ASB4
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Official Full Name
ankyrin repeat and SOCS box containing 4
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Overview
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. -
Synonyms
ASB4; ankyrin repeat and SOCS box containing 4; ankyrin repeat and SOCS box protein 4; ASB 4; Ankyrin repeat and SOCS box containing protein 4; ankyrin repeat and SOCS box-containing 4; ASB-4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ASB4-893H | Recombinant Human ASB4 protein, GST-tagged | Wheat Germ | GST | ||
Human | ASB4-8662HCL | Recombinant Human ASB4 293 Cell Lysate | HEK293 | N/A | ||
Human | ASB4-8663HCL | Recombinant Human ASB4 293 Cell Lysate | HEK293 | N/A | ||
Human | ASB4-1296HF | Recombinant Full Length Human ASB4 Protein, GST-tagged | In Vitro Cell Free System | GST | 319 amino acids | |
Mouse | ASB4-2016M | Recombinant Mouse ASB4 Protein | Mammalian Cell | His | ||
Mouse | ASB4-779M | Recombinant Mouse ASB4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ASB4-779M-B | Recombinant Mouse ASB4 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | ASB4-2399Z | Recombinant Zebrafish ASB4 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ASB4 involved in several pathways and played different roles in them. We selected most pathways ASB4 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adaptive Immune System | AP1S1;CTSB;KIF22;RNF138;CLEC2B;GAN;STUB1;KIFAP3;RAET1E |
Antigen processing: Ubiquitination & | RNF25;NPEPPS;TRIM69;TRIM41;FBXO27;ASB18;SPSB4;FBXO3;RNF34 |
Proteasome degradation | KLHL20;RNF19B;UBA5;ATG7;ASB3;ASB6;ASB11;ASB10;ARIH2 |
Class I MHC mediated antigen processing & | UBE2F;FBXO44;CD207;ASB6;UBE2V2;RNF123;FCGR1B;TPP2;GAN |
presentation | TPP2;SEC24A;RNF123;NPEPPS;HECTD3;UBR2;LTN1;STUB1;TRIM11 |
Immune System | PPIAL4A;PAG1;DEFB4B;LILRB2;CD180;TNFSF13B;LAIR2;NCKAP1;BAIAP2 |
ASB4 has several biochemical functions, for example, ubiquitin protein ligase activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASB4 itself. We selected most functions ASB4 had, and list some proteins which have the same functions with ASB4. You can find most of the proteins on our site.
Function | Related Protein |
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ubiquitin protein ligase activity | RNF34;MED24;FBXW11;TRIM72;BTRC;ARIH2;UBE2O;HECTD2;SIAH2L |
ubiquitin protein ligase binding | UCHL1;GLMN;SMAD2;IKBKE;FBXW7;UBE2T;CUL3A;VCL;TCEB2 |
ASB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASB4.
HSP90AB1
- Q&As
- Reviews
Q&As (10)
Ask a questionYes, ASB4 interacts with specific target proteins, recognizing them and facilitating their ubiquitination, leading to their subsequent degradation.
Yes, ASB4 has been observed in both the cytoplasm and the nucleus, suggesting its involvement in diverse cellular compartments and functions.
Yes, ASB4 shows evolutionary conservation, indicating its functional importance across various species.
Yes, ASB4 selectively targets certain proteins for degradation, usually by recognizing specific recognition motifs or interacting with other regulatory factors.
ASB4 can interact with various proteins, including its ubiquitin ligase complex partners or substrate proteins, influencing its activity, localization, or substrate specificity.
Currently, there are no known diseases or disorders directly linked to ASB4 dysfunction. However, its dysregulation may potentially contribute to various pathological conditions, requiring further investigation.
ASB4-mediated protein degradation can impact cellular processes such as gene expression, signal transduction, cell proliferation, and differentiation.
Yes, ASB4 has been implicated in skeletal muscle development, differentiation, and regeneration processes based on experimental evidence and studies in animal models.
Presently, there are no specific drugs targeting ASB4. However, understanding its role and identifying potential modulators may open avenues for therapeutic interventions in the future.
Yes, ASB4 expression can be regulated by external signals, including hormones, cytokines, growth factors, and cellular stress.
Customer Reviews (3)
Write a reviewThe manufacturer's outstanding technical support serves as a valuable resource, providing prompt and knowledgeable assistance whenever I encounter difficulties or require guidance.
the ASB4 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications.
Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways.
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