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ARFRP1

  • Official Full Name

    ADP-ribosylation factor related protein 1

  • Overview

    The protein encoded by this gene is a membrane-associated GTP-ase and localizes to the plasma membrane. It is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. The gene is located in a gene cluster that includes the a gene (M68) that is overexpressed in some tumors. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    ARFRP1; ADP-ribosylation factor related protein 1; ADP-ribosylation factor-related protein 1; ARL18; ARP; Arp1; ADP ribosylation factor related protein 1; ARF related protein 1; ARF related protein; ARL 18; ARP 1; Helicase like protein NHL; MGC6837; SCG10 like protein; SCG10 like-protein; ARF-related protein 1; helicase-like protein NHL;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARFRP1-9809H Recombinant Human ARFRP1, GST-tagged E.coli GST 1-201a.a.
Human ARFRP1-755H Recombinant Human ARFRP1 protein, GST-tagged Wheat Germ GST
Human ARFRP1-8748HCL Recombinant Human ARFRP1 293 Cell Lysate HEK293 N/A
Human ARFRP1-1109HF Recombinant Full Length Human ARFRP1 Protein, GST-tagged In Vitro Cell Free System GST 201 amino acids
Human ARFRP1-3452H Recombinant Human ARFRP1 protein, His-tagged E.coli His 1-201 aa
Human ARFRP1-806H Recombinant Human ARFRP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Arfrp1-1677M Recombinant Mouse Arfrp1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat ARFRP1-759R Recombinant Rat ARFRP1 Protein Mammalian Cell His
Rat ARFRP1-415R-B Recombinant Rat ARFRP1 Protein Pre-coupled Magnetic Beads HEK293
Rat ARFRP1-415R Recombinant Rat ARFRP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ARFRP1-2091Z Recombinant Zebrafish ARFRP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ARFRP1 Related Articles

ARFRP1 involved in several pathways and played different roles in them. We selected most pathways ARFRP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARFRP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ARFRP1 has several biochemical functions, for example, GTP binding, GTPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARFRP1 itself. We selected most functions ARFRP1 had, and list some proteins which have the same functions with ARFRP1. You can find most of the proteins on our site.

Function Related Protein
GTP bindingTUBA4A;ARL8A;EEF1A1A;SRP54A;RHOC;SEPT12;RHOGA;RND1L;PPP1CA
GTPase activityTUBB4A;RAB1B;ARL4C;RASD2;RAB35B;RAB4B;RAB19;DNM1L;TRIM23
protein bindingHSPB8;PRRC1;HNRNPA1;KDRL;HIST1H4K;EFHC2;HSPBP1;PPP2R5E;RHOV

ARFRP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARFRP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARFRP1.

pi3p

Shen, XY; Meza-Carmen, V; et al. Interaction of brefeldin A-inhibited guanine nucleotide-exchange protein (BIG) 1 and kinesin motor protein KIF21A. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105:18788-18793(2008).
Padilla, PI; Chang, MJ; et al. Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): Effects of FK506. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100:2322-2327(2003).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
Are there any disease associations linked to ARFRP1? 03/16/2022

Currently, there are no known disease associations directly linked to ARFRP1. However, the dysregulation of ARF family members, including ARFRP1, has been implicated in various diseases such as cancer and neurodegenerative disorders. Further research is needed to fully understand the role of ARFRP1 in these conditions.

Are there any known mutations or genetic variations in the ARFRP1 gene? 03/05/2022

To date, there have been no reported disease-causing mutations or significant genetic variations identified in the ARFRP1 gene. However, genetic studies investigating potential associations between ARFRP1 and certain diseases are ongoing.

Is ARFRP1 involved in any other cellular processes? 02/27/2021

While its primary role appears to be in vesicle trafficking, ARFRP1 has also been implicated in other cellular processes. It has been associated with actin cytoskeleton organization, cell migration, and modulation of cell surface receptors. However, further research is needed to fully understand its involvement in these processes.

