ARPC1A
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Official Full Name
actin related protein 2/3 complex, subunit 1A, 41kDa
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Overview
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ARPC1A; actin related protein 2/3 complex, subunit 1A, 41kDa; actin related protein 2/3 complex, subunit 1A (41 kD); actin-related protein 2/3 complex subunit 1A; actin binding protein (Schizosaccharomyces pombe sop2 like); Arc40; SOP2 like protein; SOP2H;
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- His
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- Involved Pathway
- Protein Function
- Interacting Protein
- ARPC1A Related Articles
ARPC1A involved in several pathways and played different roles in them. We selected most pathways ARPC1A participated on our site, such as Axon guidance, Bacterial invasion of epithelial cells, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Axon guidance | DPYSL4;Ntng2;NCK2;NCAN;PEBP1;RHOGA;COL6A3;NRTN;ROBO2 |
Bacterial invasion of epithelial cells | RHOA;WASF1;ACTB;WAS;BCAR1;RAC1;DNM3;ARPC5L;GAB1 |
Developmental Biology | KCNQ3;SEMA3AA;AP2S1;CEBPA;AP2A2;TDGF1;RHOC;FOXD3;DCC |
EPH-Ephrin signaling | ARPC4;ARPC2;EFNA1A;EFNA3;EPHA2A;DNM1;CFL1;ACTR3;AP2A2 |
EPHB-mediated forward signaling | EFNB2A;ARPC2;KALRNB;EFNB3;EPHB3A;ARPC1A;KALRN;EFNB1;ACTR2 |
Endocytosis | NEDD4;HSC70;SMURF1;ERBB4;SNX32;CYTH1A;CYTH3;RAB7A;HLA-G |
Fc gamma R-mediated phagocytosis | INPP5D;PLCG1;FCGR2A;RPS6KB1;PIK3R5;ASAP1;PIK3CD;LYN;PRKCD |
Fcgamma receptor (FCGR) dependent phagocytosis | NCKAP1;WIPF3;ACTR2;IgG3;ABI1;WASF2;ARPC1A;WASF3;ACTR2B |
ARPC1A has several biochemical functions, for example, actin binding, actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC1A itself. We selected most functions ARPC1A had, and list some proteins which have the same functions with ARPC1A. You can find most of the proteins on our site.
Function | Related Protein |
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actin binding | MICAL2B;SPATA31;SYN1;NRAP;KLHL3;SNTB1;EPS8;SCIN;VMHC |
actin filament binding | LCP1;MYH3;CTNNA2;CORO1CA;MACF1;ESPN;FLNA;TRPV4;CTNNA3 |
ARPC1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC1A here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC1A.
HACD3; ACTR3B; BAG3; Actb; ACTR2; GRB2; DBN1
- Q&As
- Reviews
Q&As (7)
Ask a questionYes, the ARPC1A protein can undergo post-translational modifications, including phosphorylation and acetylation, which may regulate its activity and interactions with other proteins. The specific effects and functional significance of these modifications are still being studied.
Yes, in addition to its association with the other subunits of the Arp2/3 complex, the ARPC1A protein can interact with various actin-binding proteins and regulatory factors. For example, it can associate with WASP (Wiskott-Aldrich syndrome protein) family members, which play a crucial role in actin cytoskeleton regulation.
The ARPC1A protein consists of multiple domains that are involved in protein-protein interactions. It has a predicted alpha-helical coiled-coil domain near the N-terminus, which mediates interactions with other subunits of the Arp2/3 complex. The C-terminus of ARPC1A contains an actin-binding-like domain (ABD) that helps anchor the complex to newly polymerized actin filaments.
The ARPC1A protein interacts with other subunits of the Arp2/3 complex, such as ARPC1B, ARPC2, and ARPC5, to form the functional complex. It also interacts with various actin-binding proteins, regulatory proteins, and signaling molecules that help regulate actin polymerization and participate in specific cellular processes.
Yes, the ARPC1A protein is expressed in most, if not all, cell types. Actin filament nucleation and branching are essential processes for various cellular functions, so the ARPC1A protein is required in a wide range of cell types and tissues.
Yes, mutations in the ARPC1A gene have been linked to a rare genetic disorder called ARPC1A-related intellectual disability, which is characterized by developmental delay, intellectual disability, and distinctive facial features. These mutations can disrupt the normal function of the ARPC1A protein, impairing actin filament nucleation and branching processes.
The activity and expression of the ARPC1A protein can be regulated in multiple ways. It can be regulated at the transcriptional level through various transcription factors and signaling pathways. Post-translational modifications, such as phosphorylation and acetylation, can also regulate its activity. Additionally, the availability of other subunits of the Arp2/3 complex can influence the assembly and stability of the complex, thereby affecting ARPC1A function.
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