ARPC1B
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Official Full Name
actin related protein 2/3 complex, subunit 1B, 41kDa
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Overview
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. -
Synonyms
ARPC1B; actin related protein 2/3 complex, subunit 1B, 41kDa; actin related protein 2/3 complex, subunit 1B (41 kD); actin-related protein 2/3 complex subunit 1B; actin related protein 2/3 complex; subunit 1A (41 kD); ARC41; ARP2/3 protein complex subunit;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
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- E.coli
- E.Coli or Yeast
- HEK293
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- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- DYKDDDDK
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ARPC1B Related Articles
ARPC1B involved in several pathways and played different roles in them. We selected most pathways ARPC1B participated on our site, such as Axon guidance, B Cell Receptor Signaling Pathway, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Axon guidance | KALRN;AP2S1;COL4A3;IL17RD;KCNQ3;PPP3CB;CXCR4;NRG3;SEMA6C |
B Cell Receptor Signaling Pathway | CD79B;RAP2A;FCGR2B;LIME1;PILRB;NFKBIE;cgr2b;Cd79a, Cd79b;PLEKHA2 |
Bacterial invasion of epithelial cells | SEPT3;ARPC5L;WASL;PXN;WASF2;SRC;SEPT2;CTNNA2;CLTB |
CDC42 signaling events | ARPC5;EPS8;ARPC4;CFL1;IQGAP3;TNK2;ACTR2;ARPC2;CTNNA1 |
Developmental Biology | EFNA4;LGI4;SEMA3A;CAP1;RASGEF1A;EPHA4A;DRAP1;MYL12B;GFRA4 |
EPH-Ephrin signaling | EFNA1A;EFNA2A;EPHB4B;KALRNB;ARPC5;SDCBP;EPHA10;CLTC;EPHA2 |
EPHB-mediated forward signaling | ACTR2B;ARPC5;CFL1;KALRN;ARPC2;EFNB1;EFNB3B;EPHB4B;ACTR2 |
Endocytosis | RNF103-CHMP3;WIPF1A;SH3GL2;ARPC5B;WASLA;ZFP652;CDC42L2;HSPA6;RHOAA |
ARPC1B has several biochemical functions, for example, contributes_to actin filament binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC1B itself. We selected most functions ARPC1B had, and list some proteins which have the same functions with ARPC1B. You can find most of the proteins on our site.
Function | Related Protein |
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contributes_to actin filament binding | ACTR2;ARPC3;ARPC1B;ARPC4;ARPC5;ARPC2;MYH9;ACTR3;MYH10 |
structural constituent of cytoskeleton | COX4I2;YEATS4;TUBA1A;KRT20;ACTL7B;CCDC6;SPRR2A1;DSP;NEFH |
ARPC1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC1B here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC1B.
WAS; WASL; SRPK2; ACTR3B; q81y32_bacan; q81yf9_bacan; Cenpe; MYO1C; Kif3c; Itga5; FLNA; CDK2; MYH9; CRK; CAPZA2; Tpm1
- Q&As
- Reviews
Q&As (6)
Ask a questionDysregulation of the ARPC1B protein has been implicated in various types of cancer, including breast cancer and colorectal cancer. Additionally, mutations or deletions in the ARPC1B gene have been linked to developmental disorders such as intellectual disability and abnormal brain development.
The ARPC1B protein is involved in cancer progression by promoting cell motility, invasion, and metastasis. It functions within the Arp2/3 complex to facilitate the formation of actin-based protrusions that allow cancer cells to move and invade surrounding tissues.
Modulation of the ARPC1B protein or its associated Arp2/3 complex could be a potential therapeutic approach for diseases involving aberrant actin cytoskeleton dynamics or cellular motility. However, further research is necessary to fully understand the functional consequences of ARPC1B dysregulation and to develop targeted therapeutic strategies.
Currently, there are no specific inhibitors targeting the ARPC1B protein available for therapeutic use. However, as the Arp2/3 complex is an essential component of actin cytoskeleton regulation, inhibitors targeting the interaction between the complex and its activators may hold potential as anti-cancer agents.
ARPC1B is expressed in the developing brain and is crucial for proper neuronal migration and cortical development. Mutations or deletions in the ARPC1B gene have been associated with intellectual disability and cortical malformations, which are thought to result from disrupted actin dynamics impairing the normal development and function of neural circuits.
Currently, there are no specific drugs or therapeutic interventions targeting ARPC1B. However, as ARPC1B is involved in actin dynamics and cell migration, targeting other components of the actin cytoskeleton or signaling pathways that regulate actin polymerization may indirectly impact ARPC1B function and could be explored as potential therapeutic strategies.
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