ARPC4
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Official Full Name
actin related protein 2/3 complex, subunit 4
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Overview
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. -
Synonyms
ARPC4; actin related protein 2/3 complex, subunit 4; actin-related protein 2/3 complex subunit 4; Actin related protein 2/3 complex subunit 4; Actin related protein 2/3 complex subunit 4 20 kD; Actin related protein 2/3 complex subunit 4 20kDa; ARC20; Arp2/3 complex 20 kDa subunit; Arp2/3 protein complex subunit p20; ARPC 4; ARPC4_HUMAN; MGC13544; OTTHUMP00000165252; OTTHUMP00000207520; p20 Arc; p20-ARC; p20ARC; 20kDa; AI327076; 5330419I20Rik;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- Human Cells
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ARPC4-300H | Recombinant Human ARPC4 Protein, His-tagged | E.coli | His | ||
Human | ARPC4-9885H | Recombinant Human ARPC4, GST-tagged | E.coli | GST | 1-168a.a. | |
Human | ARPC4-848H | Recombinant Human ARPC4 protein, GST-tagged | Wheat Germ | GST | ||
Human | ARPC4-8684HCL | Recombinant Human ARPC4 293 Cell Lysate | HEK293 | N/A | ||
Human | ARPC4-151H | Recombinant Human ARPC4 Protein, His-tagged | Human Cells | His | ||
Human | ARPC4-1100HF | Recombinant Full Length Human ARPC4 Protein, GST-tagged | In Vitro Cell Free System | GST | 78 amino acids | |
Human | ARPC4-0532H | Recombinant Human ARPC4 Protein (Ala3-Leu165), N-His-tagged | E.coli | N-His | Ala3-Leu165 | |
Mouse | Arpc4-3106M | Recombinant Mouse Arpc4, His-tagged | E.Coli or Yeast | His | 91 | |
Mouse | ARPC4-3088M | Recombinant Mouse ARPC4, His-tagged | E.coli | His | 91 | |
Mouse | Arpc4-1694M | Recombinant Mouse Arpc4 protein, His-tagged | E.coli | His | Ala79~Phe164 (Accession # P59999) | |
Rat | Arpc4-1695R | Recombinant Rat Arpc4 protein, His-tagged | E.coli | His | Ala3~Glu163 (Accession # B2RZ72) | |
Zebrafish | ARPC4-11585Z | Recombinant Zebrafish ARPC4 | Mammalian Cell | His | ||
Chicken | ARPC4-4611C | Recombinant Chicken ARPC4 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- ARPC4 Related Articles
ARPC4 involved in several pathways and played different roles in them. We selected most pathways ARPC4 participated on our site, such as Axon guidance, B Cell Receptor Signaling Pathway, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Axon guidance | AP2B1;SCN2B;NRP1A;RAC1;L1CAM;SEMA3A;SEMA3AB;NTN4;EPHA10 |
B Cell Receptor Signaling Pathway | CR2;ARPC1B;IKBKB;SLA2;ARPC3;PIK3CA;PPP3CC;PIK3R1;NEDD9 |
Bacterial invasion of epithelial cells | ARPC1B;CAV2;MET;CTTN;SEPT11;HCLS1;CLTB;ELMO3;CTNNA1 |
CDC42 signaling events | ARPC1B;ACTR3;IQGAP3;BAIAP2;TNK2;ACTR2;ARPC2;CTNNA1;EPS8 |
Developmental Biology | COL9A3;CHL1;RNF8;MYF6;SEMA3AA;ADAM23;NTN1A;CDON;NRTN |
EPH-Ephrin signaling | EFNA1B;EPHA2;EPHA4A;EFNA5;EPHB3A;SDCBP;SHB;ARPC5;EFNB2 |
EPHB-mediated forward signaling | ARPC2;CFL1;KALRNB;EPHB3A;ARPC4;EFNB3B;EFNB3;ACTR3;EFNB1 |
Endocytosis | PSD4;ARPC1A;AP2M1A;WIPF2;ACAP3B;SNF8;ADRB3B;SPG21;ARRB2B |
ARPC4 has several biochemical functions, for example, contributes_to actin filament binding, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC4 itself. We selected most functions ARPC4 had, and list some proteins which have the same functions with ARPC4. You can find most of the proteins on our site.
Function | Related Protein |
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contributes_to actin filament binding | MYH10;ARPC4;ARPC5;ARPC1B;ACTR3;ARPC2;ACTR2;ARPC3;MYH9 |
enzyme binding | ATP2A2;AXIN2;MSH2;ZNHIT6;BTG1;HSPA5;CYP2C19;ATG3;PPP3CA |
protein binding | AZGP1;ACP1;RAP2A;BTC;GFI1;ATP6V1E2;PSMB3;SP140;TATDN1 |
contributes_to protein binding, bridging | |
structural constituent of cytoskeleton | TUBB4B;KRT6B;ACTG1;EPB41L4B;DES;BFSP1;EPB41L3;PLS1;LOR |
ARPC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC4.
PNMA5; EIF1B; ACTR3B; malS; pepF1; RNF130; NELFCD; ARPC5L; ere_dna; FN1; VCAM1; FLNA; MYH9; WAS
- Q&As
- Reviews
Q&As (7)
Ask a questionYes, ARPC4 expression can be influenced by extracellular signals. Various signaling pathways, such as the Rho GTPase pathway and growth factor signaling, can activate or inhibit the expression of genes encoding ARPC4 and other subunits of the ARP2/3 complex, thereby modulating actin cytoskeleton dynamics.
At present, there are no specific drugs or compounds known to directly modulate ARPC4 activity. However, targeting actin cytoskeleton dynamics and actin regulatory proteins that indirectly affect ARPC4 function has shown potential in preclinical studies as therapeutic approaches for various diseases.
Mutations in the ARPC4 gene have not been directly linked to any specific diseases. However, dysregulation of the ARP2/3 complex, including ARPC4, has been implicated in several pathological conditions such as cancer metastasis, neurological disorders, and immune system dysfunction.
ARPC4 is considered a ubiquitously expressed protein, meaning it is expressed in a wide range of tissues and cell types throughout the body. Its expression is necessary for essential cellular processes involving actin cytoskeleton dynamics.
Yes, ARPC4 interacts with other subunits of the ARP2/3 complex, including ARPC1, ARPC2, ARPC3, ARPC5, and ARPC6. Additionally, ARPC4 can interact with actin-binding proteins, such as cortactin and coronin, which regulate actin filament assembly and stability.
Yes, alterations in ARPC4 expression levels can impact cell migration. The ARP2/3 complex, including ARPC4, is essential for actin filament nucleation and branching, which are crucial for cell motility. Changes in ARPC4 expression can disrupt proper actin cytoskeletal dynamics, impairing cell migration.
Yes, changes in ARPC4 expression can impact cell division. The ARP2/3 complex, including ARPC4, is involved in actin-dependent processes during cell division, such as cytokinesis and chromosome segregation. Disruption of ARPC4 expression can lead to defects in these cellular processes.
Customer Reviews (3)
Write a reviewRenowned for its reliability and consistency, this protein offers researchers the confidence to achieve accurate and reproducible results in their studies.
One notable advantage of the ARPC4 protein is the excellent technical support provided by its manufacturer.
The ARPC4 protein is known for its exceptional quality, making it a highly suitable choice for meeting diverse experimental needs.
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