AS3MT
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Official Full Name
arsenic (+3 oxidation state) methyltransferase
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Overview
AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 (PubMed 11790780)). -
Synonyms
AS3MT; arsenic (+3 oxidation state) methyltransferase; arsenite methyltransferase; CYT19; methyltransferase cyt19; methylarsonite methyltransferase; S-adenosylmethionine:arsenic (III) methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransfera;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- Involved Pathway
- Protein Function
- Interacting Protein
AS3MT involved in several pathways and played different roles in them. We selected most pathways AS3MT participated on our site, such as Biological oxidations, Metabolism, Methylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with AS3MT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biological oxidations | CYP2J2;CYP2E1;CYP2R1;GSTO2;CYP2C8;PRKRA;AKR1A1;DPEP2;SULT1C2 |
| Metabolism | ACOT9.2;BHMT2;MTF1;LOC100686744;ACOT12;AKR1C4;PPM1L;SLC35D2;KCNJ11 |
| Methylation | TPMT.2;AS3MT;AHCY |
| Phase II conjugation | SLC26A1;UGT1B1;GGTLC1;UGT1B5;UGT1B4;SULT4A1;SLC35B3;UGT1B2;SULT1B1 |
| arsenate detoxification I (glutaredoxin) |
AS3MT has several biochemical functions, for example, S-adenosylmethionine-dependent methyltransferase activity, arsenite methyltransferase activity, methylarsonite methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AS3MT itself. We selected most functions AS3MT had, and list some proteins which have the same functions with AS3MT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| S-adenosylmethionine-dependent methyltransferase activity | RRP8;METTL7A;COQ5;MEPCE;NOP2;PRMT8;SUV39H1;C6orf211;LSM1 |
| arsenite methyltransferase activity | |
| methylarsonite methyltransferase activity | AS3MT;TRMT10C;METTL23;METTL7B;METTL8;FBLL1;METTL21A;PRDM13;DIMT1 |
AS3MT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AS3MT here. Most of them are supplied by our site. Hope this information will be useful for your research of AS3MT.
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- Q&As
- Reviews
Q&As (7)
Ask a questionThe AS3MT protein plays a crucial role in the detoxification and elimination of arsenic from the body, preventing its accumulation and potential toxicity.
The AS3MT protein binds to and methylates inorganic arsenic, facilitating its conversion into organic arsenic metabolites that are easier to eliminate from the body.
The AS3MT protein is primarily associated with the metabolism of arsenic and has not been extensively linked to the metabolism of other substances.
Impairment or dysfunction of the AS3MT protein can lead to reduced arsenic methylation ability, potentially increasing arsenic toxicity in the body.
Yes, alterations in AS3MT gene expression can influence the methylation capacity of arsenic, potentially leading to variations in arsenic toxicity levels.
Yes, genetic variations in the AS3MT gene have been identified and can influence the activity and expression of the AS3MT protein.
The AS3MT protein is associated with arsenic-induced diseases and conditions, such as arsenic poisoning, arsenic-related cancers, and cardiovascular diseases.
Customer Reviews (3)
Write a reviewThe AS3MT Protein has exceeded my expectations by consistently delivering outstanding results and providing exceptional technical support.
In addition to its remarkable quality and exceptional technical support, the AS3MT Protein boasts an impressive range of applications.
Their prompt assistance and willingness to go above and beyond to ensure my success have been immensely valuable.
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