ASCL1A
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Official Full Name
achaete-scute complex-like 1a (Drosophila)
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Synonyms
ASCL1A; achaete-scute complex-like 1a (Drosophila); achaete-scute homolog 1a; Achaete scute homolog 1a; ash; ash1a; asha; pia; Pituitary absent protein; Zash 1a; pituitary absent; pituitary-absent protein; zasha; zash1a; Zash-1a; id:ibd5085; im:7138587; si:dkey-264k15.2;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Zebrafish | ASCL1A-8820Z | Recombinant Zebrafish ASCL1A | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ASCL1A Related Articles
ASCL1A involved in several pathways and played different roles in them. We selected most pathways ASCL1A participated on our site, such as Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASCL1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Delta-Notch Signaling Pathway | TUBB3;CNTN1B;JAG1;RING1;NOV;HES6;MAGEA1;ASCL1;JAG2 |
ASCL1A has several biochemical functions, for example, DNA binding, protein dimerization activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASCL1A itself. We selected most functions ASCL1A had, and list some proteins which have the same functions with ASCL1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | POLR1A;POLR3B;RX1;ZFP287;DEK;SP140L;EPAS1B;NCOR2;HIST1H3H |
| protein dimerization activity | HIF1AB;NEUROG1;HER5;MYCB;FAP;CLOCK;PRKRIR;STK4;ASCL2 |
| sequence-specific DNA binding | FOXL1;EMX3;AHR;DMRT2B;ESRRGA;DMBX1;TCF3A;MNX2B;LONP1 |
| transcription factor activity, transcription factor binding | PER1;CRY1;LDB1A;TRP63;ASCL1A;NEUROG1;PER2;ASCL1;LDB2B |
ASCL1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASCL1A here. Most of them are supplied by our site. Hope this information will be useful for your research of ASCL1A.
- Q&As
- Reviews
Q&As (7)
Ask a questionASCL1A dysregulation is associated with neurodevelopmental disorders, such as autism spectrum disorders and intellectual disability, where mutations or altered expression levels have been observed.
ASCL1A acts as a transcription factor that directs neural progenitor cells to differentiate into neurons during neurogenesis, playing a key role in the formation of the nervous system.
Yes, ASCL1A is crucial for the development of specific neuronal subtypes, including subtypes in the cerebral cortex, olfactory bulb, and autonomic ganglia.
ASCL1A, in combination with other transcription factors, has been shown to induce the reprogramming of somatic cells into neurons in vitro, demonstrating its potential for cell fate alteration.
ASCL1A's role in adult neurogenesis is less well-understood, as it is primarily active during embryonic development, but some studies suggest its presence in specific adult brain regions.
ASCL1A is being explored as a potential therapeutic target in neurodevelopmental disorders. Modulating its activity may hold promise for developing therapeutic strategies.
ASCL1A interacts with various proteins involved in neurodevelopment, including NEUROD1, TCF3, TLE1, and HDAC1.
Customer Reviews (3)
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Their in-depth understanding of the protein's characteristics, applications, and potential limitations allows for valuable insights and recommendations, ensuring the success of my experiments.
Its purity, integrity, and consistency ensure reliable and reproducible results, which are essential for meaningful scientific discoveries.
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