Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

ARPC1B

  • Official Full Name

    actin related protein 2/3 complex, subunit 1B, 41kDa

  • Overview

    This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase.
  • Synonyms

    ARPC1B; actin related protein 2/3 complex, subunit 1B, 41kDa; actin related protein 2/3 complex, subunit 1B (41 kD); actin-related protein 2/3 complex subunit 1B; actin related protein 2/3 complex; subunit 1A (41 kD); ARC41; ARP2/3 protein complex subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • DYKDDDDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARPC1B-3104H Recombinant Human ARPC1B, His-tagged E.Coli or Yeast His 372
Human ARPC1B-845H Recombinant Human ARPC1B protein, GST-tagged Wheat Germ GST
Human ARPC1B-8686HCL Recombinant Human ARPC1B 293 Cell Lysate HEK293 N/A
Human ARPC1B-1102HF Recombinant Full Length Human ARPC1B Protein, GST-tagged In Vitro Cell Free System GST 372 amino acids
Human ARPC1B-1258H Recombinant Human ARPC1B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ARPC1B-380H-B Recombinant Human ARPC1B Protein Pre-coupled Magnetic Beads HEK293
Human ARPC1B-151H Recombinant Human ARPC1B Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human ARPC1B-380H Recombinant Human ARPC1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ARPC1B-3841H Recombinant Human ARPC1B protein, His-tagged E.coli His 265-372 aa
Human ARPC1B-2019HFL Recombinant Full Length Human ARPC1B Protein, C-Flag-tagged Mammalian cells Flag
Mouse ARPC1B-1966M Recombinant Mouse ARPC1B Protein Mammalian Cell His
Mouse ARPC1B-748M Recombinant Mouse ARPC1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ARPC1B-748M-B Recombinant Mouse ARPC1B Protein Pre-coupled Magnetic Beads HEK293
Rat Arpc1b-3103R Recombinant Rat Arpc1b, His-tagged E.Coli or Yeast His 372
Rat ARPC1B-798R Recombinant Rat ARPC1B Protein Mammalian Cell His
Rat ARPC1B-454R Recombinant Rat ARPC1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ARPC1B-454R-B Recombinant Rat ARPC1B Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ARPC1B-12372Z Recombinant Zebrafish ARPC1B Mammalian Cell His
Chicken ARPC1B-2339C Recombinant Chicken ARPC1B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ARPC1B Related Articles

ARPC1B involved in several pathways and played different roles in them. We selected most pathways ARPC1B participated on our site, such as Axon guidance, B Cell Receptor Signaling Pathway, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceANK2B;PAK1;EPHA4;SRGAP3;COL6A3;PAQR3A;PAQR3B;EZRA;PAK7
B Cell Receptor Signaling PathwayMAPK1;DUSP6;IFITM1;TTC6;BLK;CDK2;CD79A;PIK3CB;CSK
Bacterial invasion of epithelial cellsACTG1;DOCK1;PIK3CD;CLTC;WASF1;DNM2;SEPT12;PIK3R3;WASF2
CDC42 signaling eventsARPC3;ACTR3;CDC42BPA;IQGAP3;ACTR2;CFL1;ARPC5;BAIAP2;EPS8
Developmental BiologyLIN28A;MYL9;COL4A4;INSM1B;GDNF;MYF6;KALRNB;EFNB3B;RASGRP1
EPH-Ephrin signalingEFNA5;EFNB1;ITSN1;EFNB2;ARPC3;EPHB4A;MYL12A;AP2S1;ACTR3
EPHB-mediated forward signalingEPHB4B;ACTR3;ARPC3;EFNB2;CFL1;EFNB3;KALRNB;ARHGEF28;EFNB2A
EndocytosisWASLB;HSC70;CSF1R;EGFRA;PIP5K1AB;CYTH4;KIF5C;ADRB3A;SH3GL3B

ARPC1B has several biochemical functions, for example, contributes_to actin filament binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC1B itself. We selected most functions ARPC1B had, and list some proteins which have the same functions with ARPC1B. You can find most of the proteins on our site.

