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AQP6

  • Official Full Name

    aquaporin 6, kidney specific

  • Overview

    The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This protein is specific for the kidney. This gene and related family members AQP0, AQP2, and AQP5 reside in a cluster on chromosome 12q13.
  • Synonyms

    AQP6; aquaporin 6, kidney specific; AQP2L; aquaporin-6; hKID; AQP-6; kidney-specific aquaporin; aquaporin-6, kidney specific; aquaporin 2-like, kidney specific; KID;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Milnesium tardigradum (Water bear) (Tardigrade)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • Tag
  • Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AQP6-8766HCL Recombinant Human AQP6 293 Cell Lysate HEK293 N/A
Human AQP6-301468H Recombinant Human AQP6 protein, GST-tagged E.coli GST Met221-Val282
Human AQP6-2680H Recombinant Human AQP6 protein, His-tagged E.coli His 221 - 282 aa
Mouse AQP6-1825M Recombinant Mouse AQP6 Protein Mammalian Cell His
Mouse AQP6-651M Recombinant Mouse AQP6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse AQP6-651M-B Recombinant Mouse AQP6 Protein Pre-coupled Magnetic Beads HEK293
Rat AQP6-740R Recombinant Rat AQP6 Protein Mammalian Cell His
Rat AQP6-396R Recombinant Rat AQP6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AQP6-396R-B Recombinant Rat AQP6 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL17928HF Recombinant Full Length Human Aquaporin-6(Aqp6) Protein, His-Tagged E.coli expression system His Full Length (1-282)
Milnesium tardigradum (Water bear) (Tardigrade) RFL9235MF Recombinant Full Length Milnesium Tardigradum Aquaporin-6(Aqp6) Protein, Tag-Free E.coli expression system Tag-Free Full Length (1-285)
Mus musculus (Mouse) RFL8222MF Recombinant Full Length Mouse Aquaporin-6(Aqp6) Protein, His-Tagged E.coli expression system His Full Length (1-293)
Rattus norvegicus (Rat) RFL27637RF Recombinant Full Length Rat Aquaporin-6(Aqp6) Protein, His-Tagged E.coli expression system His Full Length (1-276)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AQP6 Related Articles

AQP6 involved in several pathways and played different roles in them. We selected most pathways AQP6 participated on our site, such as Aquaporin-mediated transport, Passive transport by Aquaporins, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with AQP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Aquaporin-mediated transportADCY8;AQP10B;MIP;MIPB;ADCY7;AQP6;AQP10A;AQP1A.2;AQP10
Passive transport by AquaporinsAQP1A.2;AQP10B;AQP10A;AQP8A.1;MIP;AQP1A.1;MIPB;AQP3A;AQP3B
Transmembrane transport of small moleculesTRPC4APA;SLC10A6;FLVCR1;SLC8A2A;CLCN1A;SLC2A7;SLC17A3;CLCA1;TRPM1

AQP6 has several biochemical functions, for example, anion channel activity, glycerol channel activity, nitrate transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AQP6 itself. We selected most functions AQP6 had, and list some proteins which have the same functions with AQP6. You can find most of the proteins on our site.

Function Related Protein
anion channel activityCCT8L2;AQP6
glycerol channel activityAQP1A.2;AQP1A.1;AQP10B;AQP8A.2;AQP7;MIPB;AQP1;AQP6;AQP10
nitrate transmembrane transporter activity
water channel activityAQP8A.1;AQP10B;AQP10A;AQP9;AQP3A;AQP3B;AQP8A.2;AQP1;AQP4

AQP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AQP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of AQP6.

Ishiyama, G; Lopez, IA; et al. Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma. CELL AND TISSUE RESEARCH 340:407-419(2010).
Matsuki-Fukushima, M; Hashimoto, S; et al. Presence and localization of aquaporin-6 in rat parotid acinar cells. CELL AND TISSUE RESEARCH 332:73-80(2008).
  • Q&As
  • Reviews

Q&As (24)

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Are there any pharmacological agents or drugs that specifically target AQP6? 04/29/2023

Currently, there are no specific drugs or pharmacological agents available that specifically target AQP6. However, research is ongoing to develop compounds that can modulate the activity of aquaporin channels, including AQP6, for potential therapeutic purposes. These efforts aim to find compounds that can either enhance or inhibit AQP6 function, depending on the desired clinical outcome.

Are there any pharmacological agents or drugs that specifically target AQP6? 04/29/2023

Currently, there are no specific drugs or pharmacological agents available that specifically target AQP6. However, research is ongoing to develop compounds that can modulate the activity of aquaporin channels, including AQP6, for potential therapeutic purposes. These efforts aim to find compounds that can either enhance or inhibit AQP6 function, depending on the desired clinical outcome.

