinase A pathway and the MAPK pathway have been implicated in the regulation of AQP3 activity.

How is the AQP3 protein regulated in the body? 11/18/2017

The expression and activity of AQP3 can be regulated by various factors. Hormones, such as glucocorticoids and thyroid hormones, have been shown to influence AQP3 expression in certain tissues. Additionally, signaling pathways like the cAMP-protein kinase A pathway and the MAPK pathway have been implicated in the regulation of AQP3 activity.

Are there any known inhibitors or activators of AQP3? 06/06/2017

Several compounds have been identified as potential AQP3 inhibitors or activators. For example, some natural substances like flavonoids and polyphenols have been found to inhibit AQP3 function. Conversely, certain synthetic compounds, such as AQP3 activators 4-Chlorobenzoylisothiocyanate and phloretin, have been shown to enhance AQP3 activity.

Are there any known inhibitors or activators of AQP3? 06/06/2017

Several compounds have been identified as potential AQP3 inhibitors or activators. For example, some natural substances like flavonoids and polyphenols have been found to inhibit AQP3 function. Conversely, certain synthetic compounds, such as AQP3 activators 4-Chlorobenzoylisothiocyanate and phloretin, have been shown to enhance AQP3 activity.

Are there any other proteins that interact with AQP3? 09/28/2016

Yes, AQP3 can interact with other proteins within the cell. For instance, it has been shown to interact with ezrin, a cytoskeletal protein, in the kidney. This interaction may play a role in the intracellular trafficking of AQP3 and its localization to specific membrane domains.

Are there any other proteins that interact with AQP3? 09/28/2016

Yes, AQP3 can interact with other proteins within the cell. For instance, it has been shown to interact with ezrin, a cytoskeletal protein, in the kidney. This interaction may play a role in the intracellular trafficking of AQP3 and its localization to specific membrane domains.

Can AQP3 be targeted for drug delivery purposes? 07/13/2016

AQP3 has been explored for drug delivery applications. Due to its water transport function, it can potentially be utilized to improve the delivery of hydrophilic drugs. By understanding the mechanisms of AQP3-mediated water transport, researchers are exploring ways to engineer drug carriers that can exploit these channels for efficient drug delivery.

Can AQP3 be targeted for drug delivery purposes? 07/13/2016

AQP3 has been explored for drug delivery applications. Due to its water transport function, it can potentially be utilized to improve the delivery of hydrophilic drugs. By understanding the mechanisms of AQP3-mediated water transport, researchers are exploring ways to engineer drug carriers that can exploit these channels for efficient drug delivery.

Customer Reviews (8)

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Reviews
02/02/2022

    This level of support saves researchers time and resources, enabling them to focus on the scientific aspects of their work and accelerate the overall progress of their studies.

    08/27/2021

      its high quality and purity ensure accurate and reliable results.

      02/02/2019

        If researchers require specific variants or modifications of AR protein, the manufacturer can work with them to provide customized products tailored to their needs.

        06/30/2018

          Manufacturers may offer the option for custom protein production.

          03/06/2018

            The AQP3 protein exhibits several valuable attributes that make it an excellent choice for my trials.

            04/17/2017

              With the manufacturer's unwavering dedication to delivering quality products and unparalleled technical support, I am confident in their ability to help me overcome any challenges and propel my research forward.

              04/17/2017

                the stability of the AQP3 protein enables me to conduct experiments over an extended period, reducing the need for frequent restocking and promoting experimental consistency.

                01/10/2016

                  Their expertise can help troubleshoot problems, suggest alternative approaches, or provide recommendations for optimizing experimental protocols.

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