Arrdc3
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Official Full Name
arrestin domain containing 3
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Involved Pathway
- Protein Function
- Interacting Protein
Arrdc3 involved in several pathways and played different roles in them. We selected most pathways Arrdc3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Arrdc3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Arrdc3 has several biochemical functions, for example, beta-3 adrenergic receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Arrdc3 itself. We selected most functions Arrdc3 had, and list some proteins which have the same functions with Arrdc3. You can find most of the proteins on our site.
Function | Related Protein |
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beta-3 adrenergic receptor binding | ARRDC3;ADRB3 |
Arrdc3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Arrdc3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Arrdc3.
- Q&As
- Reviews
Q&As (11)
Ask a questionYes, ARRDC3 can be subjected to post-translational modifications, although the specific modifications are not well-documented. Phosphorylation has been reported to regulate its cellular localization and function in certain contexts.
Yes, ARRDC3 has been found to interact with proteins such as beta-arrestins, clathrin, and several G protein-coupled receptors (GPCRs). These interactions suggest its involvement in GPCR signaling and endocytic processes.
There is emerging evidence suggesting a potential role for ARRDC3 in cancer, particularly hepatocellular carcinoma (HCC). It has been found to be downregulated in HCC, and its overexpression can inhibit HCC cell proliferation and invasion.
Yes, several studies have implicated ARRDC3 in cardiac diseases, such as heart failure and arrhythmias. Its expression has been found to be altered in diseased hearts, and its overexpression has been associated with cardiac dysfunction in mouse models.
Genetic variants or mutations in the ARRDC3 gene have been reported in some studies. These variations may be associated with certain diseases or phenotypic traits, but further research is required to determine their functional significance.
ARRDC3 is evolutionarily conserved, meaning it is found in different species, including mammals, birds, and fish. The level of sequence conservation varies, with certain regions being more conserved than others.
Studies have shown that ARRDC3 can modulate the expression of genes involved in lipid metabolism and adipogenesis. It affects the differentiation of pre-adipocytes into mature adipocytes and can regulate the activity of key transcription factors involved in adipogenesis.
The role of ARRDC3 in disease is still being investigated. Some studies have suggested its involvement in cardiovascular diseases, including heart failure and arrhythmias. It has also been implicated in hepatocellular carcinoma and insulin resistance. However, more research is needed to establish the exact relationship between ARRDC3 and these pathological conditions.
ARRDC3 has the ability to interact with various proteins, including components of the endocytic machinery, membrane receptors, and adaptor proteins. These interactions likely contribute to its role in protein trafficking and signaling pathways.
The therapeutic potential of ARRDC3 is still an area of active research. Its involvement in various cellular processes and disease pathways suggests that it could be a potential target for therapeutic interventions. However, more studies are needed to uncover its precise molecular mechanisms and evaluate its viability as a therapeutic target.
The regulation of ARRDC3 expression is not well-characterized. However, studies suggest that it can be influenced by factors such as transcriptional regulation and cellular signaling pathways. Further research is needed to understand the precise mechanisms involved in the regulation of ARRDC3 expression.
Customer Reviews (3)
Write a reviewTheir unwavering commitment to customer satisfaction assures me that any challenges or queries I may encounter will be expertly resolved.
I am confident that the ARRDC3 protein will unlock vital insights into cellular processes, propelling my scientific investigations to new heights.
An additional advantage of selecting the ARRDC3 protein is the outstanding technical support offered by its manufacturer.
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