araf
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  • Official Full Name
  • v-raf murine sarcoma 3611 viral oncogene homolog
  • Background
  • A-Raf, B-Raf and c-Raf (Raf-1) are the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway. Activation of c-Raf is the best understood and involves phosphorylation at multiple activating sites including Ser338, Tyr341, Thr491,
  • Synonyms
  • ARAF; v-raf murine sarcoma 3611 viral oncogene homolog; ARAF1, v raf murine sarcoma 3611 viral oncogene homolog 1; serine/threonine-protein kinase A-Raf; Oncogene ARAF1; proto-oncogene Pks; proto-oncogene A-Raf-1; Ras-binding protein DA-Raf; v-raf murine
Cat.#:ARAF-186HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ARAF protein, His-tagged
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Cat.#:ARAF-187HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ARAF protein, GST-tagged
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Cat.#:ARAF-32HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ARAF protein, GST-tagged
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Cat.#:ARAF-398HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ARAF protein, MYC/DDK-tagged
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Cat.#:ARAF-504HTag:His/GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ARAF protein, His/GST-tagged
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Cat.#:ARAF-738HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ARAF protein, GST-tagged
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Cat.#:ARAF-1831MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ARAF Protein
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Cat.#:ARAF-11758ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ARAF
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Cat.#:ARAF-105HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ARAF cell lysate
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Involved Pathway

ARAF involved in several pathways and played different roles in them. We selected most pathways ARAF participated on our site, such as ErbB signaling pathway, FoxO signaling pathway, Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
BAD; STAT5B; ERBB4; CDKN1BA; CAMK2D1; RPS6KB1B; CAMK2D2; HRASB; MAP2K7; SHC2
FoxO signaling pathway
IGF1; MAPK11; GRM1; SOD2; PIK3CG; PRKAG3B; ATM; FOXG1A; GADD45AA; SETD7
Vascular smooth muscle contraction
MAP2K2B; GNA12A; GNA11; PPP1R14AB; CALML5; PLCB1; MYLK3; CALM2B; PLCB2; PRKCD
Natural killer cell mediated cytotoxicity
KLRC2; VAV1; H60a; CD48; RAC1; SH2D1A; PIK3CB; ZAP70; VAV2; ULBP3
Long-term potentiation
PLCB1; PPP3R1; RAF1; ARAF; PPP3CC; PRKCA; PRKACB; GRIN2C; CAMK4; MAP2K1
Serotonergic synapse
CYP2C55; PLCB1; GNAI3; ALOX5; KCND2; HTR3B; PRKCA; ITPR3; NRAS; KRAS
Long-term depression
PLA2G4D; PRKCG; LYN; NRAS; ITPR3; GNAI1; MAP2K2; ARAF; PPP2CA; GNAZ
Regulation of actin cytoskeleton
PIP4K2A; WAS; PIP4K2C; RAF1B; IQGAP2; PIK3R3A; FGF8A; RAC2; CYFIP2; ITGA5
Insulin signaling pathway
PIK3R3; PCK1; FLOT1B; PRKAR1B; HK2; LIPE; SOCS3; PPARGC1A; PHKG2; PRKAG2
Progesterone-mediated oocyte maturation
IGF1RB; AKT2; MAD1L1; GNAI2B; ANAPC5; SPDYA; CCNA1; MAPK1; CDK1; CPEB1A
Alcoholism
HIST1H4A; GM14476; CREB3L4; HIST1H2AH; HIST2H2BE; HIST1H2BC; DDC; CRH; HIST1H4D; NTRK2
Hepatitis C
CLDN20; TYK2; OAS2; LDLR; GRB2; CLDN9; SCARB1; NFKBIA; CLDN15; IRF3
Pathways in cancer
HDAC2; Flt3l; Fasl; FZD3; AXIN2; BCL2; LAMA1; FGF18; FLT3; EGLN3
Proteoglycans in cancer
BRAF; ARHGEF1; ELK1; DDX5; DROSHA; SLC9A1; Ctsl; CAMK2D; PIK3CA; TWIST1
Colorectal cancer
TGFBR1; TGFB2; MLH1; TRP53; ARAF; APPL1; TGFB3; AXIN2; CCND1; MSH3
Renal cell carcinoma
ETS1; EP300; PIK3CD; PTPN11; SLC2A1; PAK1; FH; TGFB1; HRAS; GRB2
Pancreatic cancer
ARHGEF6; RAC2; SMAD2; CDC42; IKBKG; STAT1; RALGDS; PIK3CA; BRCA2; RALBP1
Endometrial cancer
TCF7L2; MAPK1; MAPK3; TP53; PIK3CA; SOS1; AXIN2; GSK3B; PIK3R5; BRAF
Glioma
PLCG2; MAP2K2; PTEN; MTOR; PIK3CD; CAMK2D; SHC3; SHC4; IGF1; PIK3R5
Prostate cancer
PIK3R3; HRAS; SRD5A2; ARAF; SMARCA4; PIK3CD; CPN1; PIK3CA; TCF7; GRB2
Melanoma
MET; PIK3CA; FGF13; Pdgfa&Pdgfb; PDGFRA; FGF22; FGF10; FGF12; FGF2; IGF1R
Bladder cancer
MAP2K2; MAPK1; MAP2K1; DAPK2; CDK4; RPS6KA5; ARAF; E2F1; E2F3; VEGFA
Chronic myeloid leukemia
CTBP1; TGFB1; NRAS; MAPK3; ABL1; SHC2; PTPN11; TGFB3; TRP53; RELA
Acute myeloid leukemia
RAF1; MAPK1; RARA; NFKB1; MYC; GRB2; PIK3CA; NRAS; ZBTB16; IKBKB
Non-small cell lung cancer
SOS1; PIK3R1; RB1; BRAF; CCND1; PIK3CD; GRB2; MAP2K1; HRAS; PLCG1

Protein Function

ARAF has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARAF itself. We selected most functions ARAF had, and list some proteins which have the same functions with ARAF. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NARS; DMPK; NADKD1; ATP2A2; GUCY2F; ACSM5; AACS; NSFA; GRK4; ROCK2B
Function metal ion binding
Related Protein ZFP641; ZFP787; ASAP1; Alb; DMRT2; ARSB; CISD3; ZNF383; CYP27C1; CYP2K17
Function protein binding
Related Protein HAND2; SRSF2; BRPF3; C10orf46; RAC3; WRAP53; GALNT3; FBXO17; SSNA1; CALM1
Function protein kinase activity
Related Protein RAF1B; AURKA; RPS6KA3B; CAMK1GB; MAP3K5; EIF2AK2; HIPK3A; NLK1; CDK7; SRPK1B
Function protein serine/threonine kinase activity
Related Protein CIT; DAPK2; RIPK4; PRKG1A; CAMK2G1; PAK2B; MYLK4; MKNK2; MAP2K2; PAK7
Function receptor signaling protein activity
Related Protein GNAZ; TYROBP; PLCE1; Siglece; TRAIP; ADCYAP1; BAG4; TIAM2; NGF; RGS14A

Interacting Protein

ARAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARAF here. Most of them are supplied by our site. Hope this information will be useful for your research of ARAF.
MAP2K2; YWHAZ; HSP90AB1; YWHAG

ARAF Related Articles

Yu, L; Yu, CJ; et al. Structural analysis of galactoarabinan from duckweed. CARBOHYDRATE POLYMERS 117:807-812(2015).
Sumiyoshi, M; Nakamura, A; et al. Increase in Cellulose Accumulation and Improvement of Saccharification by Overexpression of Arabinofuranosidase in Rice. PLOS ONE 8:-(2013).