ARID5A
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Official Full Name
AT rich interactive domain 5A (MRF1-like)
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Overview
Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in;development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 (PubMed;15640446)). -
Synonyms
ARID5A; AT rich interactive domain 5A (MRF1-like); AT-rich interactive domain-containing protein 5A; MRF 1; RP11 363D14; ARID domain containing protein 5A; AT rich interactive domain 5A; AT rich interactive domain 5A (MRF1 like); AT rich interactive domain containing protein 5A; Modulator recognition factor 1; MRF1; RFVG5814; OTTHUMP00000207481; OTTHUMP00000207483; modulator recognition factor I; ARID domain-containing protein 5A; MRF-1; RP11-363D14;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ARID5A-121HCL | Recombinant Human ARID5A cell lysate | N/A | |||
Mouse | ARID5A-1916M | Recombinant Mouse ARID5A Protein | Mammalian Cell | His | ||
Mouse | ARID5A-711M | Recombinant Mouse ARID5A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ARID5A-1820M | Recombinant Mouse ARID5A Protein (1-590 aa), His-tagged | Yeast | His | 1-590 aa | |
Mouse | ARID5A-711M-B | Recombinant Mouse ARID5A Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
- ARID5A Related Articles
ARID5A involved in several pathways and played different roles in them. We selected most pathways ARID5A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARID5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ARID5A has several biochemical functions, for example, DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARID5A itself. We selected most functions ARID5A had, and list some proteins which have the same functions with ARID5A. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | SRRT;XBP1;KIF4;ZNF624;THOC1;CEBPG;HIST1H2AD;IRF1;GTF2F2 |
chromatin binding | EBF2;HOXC13;PRKAA2;EYA3;TGIF1;CDK9;EGR2;SHMT2;SKOR2 |
protein binding | APOBEC3F;MCCC2;GGT1;F11;PITPNC1;RAD23B;ITGA1;RAD1;CDK20 |
transcription factor binding | SP100;SOX8;DNMT1;PARD6A;GTF2F1;KDM1A;HIF1A;GTF2B;TRIB2 |
transcription regulatory region DNA binding | HNF4A;XRCC6;GFI1;FOXH1;HHEX;KLF17;IKZF2;ZNF821;GATA5 |
ARID5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARID5A here. Most of them are supplied by our site. Hope this information will be useful for your research of ARID5A.
ATXN1; SH2D2A
- Q&As
- Reviews
Q&As (12)
Ask a questionARID5A is primarily localized in the nucleus. It contains nuclear localization signals (NLS) that facilitate its transport from the cytoplasm into the nucleus. However, it can also be found in the cytoplasm in certain conditions or cell types.
The potential of targeting ARID5A for therapeutic interventions is an active area of research. Modulating ARID5A expression or activity may have implications for diseases such as cancer, autoimmune disorders, and inflammatory conditions. However, more research is needed to understand the precise mechanisms and the therapeutic potential of targeting ARID5A.
ARID5A is expressed in a variety of tissues, including the immune system, liver, lung, and brain. Its expression levels may vary among different tissues or cell types, indicating potential tissue-specific functions or regulation.
While ARID5A has not been extensively studied in the context of embryonic development, some studies suggest its potential involvement. It has been found to interact with transcription factors that are important for development, such as STAT proteins. Further research is needed to elucidate the specific roles of ARID5A in embryogenesis.
Currently, there are several promising research areas being pursued regarding ARID5A. One area of interest is exploring the therapeutic potential of targeting ARID5A for the treatment of various diseases, such as autoimmune disorders, cancer, and inflammatory conditions. Researchers are investigating small molecule inhibitors or gene silencing approaches to modulate ARID5A activity. Another research focus is uncovering the molecular mechanisms by which ARID5A regulates gene expression and immune responses. This includes studying its interaction partners, signaling pathways, and understanding its role in post-transcriptional gene regulation.
Yes, ARID5A can interact with several proteins and transcription factors. It has been shown to interact with components of the RNA-induced silencing complex (RISC), suggesting a possible involvement in post-transcriptional gene regulation. ARID5A has also been found to interact with various transcription factors, such as STAT1, STAT6, and NF-κB, and modulate their activity.
Yes, animal model studies have provided insights into the function of ARID5A. For example, knockout mice lacking the ARID5A gene have been generated to study its role in immune regulation. These mice display altered immune responses, including impaired production of inflammatory cytokines and defective immune cell activation. Studies using animal models have also highlighted the importance of ARID5A in development, as ARID5A-deficient mice exhibit growth retardation and skeletal abnormalities. These animal models have been valuable in understanding the biological significance of ARID5A in vivo.
The ARID5A gene does have genetic variations and mutations. Single nucleotide polymorphisms (SNPs) have been identified in the ARID5A gene, some of which have been associated with susceptibility to autoimmune diseases and cancer. However, the functional impact of these genetic variations on ARID5A protein function or disease development is still being investigated.
Yes, ARID5A has been found to interact with several proteins. One of its well-known interacting partners is the NF-κB transcription factor, which plays a central role in inflammation and immune responses. ARID5A can form a complex with NF-κB and regulate its activity. ARID5A has also been reported to interact with other proteins involved in immune regulation, such as STAT3 and SP1. Furthermore, ARID5A has been shown to interact with components of the RNA degradation machinery, suggesting its involvement in post-transcriptional gene regulation.
ARID5A has been implicated in various diseases and disorders. Dysregulation of ARID5A has been observed in autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. It has also been linked to inflammation-related conditions, including sepsis and inflammatory bowel disease. Furthermore, aberrant expression of ARID5A has been reported in certain types of cancer and may contribute to tumor progression.
Yes, ARID5A has been found to have alternative splicing isoforms. These isoforms can vary in their expression patterns and may have distinct functions. However, the specific roles and functional differences of these isoforms are still being investigated.
There is evidence to suggest that ARID5A may play a role in cancer development. It has been found to be dysregulated in certain types of cancer, such as breast cancer and hepatocellular carcinoma. Additionally, ARID5A has been shown to influence cell proliferation, apoptosis, and invasion in cancer cell lines. However, further research is needed to fully understand the specific role of ARID5A in cancer biology.
Customer Reviews (8)
Write a reviewthe ARID5A protein exhibits remarkable stability, enabling it to maintain its structural integrity and functionality throughout the experimental process.
Its versatility in various biological applications, coupled with its compatibility with diverse techniques, makes it a preferred reagent for researchers in the field.
Its stability and compatibility with electron microscopy techniques make it an ideal candidate for studying protein structures at high resolution.
As a researcher utilizing the ARID5A protein, I am fortunate to benefit from its numerous advantages in trials.
ARID5A protein is highly recommended for scientific research applications, especially in ELISA assays and protein electron microscopy structure analysis.
the ARID5A protein offers exceptional quality and purity, which is crucial for ensuring reliable and reproducible experimental outcomes.
Scientists who have employed ARID5A protein in their experiments have praised its outstanding performance and reliability.
the manufacturer of the ARID5A protein plays a vital role in supporting my research endeavors.
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