Can ARFRP1 be targeted for therapeutic purposes? 02/16/2021

The potential therapeutic targeting of ARFRP1 remains largely unexplored due to limited knowledge about its precise functions and mechanisms. However, as our understanding of ARFRP1 grows, it may present opportunities for the development of drugs or therapeutic approaches that modulate its activity, particularly in diseases associated with aberrant membrane trafficking processes.

How is ARFRP1 involved in vesicle trafficking? 12/12/2020

ARFRP1 participates in vesicle trafficking by regulating the assembly and disassembly of coat proteins on transport vesicles. It is involved in the formation of COPI-coated vesicles, which mediate retrograde transport from the Golgi apparatus back to the ER. ARFRP1 interacts with ARFGAP1, an ARF GTPase-activating protein, to regulate COPI coat assembly and vesicle budding.

Are there any animal models available for studying ARFRP1? 12/06/2020

Currently, there are no specific animal models developed solely for studying ARFRP1. However, studies have explored the effects of ARFRP1 depletion or overexpression in cellular and animal models, shedding light on its functional significance in various biological processes.

Can ARFRP1 be targeted for cancer therapy? 09/21/2020

While there is no direct evidence for targeting ARFRP1 in cancer therapy, aberrant membrane trafficking is a hallmark of cancer progression. Given ARFRP1's involvement in vesicle trafficking and its potential role in tumor development, it may be worth investigating its therapeutic potential in cancer treatment or as a target for drug development in combination with other therapies.

Does ARFRP1 have any known interacting proteins? 04/22/2020

ARFRP1 has been found to interact with various proteins involved in membrane trafficking and vesicle formation. Some of its known interacting partners include COPI (coatomer protein complex I) subunits and proteins associated with clathrin-mediated endocytosis.

Are there any known ARFRP1 knockout or knockdown models? 04/01/2019

Yes, knockout and knockdown models of ARFRP1 have been generated in several organisms for research purposes. These models include genetically modified mice lacking ARFRP1 expression (ARFRP1 knockout mice) and cellular models in which ARFRP1 expression is specifically reduced or silenced (ARFRP1 knockdown models). Using these models, researchers have been able to study the function of ARFRP1 and its role in different cellular processes.

Does ARFRP1 have any post-translational modifications? 05/28/2017

Yes, ARFRP1 can undergo post-translational modifications, including lipidation and phosphorylation. Lipid modification, such as lipid anchor addition, is crucial for ARFRP1's association with membranes. Phosphorylation events may regulate its activity, localization, or interactions with binding partners, although specific details regarding phosphorylation sites and functional consequences are still being explored.

Customer Reviews (8)

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Reviews
12/18/2022

    The outstanding level of customer service adds extra reassurance and confidence in using the ARFRP1 protein for my scientific investigations.

    10/24/2020

      the manufacturer can assist in sourcing complementary reagents and tools, such as specific antibodies or detection systems, to complement the use of ARFRP1 protein in trials.

      09/27/2020

        manufacturers often have a wealth of knowledge and expertise in the field of ARFRP1 protein research.

        12/09/2019

          Collaborative discussions with the manufacturer can also help optimize experimental protocols and provide insights into the best practices in working with ARFRP1.

          11/09/2016

            The ARFRP1 protein offers numerous advantages in trials and research studies, making it an excellent choice for scientists in need of reliable and high-quality experimental materials.

            10/18/2016

              Its unique properties make ARFRP1 an invaluable tool for investigating cellular signaling pathways, protein-protein interactions, and membrane dynamics.

              02/02/2016

                With the ARFRP1 protein and its accompanying technical assistance, I am confident that I can achieve successful outcomes for my research endeavors.

                01/02/2016

                  They can offer specialized formulations, concentrations, or modifications of ARFRP1 protein to suit unique experimental requirements.

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