arpc4
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  • Official Full Name
  • actin related protein 2/3 complex, subunit 4
  • Background
  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein.
  • Synonyms
  • ARPC4; actin related protein 2/3 complex, subunit 4; actin-related protein 2/3 complex subunit 4; Actin related protein 2/3 complex subunit 4; Actin related protein 2/3 complex subunit 4 20 kD; Actin related protein 2/3 complex subunit 4 20kDa; ARC20; Arp2/3 complex 20 kDa subunit; Arp2/3 protein complex subunit p20; ARPC 4; ARPC4_HUMAN; MGC13544; OTTHUMP00000165252; OTTHUMP00000207520; p20 Arc; p20-ARC; p20ARC; 20kDa; AI327076; 5330419I20Rik
Cat.#:ARPC4-300HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ARPC4 Protein, His-tagged
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Cat.#:ARPC4-848HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ARPC4 protein, GST-tagged
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Cat.#:ARPC4-9885HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ARPC4, GST-tagged
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Cat.#:Arpc4-1694MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Arpc4 protein, His-tagged
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Cat.#:ARPC4-3088MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse ARPC4, His-tagged
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Cat.#:Arpc4-3106MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Arpc4, His-tagged
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Cat.#:Arpc4-1695RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Arpc4 protein, His-tagged
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Cat.#:ARPC4-4611CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ARPC4
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Cat.#:ARPC4-11585ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ARPC4
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Cat.#:ARPC4-8684HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ARPC4 293 Cell Lysate
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Involved Pathway

ARPC4 involved in several pathways and played different roles in them. We selected most pathways ARPC4 participated on our site, such as Axon guidance, B Cell Receptor Signaling Pathway, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
SEMA7A; SPTBN2; RAC3; SEMA5A; CRMP1; PTPRA; NRG3; Plxna2; PAK1; CD24
B Cell Receptor Signaling Pathway
CR2; cgr2b; ACTR3; DUSP4; AKT2; SYK; NRAS; RAC1; DUSP6; FCGR2B
Bacterial invasion of epithelial cells
MAD2L2; PIK3R2; SEPT9; CBL; CTNNA3; PIK3CG; ITGA5; ACTB; ARPC5L; FN1
CDC42 signaling events
CFL1; CTNNA1; ARPC1B; ACTR2; BAIAP2; PAK4; TNK2; EPS8; ACTR3; ARPC4
Developmental Biology
DUSP5; MED10; RASGEF1A; KIF4A; SPAG9; RND1L; DNM2; PEA15; PLXNC1; RGMB
EPH-Ephrin signaling
EFNA3B; ARPC1A; EPHB3A; EFNA5; EFNB3; ARPC4; SDCBP; AP2S1; EFNB2A; MYL9
EPHB-mediated forward signaling
KALRNB; ARPC3; EFNB2; ARPC5; EFNB1; ARHGEF28; ITSN1; EPHB4B; ARPC1B; KALRN
Endocytosis
HSPA8; ARPC4L; SMAP1; FAM21C; ZFYVE20; RAB35; FLT1; ADRBK2; LDLRAP1; SNX12

Protein Function

ARPC4 has several biochemical functions, for example, contributes_to actin filament binding, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC4 itself. We selected most functions ARPC4 had, and list some proteins which have the same functions with ARPC4. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to actin filament binding
Related Protein ACTR2; ACTR3; ARPC2; MYH10; ARPC5; MYH9; ARPC3; ARPC1B; ARPC4
Function enzyme binding
Related Protein BACE1; KRT79; MAPK8; GOT2; MLL5; CAT; TTN; CBX1; PRTN3; Slc4a2
Function protein binding
Related Protein STAR; KIAA1267; C6orf130; LOXL3; ETV6; AGTR1; ZNF502; ATP6V1H; GTF2H2; SRPK1
Function contributes_to protein binding, bridging
Related Protein ARPC4
Function structural constituent of cytoskeleton
Related Protein LOR; TUBB2B; TUBA8; TUBB2A; VIM; TUBG1; TUBA1B; TPM1; VILL; CYLC1

Interacting Protein

ARPC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC4.
PNMA5; EIF1B; ACTR3B; malS; pepF1; RNF130; NELFCD; ARPC5L; ere_dna; FN1; VCAM1; FLNA; MYH9; WAS

ARPC4 Related Articles

Li, X; Li, JH; et al. ARP2/3 complex-mediated actin dynamics is required for hydrogen peroxide-induced stomatal closure in Arabidopsis. PLANT CELL AND ENVIRONMENT 37:1548-1560(2014).
Petchampai, N; Sunyakumthorn, P; et al. Novel Identification of Dermacentor variabilis Arp2/3 Complex and Its Role in Rickettsial Infection of the Arthropod Vector. PLOS ONE 9:-(2014).