ARAP2
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Official Full Name
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
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Overview
The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. -
Synonyms
ARAP2; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2; centaurin, delta 1 , CENTD1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2; PARX; cnt-d1; centaurin-delta-1; centaurin, delta 1; Arf and Rho GAP adapter protein;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ARAP2-9791H | Recombinant Human ARAP2, His-tagged | E.coli | His | C-term-349a.a. |
- Involved Pathway
- Protein Function
- Interacting Protein
- ARAP2 Related Articles
ARAP2 involved in several pathways and played different roles in them. We selected most pathways ARAP2 participated on our site, such as Arf6 signaling events, Endocytosis, Rho GTPase cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arf6 signaling events | GULP1;EGFR;EGF;EPHA2;AGTR1;ADRB2;ADAP1;ARAP2;KIF13B |
| Endocytosis | ARF3A;ASAP2;RHOA;IGF1RA;SMURF1;CHMP1B;ARFGEF2;ARF6A;ASAP3 |
| Rho GTPase cycle | ARAP2;ARHGAP29B;DEPDC1B;FAM13A;RHOU;FAM13B1;ARHGAP36;ARHGAP9;ARHGEF18 |
| Signal Transduction | RLBP1B;DHRS4;RDH14A;ANXA1B;PMCH;ADH8A;BCO2;NRP2B;OXTRL |
| Signaling by Rho GTPases | FAM13A;NOXO1A;MKL1B;RHOUA;ARHGAP15;ARHGAP1;RHPN2;DEPDC7;PRC1 |
ARAP2 has several biochemical functions, for example, GTPase activator activity, metal ion binding, phosphatidylinositol-3,4,5-trisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARAP2 itself. We selected most functions ARAP2 had, and list some proteins which have the same functions with ARAP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | RGS21;ASAP2A;DOCK2;ARHGAP28;TBC1D2;EVI5;RGS18;ELMOD2;ECT2 |
| metal ion binding | ZFP551;CALUA;PLD6;COL1A1;ZNF302;BHLHE22;ZNF606;ZNF483;ZNF367 |
| phosphatidylinositol-3,4,5-trisphosphate binding | COMMD1;MYO1G;CYTH3;OGT;RAG2;ARAP1;ASAP1;FERMT2;MAPKAP1 |
ARAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARAP2.
Dlg4; q81nr7_bacan; malK
- Q&As
- Reviews
Q&As (8)
Ask a questionThe activity of the ARAP2 protein can be regulated through various mechanisms. One important regulatory process is protein phosphorylation. Phosphorylation of specific residues within ARAP2 can modulate its activity and interactions with other proteins. Additionally, ARAP2 can be regulated through protein-protein interactions, where binding to certain proteins can influence its localization, binding partners, or activity.
Yes, as mentioned earlier, specific mutations or variations in the ARAP2 gene have been linked to neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). Dysregulation of ARAP2 in these disorders suggests its involvement in neuronal development, synaptic function, and potentially other processes relevant to brain function and behavior.
Currently, there do not appear to be any ongoing clinical trials specifically focused on the ARAP2 protein. However, there is ongoing research exploring ARAP2's involvement in neurodevelopmental disorders, cancer biology, and other cellular processes. These studies aim to better understand its function and potential therapeutic implications.
ARAP2 has been implicated in several cellular processes that are relevant to cancer progression. It is involved in cell migration and invasion, both of which play crucial roles in tumor metastasis. Additionally, ARAP2 has been observed to affect cell proliferation and survival pathways, suggesting its potential involvement in cancer cell growth. However, more research is needed to fully understand the specific role of ARAP2 in cancer biology.
Currently, there are no known specific inhibitors or activators targeting the ARAP2 protein. However, this does not rule out the possibility of future discoveries or development of compounds that modulate its activity. Further research is needed to identify and characterize ARAP2-specific modulators.
Yes, the ARAP2 protein is involved in multiple signaling pathways. It interacts with different molecules and proteins, including small GTPases, receptor tyrosine kinases, and cell adhesion molecules, to regulate downstream signaling cascades. ARAP2 has been implicated in pathways such as the Rho family GTPase signaling pathway, phosphoinositide signaling pathway, and integrin-mediated signaling.
Some genetic variations or mutations in the ARAP2 gene have been associated with certain conditions. For example, specific mutations in the ARAP2 gene have been linked to neurodevelopmental disorders, including autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). However, more research is needed to fully understand the role of ARAP2 gene variations in these disorders.
Targeting the ARAP2 protein itself is yet to be explored for therapeutic interventions. However, as ARAP2 is involved in various signaling pathways and cellular processes, it is possible that targeting downstream effectors or pathways connected to ARAP2 could have therapeutic potential. It would require further investigation to identify potential druggable targets within these pathways.
Customer Reviews (8)
Write a reviewthe ARAP2 protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.
This protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.
The ARAP2 protein is of exceptional quality, making it an ideal choice to meet my experimental needs.
Their team of experts is readily available to address any issues that may arise, providing solutions to problems and guiding me through the experimental process.
The ARAP2 protein is an outstanding product that possesses exceptional quality, making it an ideal choice for my experimental needs.
What sets ARAP2 apart is the manufacturer's unparalleled technical support.
The versatility of the ARAP2 protein makes it a valuable asset in my research.
The ARAP2 protein is highly recommended for researchers conducting protein studies, especially in Western blotting (WB) experiments.
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