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ASH1L

Official Full Name

ash1 (absent, small, or homeotic)-like
Overview

This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions.
Synonyms

ASH1L; ash1 (absent, small, or homeotic)-like (Drosophila); histone-lysine N-methyltransferase ASH1L; ASH1; ASH1L1; huASH1; KMT2H; ASH1-like protein; lysine N-methyltransferase 2H; absent small and homeotic disks protein 1 homolog; probable histone-lysine;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|Flag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ASH1L-30H	Recombinant Human ATAD2, His&FLAG-tagged	E.coli	His/Flag		Inquiry
Human	ASH1L-905H	Recombinant Human ASH1L protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ASH1L-47H	Recombinant Human ASH1L protein, GST-tagged	E.coli	GST	2022-2302	Inquiry
Human	ASH1L-48H	Recombinant Human ASH1L protein, His-tagged	E.coli	His		Inquiry
Human	ASH1L-49H	Recombinant Human ASH1L protein, GST-tagged	E.coli	GST	2428-2559	Inquiry
Human	ASH1L-50H	Recombinant Human ASH1L protein, His-tagged	E.coli	His	2428-2559	Inquiry
Mouse	ASH1L-2031M	Recombinant Mouse ASH1L Protein	Mammalian Cell	His		Inquiry
Mouse	ASH1L-790M-B	Recombinant Mouse ASH1L Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	ASH1L-790M	Recombinant Mouse ASH1L Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein

ASH1L involved in several pathways and played different roles in them. We selected most pathways ASH1L participated on our site, such as Lysine degradation, Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASH1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Lysine degradation	AADAT;SUV39H2;ALDH1B1;PLOD2;ACAT1;HADHA;HYKK.2;ALDH2.2;SETD8B
Tight junction	AKT2;MYH3;CLDN3;PPP2R1B;OCLNB;MYLPF;RHOA;NRAS;MYH6

ASH1L has several biochemical functions, for example, DNA binding, chromatin binding, histone methyltransferase activity (H3-K36 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by ASH1L itself. We selected most functions ASH1L had, and list some proteins which have the same functions with ASH1L. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	PHF5A;ZFP628;SP140;EGR3;DUX3;HIST1H4F;ZNF556;ZFP641;HOXA1A
chromatin binding	RBPJ;MKRN1;MCMBP;ESR1;GLI3;RING1;WAC;TRIM37;NIPBL
histone methyltransferase activity (H3-K36 specific)	ASH1L;SETD2;SMYD2;NSD1;SETMAR;SMYD2B;SMYD2A;SETD3
histone methyltransferase activity (H3-K4 specific)	ASH1L;WBP7;SETD3;MLL5;WDR82;SETMAR;KMT2E;SMYD1B;KMT2A
zinc ion binding	DBF4;CAPNS2;MARCH4;LIN28A;ZNF207;CPA2;ADAM33;SCEL;NR1I3

ASH1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASH1L here. Most of them are supplied by our site. Hope this information will be useful for your research of ASH1L.

SMAD7; mtlA