Can genetic mutations in AQP6 lead to any disorders or diseases? 01/27/2023

Genetic mutations in AQP6 have been associated with a rare disorder called recessive distal renal tubular acidosis (dRTA). dRTA is characterized by impaired acid secretion in the kidneys, leading to metabolic acidosis. However, more research is needed to fully understand the relationship between AQP6 mutations and the development of dRTA.

How is the expression of AQP6 regulated in the kidney? 06/29/2022

The expression of AQP6 in the kidney is regulated by several factors. One important regulator is the hormone vasopressin, also known as antidiuretic hormone (ADH). Vasopressin acts on the renal collecting ducts and upregulates the transcription and expression of AQP2, which is closely related to AQP6. AQP2 and AQP6 share some regulatory mechanisms, and studies have shown that vasopressin can also influence AQP6 expression. Additionally, other factors such as pH levels, electrolyte balance, and hormonal signaling pathways may also impact the regulation of AQP6 in the kidney.

How is the expression of AQP6 regulated in the kidney? 06/29/2022

The expression of AQP6 in the kidney is regulated by several factors. One important regulator is the hormone vasopressin, also known as antidiuretic hormone (ADH). Vasopressin acts on the renal collecting ducts and upregulates the transcription and expression of AQP2, which is closely related to AQP6. AQP2 and AQP6 share some regulatory mechanisms, and studies have shown that vasopressin can also influence AQP6 expression. Additionally, other factors such as pH levels, electrolyte balance, and hormonal signaling pathways may also impact the regulation of AQP6 in the kidney.

Can AQP6 be targeted for therapeutic interventions? 05/13/2022

AQP6's unique properties and role in kidney function make it an intriguing target for therapeutic interventions. However, since AQP6 has complex interactions and its precise roles are still being elucidated, developing specific drugs targeting AQP6 remains a challenge.

Are there any diseases or conditions associated with dysfunction of AQP6? 02/23/2022

Although relatively less well-studied than other aquaporins, dysfunction or mutations in AQP6 have been associated with recessive distal renal tubular acidosis (dRTA). In individuals with dRTA, there is impaired acid secretion in the distal tubules of the kidney, leading to an inability to effectively excrete acid and maintain proper acid-base balance. dRTA is characterized by metabolic acidosis and can result in symptoms such as electrolyte imbalances, growth abnormalities, and kidney stone formation.

Are there any diseases or conditions associated with dysfunction of AQP6? 02/23/2022

Although relatively less well-studied than other aquaporins, dysfunction or mutations in AQP6 have been associated with recessive distal renal tubular acidosis (dRTA). In individuals with dRTA, there is impaired acid secretion in the distal tubules of the kidney, leading to an inability to effectively excrete acid and maintain proper acid-base balance. dRTA is characterized by metabolic acidosis and can result in symptoms such as electrolyte imbalances, growth abnormalities, and kidney stone formation.

How does AQP6 contribute to water and solute transport in the kidney? 11/09/2021

AQP6 is predominantly expressed in the intercalated cells of the renal collecting ducts in the kidney. It plays a role in regulating water and solute transport in this part of the nephron. AQP6 acts as a water channel and allows for the movement of water across the cell membrane, facilitating the reabsorption or excretion of water depending on the needs of the body.

How does AQP6 contribute to water and solute transport in the kidney? 11/09/2021

AQP6 is predominantly expressed in the intercalated cells of the renal collecting ducts in the kidney. It plays a role in regulating water and solute transport in this part of the nephron. AQP6 acts as a water channel and allows for the movement of water across the cell membrane, facilitating the reabsorption or excretion of water depending on the needs of the body.

Are there any therapeutic approaches targeting AQP6 indirectly, such as through downstream signaling pathways? 10/15/2021

While there are currently no direct therapeutic approaches targeting AQP6, some research has focused on modulating downstream signaling pathways that could indirectly affect AQP6 function. For example, targeting signaling molecules like vasopressin or angiotensin II, which regulate AQP6 expression, could potentially alter AQP6 activity in a therapeutic context. However, further research is needed to explore the feasibility and potential effectiveness of these indirect therapeutic approaches.

Are there any therapeutic approaches targeting AQP6 indirectly, such as through downstream signaling pathways? 10/15/2021

While there are currently no direct therapeutic approaches targeting AQP6, some research has focused on modulating downstream signaling pathways that could indirectly affect AQP6 function. For example, targeting signaling molecules like vasopressin or angiotensin II, which regulate AQP6 expression, could potentially alter AQP6 activity in a therapeutic context. However, further research is needed to explore the feasibility and potential effectiveness of these indirect therapeutic approaches.

Is there any potential for therapeutic targeting of AQP6 in kidney disorders? 08/09/2021

The understanding of AQP6's role in kidney function and its potential involvement in renal disorders is still evolving. While there are currently no approved therapies directly targeting AQP6, advancements in research may uncover potential therapeutic strategies. For example, modulating AQP6 expression or function could potentially be explored as a therapeutic approach for addressing disorders like dRTA. However, more research is needed to fully understand the underlying mechanisms and potential treatment options targeting AQP6 in kidney disorders.

