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ARPC1A

  • Official Full Name

    actin related protein 2/3 complex, subunit 1A, 41kDa

  • Overview

    This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ARPC1A; actin related protein 2/3 complex, subunit 1A, 41kDa; actin related protein 2/3 complex, subunit 1A (41 kD); actin-related protein 2/3 complex subunit 1A; actin binding protein (Schizosaccharomyces pombe sop2 like); Arc40; SOP2 like protein; SOP2H;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARPC1A-9881H Recombinant Human ARPC1A, GST-tagged E.coli GST 1-370a.a.
Human ARPC1A-844H Recombinant Human ARPC1A protein, GST-tagged Wheat Germ GST
Human ARPC1A-8687HCL Recombinant Human ARPC1A 293 Cell Lysate HEK293 N/A
Human ARPC1A-5138H Recombinant Human ARPC1A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ARPC1A-151H Recombinant Human ARPC1A Protein, His-tagged Human Cells His
Human ARPC1A-1135HF Recombinant Full Length Human ARPC1A Protein, GST-tagged In Vitro Cell Free System GST 370 amino acids
Mouse ARPC1A-1965M Recombinant Mouse ARPC1A Protein Mammalian Cell His
Mouse Arpc1a-1724M Recombinant Mouse Arpc1a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ARPC1A-747M Recombinant Mouse ARPC1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ARPC1A-747M-B Recombinant Mouse ARPC1A Protein Pre-coupled Magnetic Beads HEK293
Rat ARPC1A-797R Recombinant Rat ARPC1A Protein Mammalian Cell His
Rat ARPC1A-453R Recombinant Rat ARPC1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ARPC1A-453R-B Recombinant Rat ARPC1A Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ARPC1A-11488Z Recombinant Zebrafish ARPC1A Mammalian Cell His
Chicken ARPC1A-3534C Recombinant Chicken ARPC1A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ARPC1A Related Articles

ARPC1A involved in several pathways and played different roles in them. We selected most pathways ARPC1A participated on our site, such as Axon guidance, Bacterial invasion of epithelial cells, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceSEMA6D;PAQR3A;RHOB;DUSP1;RASGRP4;NTN1;Plxna2;SEMA3E;ACTR2
Bacterial invasion of epithelial cellsWASF2;CTNNA2;CBL;PIK3CD;ITGA5;SEPT2;DOCK1;PIK3R1;PXN
Developmental BiologyMYF6;BOC;DRAP1;SPRED1;SPTB;RANBP9;DLG3;SCN3B;EFNB2A
EPH-Ephrin signalingAP2A2;EFNB2;ACTR2B;ITSN1;ARPC2;KALRN;MYL12B;CFL1;EPHB3A
EPHB-mediated forward signalingARPC5;KALRN;EFNB1;CFL1;EPHB3A;ARPC3;ITSN1;KALRNB;ARHGEF28
EndocytosisCYTH3;CXCR1;MHC1UXA2;ITCHA;RAB11FIP5;ASAP3;SMAD2;VPS45;CYTH1
Fc gamma R-mediated phagocytosisPIK3R1;LYN;BIN1;PLA2G6;PLD2;MAPK3;ASAP1;FCGR1;WAS
Fcgamma receptor (FCGR) dependent phagocytosisACTR2;BAIAP2;WIPF2;ABI2;IgG3;NCKIPSD;PPAPDC1B;ABI1A;PLD4

ARPC1A has several biochemical functions, for example, actin binding, actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC1A itself. We selected most functions ARPC1A had, and list some proteins which have the same functions with ARPC1A. You can find most of the proteins on our site.

Function Related Protein
actin bindingGSN;ABLIM1B;HCLS1;MYO6;VASPA;SMTN;CNN2;MYH1B;PHACTR3B
actin filament bindingJUB;WIPF3;TMOD4;CORO1B;MYO7A;CORO2B;MYH10;ADSSL1;MYO10

ARPC1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC1A here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC1A.

HACD3; ACTR3B; BAG3; Actb; ACTR2; GRB2; DBN1

Zucchini, C; Manara, MC; et al. CD99 suppresses osteosarcoma cell migration through inhibition of ROCK2 activity. ONCOGENE 33:1912-1921(2014).
Chen, CP; Chang, SJ; et al. Prenatal diagnosis and molecular cytogenetic characterization of a de novo interstitial deletion of 7q (7q22.1 -> q31.1). GENE 521:311-315(2013).
  • Q&As
  • Reviews

Q&As (7)

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Are there any known post-translational modifications of the ARPC1A protein? 01/29/2023

Yes, the ARPC1A protein can undergo post-translational modifications, including phosphorylation and acetylation, which may regulate its activity and interactions with other proteins. The specific effects and functional significance of these modifications are still being studied.

Can the ARPC1A protein form complexes with other protein families apart from the Arp2/3 complex? 10/26/2022

Yes, in addition to its association with the other subunits of the Arp2/3 complex, the ARPC1A protein can interact with various actin-binding proteins and regulatory factors. For example, it can associate with WASP (Wiskott-Aldrich syndrome protein) family members, which play a crucial role in actin cytoskeleton regulation.

What are the structural features of the ARPC1A protein? 10/19/2020

The ARPC1A protein consists of multiple domains that are involved in protein-protein interactions. It has a predicted alpha-helical coiled-coil domain near the N-terminus, which mediates interactions with other subunits of the Arp2/3 complex. The C-terminus of ARPC1A contains an actin-binding-like domain (ABD) that helps anchor the complex to newly polymerized actin filaments.

Are there any known interacting partners of the ARPC1A protein? 03/09/2020

The ARPC1A protein interacts with other subunits of the Arp2/3 complex, such as ARPC1B, ARPC2, and ARPC5, to form the functional complex. It also interacts with various actin-binding proteins, regulatory proteins, and signaling molecules that help regulate actin polymerization and participate in specific cellular processes.

Is the ARPC1A protein expressed in all cell types? 08/15/2019

Yes, the ARPC1A protein is expressed in most, if not all, cell types. Actin filament nucleation and branching are essential processes for various cellular functions, so the ARPC1A protein is required in a wide range of cell types and tissues.

Are there any known diseases or disorders associated with ARPC1A protein dysfunction? 01/11/2019

Yes, mutations in the ARPC1A gene have been linked to a rare genetic disorder called ARPC1A-related intellectual disability, which is characterized by developmental delay, intellectual disability, and distinctive facial features. These mutations can disrupt the normal function of the ARPC1A protein, impairing actin filament nucleation and branching processes.

How is the ARPC1A protein regulated in cells? 04/16/2018

The activity and expression of the ARPC1A protein can be regulated in multiple ways. It can be regulated at the transcriptional level through various transcription factors and signaling pathways. Post-translational modifications, such as phosphorylation and acetylation, can also regulate its activity. Additionally, the availability of other subunits of the Arp2/3 complex can influence the assembly and stability of the complex, thereby affecting ARPC1A function.

Customer Reviews (3)

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Reviews
04/14/2023

    Their dedicated team of experts is prompt, knowledgeable, and readily available to tackle any hurdles or concerns I may encounter.

    12/13/2022

      Used in protein electron microscopy structure analysis.Great.

      11/11/2019

        The ARPC1A protein showcases unparalleled quality, ensuring it surpasses expectations and satisfactorily addresses my experimental requirements.

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