Function Related Protein
contributes_to actin filament bindingARPC5;MYH10;ARPC2;ARPC3;ACTR2;ARPC4;ACTR3;MYH9;ARPC1B
structural constituent of cytoskeletonTUBGCP2;TUBB1;MAPT;KRT2;ACTR2;AGRN;SPTA1;TUBA1B;SORBS3

ARPC1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC1B here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC1B.

WAS; WASL; SRPK2; ACTR3B; q81y32_bacan; q81yf9_bacan; Cenpe; MYO1C; Kif3c; Itga5; FLNA; CDK2; MYH9; CRK; CAPZA2; Tpm1

Jin, LJ; Wu, ZR; et al. Identifying gene expression profile of spinal cord injury in rat by bioinformatics strategy. MOLECULAR BIOLOGY REPORTS 41:3169-3177(2014).
Rauhala, HE; Teppo, S; et al. Silencing of the ARP2/3 Complex Disturbs Pancreatic Cancer Cell Migration. ANTICANCER RESEARCH 33:45-52(2013).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What diseases or disorders have been associated with dysregulation of the ARPC1B protein? 03/08/2023

Dysregulation of the ARPC1B protein has been implicated in various types of cancer, including breast cancer and colorectal cancer. Additionally, mutations or deletions in the ARPC1B gene have been linked to developmental disorders such as intellectual disability and abnormal brain development.

How does the ARPC1B protein contribute to cancer progression? 11/07/2022

The ARPC1B protein is involved in cancer progression by promoting cell motility, invasion, and metastasis. It functions within the Arp2/3 complex to facilitate the formation of actin-based protrusions that allow cancer cells to move and invade surrounding tissues.

Can modulation of the ARPC1B protein be considered as a potential therapeutic approach? 02/07/2021

Modulation of the ARPC1B protein or its associated Arp2/3 complex could be a potential therapeutic approach for diseases involving aberrant actin cytoskeleton dynamics or cellular motility. However, further research is necessary to fully understand the functional consequences of ARPC1B dysregulation and to develop targeted therapeutic strategies.

Are there any ARPC1B inhibitors or potential therapeutic targets? 06/29/2018

Currently, there are no specific inhibitors targeting the ARPC1B protein available for therapeutic use. However, as the Arp2/3 complex is an essential component of actin cytoskeleton regulation, inhibitors targeting the interaction between the complex and its activators may hold potential as anti-cancer agents.

What role does the ARPC1B protein play in brain development and intellectual disability? 02/08/2018

ARPC1B is expressed in the developing brain and is crucial for proper neuronal migration and cortical development. Mutations or deletions in the ARPC1B gene have been associated with intellectual disability and cortical malformations, which are thought to result from disrupted actin dynamics impairing the normal development and function of neural circuits.

Are there any known drugs or therapeutic approaches targeting ARPC1B? 09/17/2017

Currently, there are no specific drugs or therapeutic interventions targeting ARPC1B. However, as ARPC1B is involved in actin dynamics and cell migration, targeting other components of the actin cytoskeleton or signaling pathways that regulate actin polymerization may indirectly impact ARPC1B function and could be explored as potential therapeutic strategies.

Customer Reviews (3)

Write a review
Reviews
02/18/2023

    Their team of experts is highly knowledgeable, responsive, and dedicated to providing prompt solutions to any challenges I may face.

    06/25/2021

      By harnessing the power of the ARPC1B protein, I can harness its outstanding quality and tap into its potential to obtain dependable and meaningful findings.

      11/01/2018

        The ARPC1B protein is undoubtedly a superior choice, boasting extraordinary quality that guarantees it will fulfill all my experimental requirements.

        Ask a Question for All ARPC1B Products

        Required fields are marked with *

        My Review for All ARPC1B Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends