ART2
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Official Full Name
ADP-ribosyltransferase 2
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Overview
ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a;posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera,;pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N-;and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was;previously designated ART2. -
Synonyms
ART2; ADP-ribosyltransferase 2; ADP ribosyltransferase 2b; Ag F1; Alloantigen Rt6.2; ART 2; Art2a; Art2b; PtaA; RT ly 2(5); RT6; RT6.1; RT6.2; T cell differentiation marker RT6.1; T cell mono(ADPribosyl)transferase 2; T cell NAD(P)(+)--arginine ADP ribosyltransferase 2; T cell surface protein Rt6.2; alloantigen Rt6.1; ADP-ribosyltransferase 2a; ADP-ribosyltransferase 2b; cell surface alloantigen 6; T-cell surface protein Rt6.1; T-cell surface protein Rt6.2; mono(ADP-ribosyl)transferase 2A; mono(ADP-ribosyl)transfer; LY2; Ag-F; Ly-2;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Rat | ART2-809R | Recombinant Rat ART2 Protein | Mammalian Cell | His |
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| Rat | ART2-465R | Recombinant Rat ART2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | ART2-465R-B | Recombinant Rat ART2 Protein Pre-coupled Magnetic Beads | HEK293 |
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ART2 involved in several pathways and played different roles in them. We selected most pathways ART2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ART2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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ART2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ART2 itself. We selected most functions ART2 had, and list some proteins which have the same functions with ART2. You can find most of the proteins on our site.
| Function | Related Protein |
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ART2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ART2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ART2.
- Q&As
- Reviews
Q&As (10)
Ask a questionThe precise regulation of ART2 gene expression is not well understood, but it may be influenced by various transcription factors and cellular signaling pathways.
ART2 transfers ADP-ribose from NAD+ to specific arginine residues on substrate proteins, modifying their structure and function.
Aside from its enzymatic role in ADP-ribosylation, ART2 does not have any known non-enzymatic functions or specific protein interactions.
Currently, there are no specific therapeutics targeting ART2 for direct modulation. However, research on ADP-ribosylation and its associated pathways may have therapeutic implications in the future.
ART2 is predominantly expressed in the testes, adipose tissue, and certain immune cells like T cells and mast cells.
ART2 primarily ADP-ribosylates arginine residues on various proteins including P2X purinergic receptors and certain immune cell markers such as CD4 and CD8.
The dysregulation of ADP-ribosylation, including ART2 activity, has been implicated in various diseases, such as cancer and inflammatory disorders. However, the specific role of ART2 in these conditions requires further investigation.
ART2 activity is dependent on the presence of NAD+ as a substrate, and it can also be influenced by extracellular ATP levels and extracellular calcium.
Mutations in the ART2 gene have not been directly linked to specific diseases or disorders in humans so far.
Animal models, such as ART2 knockout mice, have been generated to investigate the role of ART2 in vivo, providing insights into its physiological functions.
Customer Reviews (3)
Write a reviewOne notable advantage of the ART2 protein is the outstanding technical support provided by the manufacturer.
Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.
Their expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.
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