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ASH2L

Official Full Name

ash2 (absent, small, or homeotic)-like
Overview

Set1/Ash2 histone methyltransferase complex subunit ASH2 is an enzyme that in humans is encoded by the ASH2L gene.
Synonyms

ASH2L; ash2 (absent, small, or homeotic)-like (Drosophila); ash2 (absent, small, or homeotic, Drosophila, homolog) like , ASH2L1; set1/Ash2 histone methyltransferase complex subunit ASH2; ASH2; ASH2L2; Bre2; ASH2-like protein; ASH2L1;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Mouse
Zebrafish

Source

E. coli
E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His|SUMO
Myc
DDK
N/A
SUMO

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ASH2L-009H	Active Recombinant Human ASH2L Protein, SUMO-tagged	E.coli	SUMO	96-628	Inquiry
Human	ASH2L-9933H	Recombinant Human ASH2L, GST-tagged	E.coli	GST	C-term-300a.a.	$319 / 25ug
Human	ASH2L-906H	Recombinant Human ASH2L protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ASH2L-8652HCL	Recombinant Human ASH2L 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ASH2L-1087HF	Recombinant Full Length Human ASH2L Protein, GST-tagged	In Vitro Cell Free System	GST	534 amino acids	Inquiry
Human	ASH2L-1146H	Recombinant Human ASH2L Protein (1-534 aa), His-SUMO-tagged	E.coli	His/SUMO	1-534 aa	Inquiry
Human	ASH2L-159H	Recombinant Human ASH2L Protein, SUMO-tagged	E. coli	SUMO		Inquiry
Mouse	Ash2l-1743M	Recombinant Mouse Ash2l Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	ASH2L-6103Z	Recombinant Zebrafish ASH2L	Mammalian Cell	His		Inquiry
Chicken	ASH2L-3046C	Recombinant Chicken ASH2L	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

ASH2L involved in several pathways and played different roles in them. We selected most pathways ASH2L participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Deactivation of the beta-catenin transactivating complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASH2L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chromatin modifying enzymes	PADI6;ARID1A;DNMT3A;DMAP1;SMARCA2;MBD3A;CHD4;EED;MSL1A
Chromatin organization	PHF8;CCDC101;MBD3B;KDM6AL;KDM4A;ING5B;ELP4;RBBP4;ING3
Deactivation of the beta-catenin transactivating complex	BCL9;TLE3;SOX13;C;SOX4A;CTBP1;TLE2;SRY;SOX9A
Formation of the beta-catenin:TCF transactivating complex	H3F3D;TLE3B;TLE1;ASH2L;TLE2;CDC73;BCL9L;TLE4;PYGO1
PKMTs methylate histone lysines	SMYD3;AEBP2;DPY30;SETD3;SMYD2;SMYD2A;ASH2L;SUZ12A;SUZ12B
Signal Transduction	SAGB;RTKN;OPN1SW1;RSPO2;LGR4;TAX1BP3;MOB1BA;NMB;NEDD8
Signaling by Wnt	C;WNT8-2;TNKS;RYK;BCL9;FMNL3;SOX6;LGR4;CBY1
TCF dependent signaling in response to WNT	RYK;SOX4A;RNF43;TNKS;TNKS2;CDC73;SOX4B;LEO1;SOX13

ASH2L has several biochemical functions, for example, DNA binding, beta-catenin binding, euchromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASH2L itself. We selected most functions ASH2L had, and list some proteins which have the same functions with ASH2L. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ZFP526;ZNF280C;DMRTA2;FOXC1A;MBD1B;Rhox5;HIST1H2BF;ZNF324;ZFP260
beta-catenin binding	DACT2;ESR1;AXIN1;SOX9;FAM123B;TCF7;GSK3B;PROP1;GRIP1
euchromatin binding	ASH2L;CTNNB1
contributes_to histone methyltransferase activity (H3-K4 specific)	ASH2L;CXXC1;DPY30;RBBP5;DYDC1;DYDC2
metal ion binding	ALOX5B.3;ZFP526;CYB5B;NR1H5;BTR06;RHOV;ZBED3;PATZ1;LIG4
protein binding	CASP1;FRMD4B;THBD;NLRP1;PDE4DIP;ATP6AP2;PHF10;PAGE5;SOD1
transcription regulatory region DNA binding	FOXA2;TFE3;SOX17;STAT3;TAF9;TP63;HNF4A;GRHL2B;FOXA3

ASH2L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASH2L here. Most of them are supplied by our site. Hope this information will be useful for your research of ASH2L.

RBBP5; DPY30