araf
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  • Official Full Name
  • v-raf murine sarcoma 3611 viral oncogene homolog
  • Background
  • A-Raf, B-Raf and c-Raf (Raf-1) are the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway. Activation of c-Raf is the best understood and involves phosphorylation at multiple activating sites including Ser338, Tyr341, Thr491,
  • Synonyms
  • ARAF; v-raf murine sarcoma 3611 viral oncogene homolog; ARAF1, v raf murine sarcoma 3611 viral oncogene homolog 1; serine/threonine-protein kinase A-Raf; Oncogene ARAF1; proto-oncogene Pks; proto-oncogene A-Raf-1; Ras-binding protein DA-Raf; v-raf murine
Cat.#:ARAF-186HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ARAF protein, His-tagged
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Cat.#:ARAF-187HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ARAF protein, GST-tagged
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Cat.#:ARAF-32HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ARAF protein, GST-tagged
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Cat.#:ARAF-398HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ARAF protein, MYC/DDK-tagged
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Cat.#:ARAF-504HTag:His/GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ARAF protein, His/GST-tagged
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Cat.#:ARAF-738HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ARAF protein, GST-tagged
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Cat.#:ARAF-1831MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ARAF Protein
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Cat.#:ARAF-11758ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ARAF
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Cat.#:ARAF-105HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ARAF cell lysate
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Involved Pathway

ARAF involved in several pathways and played different roles in them. We selected most pathways ARAF participated on our site, such as ErbB signaling pathway, FoxO signaling pathway, Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
AKT2L; MTOR; RAF1A; SHC4; RAF1; EREG; PAK7; MAP2K4A; PLCG1; MAP2K2A
FoxO signaling pathway
FOXO3B; PCK1; PIK3R3A; EGFRA; SMAD4; G6PC3; TGFBR1B; SETD7; CCNG2; PLK2B
Vascular smooth muscle contraction
BRAF; CALD1B; GNA12; PLCB2; CALM4; CALD1; CALM1; MAP2K2B; RHOAA; KCNMB2
Natural killer cell mediated cytotoxicity
IFNA14; RAET1E; FCGR4; IFNA4; SOS1; NCR1; RAF1; KIR3DL1; HLA-G; IFNA12
Long-term potentiation
RPS6KA6; MAP2K1; PRKACB; CAMK2D; PPP3CC; PPP3R1; PLCB1; NRAS; GRIN2B; PPP1CC
Serotonergic synapse
PLCB1; MAOB; KCND2; BRAF; PRKCA; PLA2G4D; GNAS; CYP2C55; GNGT2; MAOA
Long-term depression
GNAS; PPP2CB; RAF1; GRIA1; RYR1; CRHR1; PPP2R1A; NOS1; GUCY1A3; PLCB3
Regulation of actin cytoskeleton
PAK2; RASSF7; PIP4K2B; GNA13A; RHOAA; FGF9; GNG12A; LIMK1; MAP2K1; MAP2K2A
Insulin signaling pathway
MTOR; PDE3B; PPP1R3D; EIF4E1B; FLOT1A; HRASB; ELK1; PRKAR2AB; GRB2; CALML3
Progesterone-mediated oocyte maturation
CPEB4; INSB; IGF1RA; ADCY1B; PIK3CG; RAF1; MAD2L2; CPEB1A; MAPK12A; IGF1
Alcoholism
CREB3L2; HIST1H3C; MAOA; HIST1H2BL; H2AFB1; HIST1H2AG; GM14479; HIST1H2BP; HIST1H2AI; CALM2
Hepatitis C
TP53; PPP2R2B; TBK1; CLDN7; ARAF; HRAS; IFNB1; TRAF2; Ifna11; EIF3E
Pathways in cancer
HSP90AA1; ITGA2B; Ar; ROCK2; HHIP; MSH3; FZD9; RAC1; SLC2A1; MDM2
Proteoglycans in cancer
WNT1; CAMK2A; PRKCA; PLCG1; ERBB3; SRC; WNT5A; EZR; TWIST2; WNT16
Colorectal cancer
PIK3R2; BCL2; MSH2; MAP2K1; SMAD4; PIK3CG; MSH3; RAC2; MAPK10; APC2
Renal cell carcinoma
PIK3CG; TCEB2; PDGFB; ARNT; RAP1B; MAPK3; ARNT2; PAK1; TGFB2; RAP1A
Pancreatic cancer
STAT3; IKBKG; PIK3CG; SMAD3; SMAD4; TGFB1; MAPK8; IKBKB; MAPK3; PIK3CB
Endometrial cancer
TP53; MLH1; PIK3CA; ARAF; GSK3B; PIK3R5; PDPK1; APC; MAPK1; SOS1
Glioma
SHC4; SHC3; MAPK3; RB1; MAPK1; CALM2; IGF1; PIK3R1; PLCG2; Pdgfa&Pdgfb
Prostate cancer
PDGFRB; PIK3CG; PIK3CB; PDGFA; SPINK1; GRB2; SOS1; GSTP1; PIK3CA; TGFA
Melanoma
MAP2K1; FGF10; PIK3CD; CDH1; FGF12; PDGFA; BRAF; AKT2; FGF5; FGF9
Bladder cancer
MAPK3; SRC; HRAS; TYMP; DAPK3; EGF; MMP1; E2F2; CDKN2A; RASSF1
Chronic myeloid leukemia
AKT1; RB1; STAT5B; TRP53; PIK3R5; NRAS; IKBKB; SHC1; ABL1; CTBP2
Acute myeloid leukemia
BAD; KIT; AKT1; STAT3; RARA; CEBPA; PPARD; KRAS; NRAS; STAT5A
Non-small cell lung cancer
AKT1; STK4; PLCG1; RXRA; RASSF5; RB1; PRKCB; CASP9; HRAS; TP53

Protein Function

ARAF has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARAF itself. We selected most functions ARAF had, and list some proteins which have the same functions with ARAF. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CLCN6; ACLY; PSMC4; MARK2; EPHA3; DHX58; CCT4; DICER1; HNRNPU; ATP1A2A
Function metal ion binding
Related Protein PRKCDA; ZBTB37; GRIN2A; ITGB1BP3; CPEB1B; ING5A; TRIM35-23; PDP1; PPM1AA; MUL1A
Function protein binding
Related Protein PACSIN2; SLC6A20; TBC1D22B; LPL; MAP3K7; ARFIP2; MIS18BP1; VEGFAB; SNRPN; RAB17
Function protein kinase activity
Related Protein RPS6KAL; CDK9; MAP2K4B; PRKCA; BMPR1AB; TNIK; GSK3AA; RAF1A; TAOK1; TRIM24
Function protein serine/threonine kinase activity
Related Protein CSNK1G1; CDKL5; MAPK6; RPS6KA3; RIPK3; GM4922; LRRK1; PRKCZ; STK36; CAMK2A
Function receptor signaling protein activity
Related Protein IFITM1; DOK5; PLCG1; RGS12; CD19; FCAR; cgr2b; NGF; ARAF; RAF1B

Interacting Protein

ARAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARAF here. Most of them are supplied by our site. Hope this information will be useful for your research of ARAF.
MAP2K2; YWHAZ; HSP90AB1; YWHAG

ARAF Related Articles

Yu, L; Yu, CJ; et al. Structural analysis of galactoarabinan from duckweed. CARBOHYDRATE POLYMERS 117:807-812(2015).
Sumiyoshi, M; Nakamura, A; et al. Increase in Cellulose Accumulation and Improvement of Saccharification by Overexpression of Arabinofuranosidase in Rice. PLOS ONE 8:-(2013).