ASAP3
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Official Full Name
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
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Overview
This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. -
Synonyms
ASAP3; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; DDEFL1, development and differentiation enhancing factor like 1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3; centaurin; beta 6; CENTB6; FLJ20199; UPLC1; centaurin,;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | ASAP3-9912H | Recombinant Human ASAP3, GST-tagged | E.coli | GST | 558-903a.a. | |
| Human | ASAP3-2438H | Recombinant Human ASAP3 Protein, GST-tagged | Wheat Germ | GST |
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| Human | ASAP3-450HCL | Recombinant Human ASAP3 cell lysate | N/A |
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| Human | ASAP3-2821H | Recombinant Human ASAP3 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | ASAP3-385H | Recombinant Human ASAP3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Human | ASAP3-2446HF | Recombinant Full Length Human ASAP3 Protein, GST-tagged | In Vitro Cell Free System | GST | 903 amino acids |
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| Human | ASAP3-1261HFL | Recombinant Full Length Human ASAP3 Protein, C-Flag-tagged | Mammalian cells | Flag |
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| Human | ASAP3-385H-B | Recombinant Human ASAP3 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | Asap3-1733M | Recombinant Mouse Asap3 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Zebrafish | ASAP3-3702Z | Recombinant Zebrafish ASAP3 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ASAP3 Related Articles
ASAP3 involved in several pathways and played different roles in them. We selected most pathways ASAP3 participated on our site, such as Endocytosis, Fc gamma R-mediated phagocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASAP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | FAM21C;CBLB;ARPC5;VPS25;RLN1;HSP70;ARF3B;STAMBP;ARRB2A |
| Fc gamma R-mediated phagocytosis | cgr2b;ARF6;HCK;WAS;BIN1;PLA2G4F;CFL2;WASL;WASF3 |
ASAP3 has several biochemical functions, for example, GTPase activator activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASAP3 itself. We selected most functions ASAP3 had, and list some proteins which have the same functions with ASAP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | SRGAP2A;RIN1;TBC1D8B;HTR2B;PTPLAD1;ASAP2B;ARHGDIA;ELMOD1;RGS11 |
| metal ion binding | ZNF771;RIOK2;CPSF3;ZFP382;ASAP1;ZBTB39;RASA3;ZNF573;RBM22 |
| protein binding | JAKMIP2;UBXN1;MED1;ADAM9;MRAP2;ZBTB33;USP14;LNX2;RNF11 |
ASAP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASAP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASAP3.
REL; UBE3A; TFCP2; PDZD3; CRK
- Q&As
- Reviews
Q&As (8)
Ask a questionASAP3 has been found in immune cells, indicating its potential involvement in immune responses, though its exact functions in this context remain to be fully elucidated.
Yes, ASAP3 is involved in cell adhesion processes by regulating the internalization and recycling of adhesion molecules, such as integrins, at the plasma membrane.
Yes, ASAP3 can undergo phosphorylation, acetylation, and ubiquitination, which can affect its stability, activity, and protein-protein interactions.
ASAP3 stimulates the GTP hydrolysis of Arf6, leading to its inactivation and subsequent modulation of vesicle trafficking pathways, including endocytosis and recycling.
ASAP3 has been suggested to play a role in cancer cell invasion and metastasis due to its influence on cell migration, adhesion, and the actin cytoskeleton.
Genetic variations in ASAP3 have been identified, and some studies have linked them to certain diseases or phenotypes, although further research is needed to establish definitive associations.
Yes, ASAP3 can interact with various proteins involved in membrane trafficking, including clathrin, AP1, AP2, and several adaptor proteins.
ASAP3 expression has been observed in neurons, suggesting a potential role in neuronal development, synaptic plasticity, or other neuronal processes, although more investigation is required.
Customer Reviews (3)
Write a reviewThe outstanding level of customer service adds extra reassurance and confidence in using the ASAP3 protein for my scientific investigations.
With the ASAP3 protein and its accompanying technical assistance, I am confident that I can achieve successful outcomes for my research endeavors.
The ASAP3 protein offers numerous advantages in trials and research studies, making it an excellent choice for scientists in need of reliable and high-quality experimental materials.
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