ARSD
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Official Full Name
arylsulfatase D
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Overview
The protein encoded by this gene is a member of the sulfatase family. Sulfatases are essential for the correct composition of bone and cartilage matrix. The encoded protein is postranslationally glycosylated and localized to the lysosome. This gene is located within a cluster of similar arylsulfatase genes on chromosome X. A related pseudogene has been identified in the pseudoautosomal region of chromosome Y. -
Synonyms
ARSD; arylsulfatase D; ASD; EC 3.1.6; OTTHUMP00000022848; OTTHUMP00000022849;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ARSD-3660H | Recombinant Human ARSD, His-tagged | E.Coli or Yeast | His | 593 |
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| Human | ARSD-8676HCL | Recombinant Human ARSD 293 Cell Lysate | HEK293 | N/A |
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| Human | ARSD-1748H | Recombinant Human ARSD Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Human | ARSD-3278H | Recombinant Human ARSD protein, His-tagged | E.coli | His | 242 - 593 aa |
- Involved Pathway
- Protein Function
- Interacting Protein
ARSD involved in several pathways and played different roles in them. We selected most pathways ARSD participated on our site, such as Estrogen metabolism, Gamma carboxylation, hypusine formation and arylsulfatase activation, Glycosphingolipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARSD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Estrogen metabolism | COMT;CYP1A1;ARSE;ARSD;NQO1;CYP1B1 |
| Gamma carboxylation, hypusine formation and arylsulfatase activation | ARSI;EIF5A;DPH3;ARSJ;PROCA;ATPBD4;ARSD;DOHH;ARSF |
| Glycosphingolipid metabolism | SUMF2;GLTP;ARSH;NEU4;ARSJ;ARSD;CPTP;ARSK;ARSI |
| Metabolism | PNP5B;BHMT2;LYRM4;CTRC;B4GALT7;SULT2ST1;ZDHHC21;SLC19A2;PFKLB |
| Metabolism of lipids and lipoproteins | PPM1LA;AKR1C4;SLC27A2A;VAPB;ARSE;CYP4T8;PITPNB;STARD5;AKR1B15 |
| Metabolism of proteins | PIGK;EIF4H;ADAMTS13;TRAPPC2;DPH2;ARSF;SUMF2;DNAJB9;INHBAA |
| Post-translational protein modification | BET1;ARSK;SLC35A1;MIA3;ARSF;MUC4;MGAT4B;MGAT4A;EIF5A |
| Sphingolipid metabolism | ARSD;COL4A3BP;CERK;ACER1;LASS4;NEU3.2;GAL3ST1A;ASAH2;UGT8A |
ARSD has several biochemical functions, for example, arylsulfatase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARSD itself. We selected most functions ARSD had, and list some proteins which have the same functions with ARSD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| arylsulfatase activity | ARSD;ARSB;ARSJ;ARSF;ARSA;SULF2;ARSK;ARSI;ARSG |
| metal ion binding | CYP26C1;TRIM101;DNAJA3B;GNAZ;ITGB7;NEK11;TNKS2;FDX1L;ZFP740 |
ARSD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARSD here. Most of them are supplied by our site. Hope this information will be useful for your research of ARSD.
- Q&As
- Reviews
Q&As (5)
Ask a questionWhile the precise role of ARSD in specific biological pathways is still under investigation, it is known to participate in the breakdown of sulfated molecules within lysosomes, contributing to normal cellular metabolism and recycling of molecules.
Currently, there are no specific inhibitors or activators that have been developed for the ARSD protein. However, general inhibitors or activators of sulfatase enzymes might have an effect on ARSD activity.
If the activity of ARSD is impaired, it can lead to the accumulation of sulfated molecules within lysosomes. This can disrupt normal cellular processes and potentially contribute to lysosomal storage disorders or other related disorders.
Currently, there are no known genetic disorders specifically associated with mutations in the ARSD gene. However, mutations in related sulfatase genes can lead to various lysosomal storage disorders, such as multiple sulfatase deficiency (MSD).
The regulation of ARSD protein activity is not well understood. However, like other lysosomal enzymes, its activity may be influenced by factors such as pH and post-translational modifications.
Customer Reviews (3)
Write a reviewThe impressive performance of the ARSD protein both in ELISA assays and protein electron microscopy structure analysis makes it a highly versatile and recommended choice for scientists across various disciplines.
the ARSD protein finds extensive utility in protein electron microscopy structure analysis.
Its reliability and efficacy in generating high-quality data make it an indispensable tool in the quest for unraveling the mysteries of protein structure and function.
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