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ARPC4

  • Official Full Name

    actin related protein 2/3 complex, subunit 4

  • Overview

    This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein.
  • Synonyms

    ARPC4; actin related protein 2/3 complex, subunit 4; actin-related protein 2/3 complex subunit 4; Actin related protein 2/3 complex subunit 4; Actin related protein 2/3 complex subunit 4 20 kD; Actin related protein 2/3 complex subunit 4 20kDa; ARC20; Arp2/3 complex 20 kDa subunit; Arp2/3 protein complex subunit p20; ARPC 4; ARPC4_HUMAN; MGC13544; OTTHUMP00000165252; OTTHUMP00000207520; p20 Arc; p20-ARC; p20ARC; 20kDa; AI327076; 5330419I20Rik;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARPC4-300H Recombinant Human ARPC4 Protein, His-tagged E.coli His
Human ARPC4-9885H Recombinant Human ARPC4, GST-tagged E.coli GST 1-168a.a.
Human ARPC4-848H Recombinant Human ARPC4 protein, GST-tagged Wheat Germ GST
Human ARPC4-8684HCL Recombinant Human ARPC4 293 Cell Lysate HEK293 N/A
Human ARPC4-151H Recombinant Human ARPC4 Protein, His-tagged Human Cells His
Human ARPC4-1100HF Recombinant Full Length Human ARPC4 Protein, GST-tagged In Vitro Cell Free System GST 78 amino acids
Human ARPC4-0532H Recombinant Human ARPC4 Protein (Ala3-Leu165), N-His-tagged E.coli N-His Ala3-Leu165
Mouse Arpc4-3106M Recombinant Mouse Arpc4, His-tagged E.Coli or Yeast His 91
Mouse ARPC4-3088M Recombinant Mouse ARPC4, His-tagged E.coli His 91
Mouse Arpc4-1694M Recombinant Mouse Arpc4 protein, His-tagged E.coli His Ala79~Phe164 (Accession # P59999)
Rat Arpc4-1695R Recombinant Rat Arpc4 protein, His-tagged E.coli His Ala3~Glu163 (Accession # B2RZ72)
Zebrafish ARPC4-11585Z Recombinant Zebrafish ARPC4 Mammalian Cell His
Chicken ARPC4-4611C Recombinant Chicken ARPC4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ARPC4 Related Articles

ARPC4 involved in several pathways and played different roles in them. We selected most pathways ARPC4 participated on our site, such as Axon guidance, B Cell Receptor Signaling Pathway, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceNFATC2;KIF4A;SPNA1;EFNA3;UNC5C;CFL1;PITPNA;SLIT1;SEMA3B
B Cell Receptor Signaling PathwayMAPK3;CSK;CRK;NFKBIB;VAV1;ARPC4;PIK3R1;SLA2;NFKB1
Bacterial invasion of epithelial cellsSEPT11;PXN;CTNNA3;CDC42;HCLS1;ARPC3;SEPT2;ELMO1;ARPC2
CDC42 signaling eventsPAK4;BAIAP2;EPS8;CDC42BPA;ARPC3;ARPC1B;IQGAP3;ARPC5;ACTR2
Developmental BiologySPRED1;FGF18B;DPYSL5A;CD24;GFRA4;MED9;LGI2A;CDON;EFNA2A
EPH-Ephrin signalingEFNA1B;EFNA2A;EFNB2;EFNA1A;EPHB3A;ARPC3;CLTC;EFNA4;CFL1
EPHB-mediated forward signalingKALRNB;EFNB3;EPHB4A;ARHGEF28;EFNB3B;ARPC5;ITSN1;ARPC1B;ARPC1A
EndocytosisCHMP2B;STRUMPELLIN;MDM2;RAB35B;CYTH1A;ADRB2A;ARFGAP1;ARPC5LA;VPS4A

ARPC4 has several biochemical functions, for example, contributes_to actin filament binding, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC4 itself. We selected most functions ARPC4 had, and list some proteins which have the same functions with ARPC4. You can find most of the proteins on our site.

