ASB2
-
Official Full Name
ankyrin repeat and SOCS box containing 2
-
Overview
This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
ASB2; ankyrin repeat and SOCS box containing 2; ankyrin repeat and SOCS box protein 2; ASB 2; ankyrin repeat and SOCS box-containing protein 2a; ASB-2; MGC40044;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ASB2-891H | Recombinant Human ASB2 protein, GST-tagged | Wheat Germ | GST |
|
|
| Human | ASB2-40HCL | Recombinant Human ASB2 lysate | HEK293 | N/A |
|
|
| Human | ASB2-1204HF | Recombinant Full Length Human ASB2 Protein, GST-tagged | In Vitro Cell Free System | GST | 587 amino acids |
|
| Mouse | ASB2-2014M | Recombinant Mouse ASB2 Protein | Mammalian Cell | His |
|
|
| Mouse | ASB2-777M | Recombinant Mouse ASB2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
|
|
| Mouse | ASB2-777M-B | Recombinant Mouse ASB2 Protein Pre-coupled Magnetic Beads | HEK293 |
|
||
| Rat | ASB2-817R | Recombinant Rat ASB2 Protein | Mammalian Cell | His |
|
|
| Rat | ASB2-473R | Recombinant Rat ASB2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
|
|
| Rat | ASB2-473R-B | Recombinant Rat ASB2 Protein Pre-coupled Magnetic Beads | HEK293 |
|
- Involved Pathway
- Protein Function
- Interacting Protein
ASB2 involved in several pathways and played different roles in them. We selected most pathways ASB2 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | CRTAM;STIM1B;MAPKAP1;CMTM2A;ACTR1A;SPSB1;CD207;MGC174857;DYNLL2 |
| Antigen processing: Ubiquitination & | RNF182;PJA2;UBA5;RNF14;WWP1;WSB1;STUB1;HUWE1;DZIP3 |
| Proteasome degradation | UBE2L6;UBE2U;LRSAM1;RNF182;UBR1;RNF14;SPSB4;RNF41;ASB6 |
| Class I MHC mediated antigen processing & | MKRN1;LRSAM1;NPEPPS;HUWE1;UBE2U;PJA1;UFL1;ASB6;STUB1 |
| presentation | DTX3L;ASB6;TRIM63;CMTM2A;KLHL20;CTSS;TRAF7;SEC24A;B2ML |
| Immune System | TRIM46;AP1S3A;NCKAP1;OSCAR;CMTM2A;CHST13;TRIM38;CLEC5A;CTS7 |
ASB2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASB2 itself. We selected most functions ASB2 had, and list some proteins which have the same functions with ASB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TNS1;LMO4;DHX16;NPBWR1;CCDC25;HAX1;BEX1;BRE;PTPRE |
ASB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASB2.
HSP90AB1; CUL5; RNF7; SMAD9; ESR2
- Q&As
- Reviews
Q&As (5)
Ask a questionThe ASB2 protein is believed to be involved in cellular processes like protein degradation and the regulation of immune responses, but the specific pathways are still being studied.
The specific substrates targeted by ASB2 for protein degradation have not been fully identified yet.
Currently, there are no known small molecules or drugs that specifically regulate ASB2 activity. Research in this area is ongoing.
Yes, the ASB2 protein has been reported to interact with specific proteins involved in cellular signaling pathways and protein degradation mechanisms.
The potential role of ASB2 gene mutations in disorders is not well-established. Further research is required to understand any disease associations.
Customer Reviews (3)
Write a reviewHighly recommended for its exceptional performance in ELISA, the ASB2 protein is a top contender for researchers involved in protein electron microscopy structure analysis.
Not only does it provide reliable and consistent results due to its high quality and purity, but it also holds significant value in understanding cellular processes and disease mechanisms.
Coupled with the manufacturer's exceptional technical support and commitment to customer satisfaction, researchers can confidently utilize the ASB2 protein in their studies, knowing that they have the necessary resources and assistance to succeed.
Ask a Question for All ASB2 Products
Required fields are marked with *
My Review for All ASB2 Products
Required fields are marked with *