Is there any potential for therapeutic targeting of AQP6 in kidney disorders? 08/09/2021

The understanding of AQP6's role in kidney function and its potential involvement in renal disorders is still evolving. While there are currently no approved therapies directly targeting AQP6, advancements in research may uncover potential therapeutic strategies. For example, modulating AQP6 expression or function could potentially be explored as a therapeutic approach for addressing disorders like dRTA. However, more research is needed to fully understand the underlying mechanisms and potential treatment options targeting AQP6 in kidney disorders.

Are there any drugs or therapies that target AQP6? 06/11/2021

Currently, there are no specific drugs or therapies targeting AQP6. However, understanding the regulation and function of AQP6 may provide valuable insights for the development of future treatments for water balance disorders or renal diseases.

Are there any known mutations or variations in the AQP6 gene associated with diseases? 05/31/2021

To date, no disease-specific mutations in the AQP6 gene have been identified. However, variations in AQP6 expression and function have been implicated in renal disorders such as nephrogenic diabetes insipidus, which affects the ability to concentrate urine.

What are the consequences of AQP6 dysfunction? 03/21/2021

Dysfunction or dysregulation of AQP6 can lead to impaired water reabsorption in the kidney, potentially contributing to disorders such as nephrogenic diabetes insipidus. Altered AQP6 expression has also been associated with urolithiasis, or the formation of kidney stones.

How is the structure of AQP6 protein organized? 08/23/2020

AQP6 protein consists of six transmembrane helices that span the cell membrane, with N- and C-termini located on the cytoplasmic side. These helices create a water-conducting pore through which water molecules can pass.

How is AQP6 affected by different environmental factors? 09/12/2019

AQP6 activity can be influenced by various environmental factors. For example, studies have shown that changes in pH levels can affect AQP6 gating, leading to alterations in water transport. Additionally, certain ions, such as calcium and potassium, have been found to modulate AQP6 function. Exposure to different chemicals or drugs may also affect AQP6 activity, although more research is needed to understand the specific mechanisms of these interactions.

How is AQP6 affected by different environmental factors? 09/12/2019

AQP6 activity can be influenced by various environmental factors. For example, studies have shown that changes in pH levels can affect AQP6 gating, leading to alterations in water transport. Additionally, certain ions, such as calcium and potassium, have been found to modulate AQP6 function. Exposure to different chemicals or drugs may also affect AQP6 activity, although more research is needed to understand the specific mechanisms of these interactions.

Can AQP6 have any potential implications in conditions other than kidney disorders? 07/27/2018

Although AQP6 is primarily studied in the context of renal function, its expression has also been detected in other tissues, including the brain and reproductive organs. Further research is needed to fully understand the role of AQP6 in these tissues and its potential implications in related conditions or diseases.

Are there any known interactions with other proteins or molecules affecting AQP6 activity? 07/09/2018

AQP6 may interact with other proteins or molecules within the cell membrane, influencing its activity. For example, certain phospholipids have been found to modulate AQP6 function. Further research is needed to fully understand these interactions and their impact on AQP6 activity.

Are there any ongoing studies or research focused on AQP6? 04/16/2016

Yes, ongoing research is focused on further understanding the role of AQP6 in kidney function, its regulation, and potential implications in related disorders. Additionally, efforts are being made to uncover its presence and functions outside the kidney in different organs and tissues.

Are there any ongoing studies or research focused on AQP6? 04/16/2016

Yes, ongoing research is focused on further understanding the role of AQP6 in kidney function, its regulation, and potential implications in related disorders. Additionally, efforts are being made to uncover its presence and functions outside the kidney in different organs and tissues.

Customer Reviews (8)

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Reviews
01/17/2023

    Its unique characteristics contribute to obtaining clear and detailed structural information, enabling researchers to unravel the intricate complexities of protein interactions and conformational changes.

    04/23/2022

      This protein exhibits outstanding performance in ELISA, providing accurate and reliable results in detecting and quantifying specific antigens.

      10/28/2021

        Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various disciplines.

        10/01/2021

          Researchers can confidently rely on its capabilities to generate precise and significant results, enhancing the understanding of protein function and dynamics.

          04/19/2020

            By relying on the AQP6 protein and the manufacturer's exceptional technical support, researchers can confidently pursue their experimental goals while knowing they have access to reliable resources and expert guidance.

            10/03/2019

              Its versatility in various biological applications, along with its compatibility with different techniques, strongly recommend it as a preferred reagent for researchers in the field.

              03/24/2019

                Its stability and compatibility with electron microscopy techniques make it an excellent choice for studying protein structures at high resolution.

                08/15/2018

                  Its high sensitivity ensures the detection of even low abundance targets, making it a valuable tool in immunoassays.

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