Function Related Protein
contributes_to actin filament bindingACTR3;ARPC5;ARPC2;MYH9;ARPC3;ARPC1B;ARPC4;MYH10;ACTR2
enzyme bindingNKX2-1;RYR2;NR5A1;RPS3;MDM4;PCCA;PLSCR1;CAT;SCN5A
protein bindingAPOBEC2B;MPZL1;INTS4;WDR18;DNAJC10;POLDIP2;MORN3;PLCB4;MKKS
contributes_to protein binding, bridging
structural constituent of cytoskeletonTUBB6;ACTB;KRT15;VILL;TUBD1;KRT2;SPTA1;KRT6B;INA

ARPC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC4.

PNMA5; EIF1B; ACTR3B; malS; pepF1; RNF130; NELFCD; ARPC5L; ere_dna; FN1; VCAM1; FLNA; MYH9; WAS

Li, X; Li, JH; et al. ARP2/3 complex-mediated actin dynamics is required for hydrogen peroxide-induced stomatal closure in Arabidopsis. PLANT CELL AND ENVIRONMENT 37:1548-1560(2014).
Petchampai, N; Sunyakumthorn, P; et al. Novel Identification of Dermacentor variabilis Arp2/3 Complex and Its Role in Rickettsial Infection of the Arthropod Vector. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
Can ARPC4 expression be regulated by extracellular signals? 08/27/2022

Yes, ARPC4 expression can be influenced by extracellular signals. Various signaling pathways, such as the Rho GTPase pathway and growth factor signaling, can activate or inhibit the expression of genes encoding ARPC4 and other subunits of the ARP2/3 complex, thereby modulating actin cytoskeleton dynamics.

Are there any known drugs or compounds that can modulate ARPC4 activity? 02/17/2021

At present, there are no specific drugs or compounds known to directly modulate ARPC4 activity. However, targeting actin cytoskeleton dynamics and actin regulatory proteins that indirectly affect ARPC4 function has shown potential in preclinical studies as therapeutic approaches for various diseases.

Are there any diseases associated with mutations in the ARPC4 gene? 01/05/2018

Mutations in the ARPC4 gene have not been directly linked to any specific diseases. However, dysregulation of the ARP2/3 complex, including ARPC4, has been implicated in several pathological conditions such as cancer metastasis, neurological disorders, and immune system dysfunction.

Is ARPC4 expression specific to certain cell types or tissues? 09/24/2017

ARPC4 is considered a ubiquitously expressed protein, meaning it is expressed in a wide range of tissues and cell types throughout the body. Its expression is necessary for essential cellular processes involving actin cytoskeleton dynamics.

Are there any known interacting proteins with ARPC4? 01/09/2017

Yes, ARPC4 interacts with other subunits of the ARP2/3 complex, including ARPC1, ARPC2, ARPC3, ARPC5, and ARPC6. Additionally, ARPC4 can interact with actin-binding proteins, such as cortactin and coronin, which regulate actin filament assembly and stability.

Can changes in ARPC4 expression levels affect cell migration? 08/05/2016

Yes, alterations in ARPC4 expression levels can impact cell migration. The ARP2/3 complex, including ARPC4, is essential for actin filament nucleation and branching, which are crucial for cell motility. Changes in ARPC4 expression can disrupt proper actin cytoskeletal dynamics, impairing cell migration.

Can changes in ARPC4 expression affect cell division? 05/06/2016

Yes, changes in ARPC4 expression can impact cell division. The ARP2/3 complex, including ARPC4, is involved in actin-dependent processes during cell division, such as cytokinesis and chromosome segregation. Disruption of ARPC4 expression can lead to defects in these cellular processes.

Customer Reviews (3)

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Reviews
01/15/2021

    Renowned for its reliability and consistency, this protein offers researchers the confidence to achieve accurate and reproducible results in their studies.

    06/15/2017

      One notable advantage of the ARPC4 protein is the excellent technical support provided by its manufacturer.

      02/17/2016

        The ARPC4 protein is known for its exceptional quality, making it a highly suitable choice for meeting diverse experimental needs.

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