ARFGEF1 Protein, ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)


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Official Full Name ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
Background ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition.
Synonyms ARFGEF1; ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited); brefeldin A-inhibited guanine nucleotide-exchange protein 1; ARFGEP1; BIG1; DKFZP434L057; p200; ADPribosylation factor guanine nucleotide exchange factor 1(brefeldin A inhibited); Brefeldin A inhibited GEP 1; Brefeldin A inhibited guanine nucleotide exchange protein 1; p200 ARF GEP1; p200 ARF guanine nucleotide exchange factor; OTTHUMP00000227052; OTTHUMP00000227095
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ARFGEF1-752H Recombinant Human ARFGEF1 protein, GST-tagged Wheat Germ GST
    Mouse ARFGEF1-1846M Recombinant Mouse ARFGEF1 Protein Mammalian Cell His
    Rhesus Macaque ARFGEF1-383R Recombinant Rhesus monkey ARFGEF1 Protein, His-tagged Mammalian Cell His

    ARFGEF1 involved in several pathways and played different roles in them. We selected most pathways ARFGEF1 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARFGEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis HRASA; RAB11FIP3; SPG21; PARD6A; VPS35; PSD3; CSF1RA; FOLR3; HSPA1B; VPS37D

    ARFGEF1 has several biochemical functions, for example, guanyl-nucleotide exchange factor activity, myosin binding, protein kinase A regulatory subunit binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARFGEF1 itself. We selected most functions ARFGEF1 had, and list some proteins which have the same functions with ARFGEF1. You can find most of the proteins on our site.

    Function Related Protein
    guanyl-nucleotide exchange factor activity DOCK5; ARFGEF1; KALRN; RAPGEFL1; FNIP1; ARHGEF7; PREX1; RINL; ARFGEF2; RASGEF1BB
    myosin binding CALD1; DMD; VEZT; ARFGEF2; SLC6A4; TRIM32; NPHS1; RHOA; KIRREL; SMYD1B
    protein kinase A regulatory subunit binding ARFGEF2; AKAP5; AKAP6; AKAP1; C2orf88; KCNQ1; AKAP9; AKAP7; AKAP8; EZR

    ARFGEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARFGEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARFGEF1.

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