asph
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  • Official Full Name
  • aspartate beta-hydroxylase
  • Background
  • This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis.
  • Synonyms
  • ASPH; aspartate beta-hydroxylase; aspartyl/asparaginyl beta-hydroxylase; BAH; CASQ2BP1; HAAH; humbug; JCTN; junctate; junctin; ASP beta hydroxylase; Aspartyl/asparaginyl beta hydroxylase; Peptide aspartate beta dioxygenase; A beta H-J-J; cardiac junctin; ASP beta-hydroxylase; peptide-aspartate beta-dioxygenase; aspartyl/asparaginyl-beta-hydroxylase; AAH
Cat.#:ASPH-396HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ASPH Protein, His-tagged
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Cat.#:ASPH-1940HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Aspartate beta-hydroxylase, His-tagged
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Cat.#:ASPH-27059THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ASPH, His-tagged
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Cat.#:ASPH-917HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ASPH protein, GST-tagged
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Cat.#:ASPH-9940HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ASPH, GST-tagged
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Cat.#:ASPH-8165ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ASPH
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Cat.#:ASPH-8643HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ASPH 293 Cell Lysate
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Cat.#:ASPH-8644HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ASPH 293 Cell Lysate
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Cat.#:ASPH-8645HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ASPH 293 Cell Lysate
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Involved Pathway

ASPH involved in several pathways and played different roles in them. We selected most pathways ASPH participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASPH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ion channel transport
SLC9A10; ANO1; SRI; BEST3; ATP10A; ANO5B; ATP2B3A; TRPV3; ATP6V1G3; CLCN7
Stimuli-sensing channels
ANO7; SLC9A10; FKBP1B; TPCN1; TRPM4C; SRI; ASIC1A; TTYH3B; ANO10A; OSTM1
Transmembrane transport of small molecules
FXYD6; AQP11; SLC20A2; OSTM1; ATP1A1A.2; SLC13A3; SGK2; SLC38A3; SLC39A10; SLC35B3

Protein Function

ASPH has several biochemical functions, for example, calcium ion binding, electron carrier activity, ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASPH itself. We selected most functions ASPH had, and list some proteins which have the same functions with ASPH. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein DMP1; EFHC2; KIAA0494; ANXA3; C1R; PPP3CA; EFHC1; SYT15; SLIT1B; ATP2A2
Function electron carrier activity
Related Protein ACADL; NDUFS1; AKR1B1; CYBA; ACOX3; AKR7A2; POR; DERL3; TSTA3; UGDH
Function ion channel binding
Related Protein CIB1; SCN3B; KCNC1; ACTN4; PACS1A; KCNE2; SLC8A1; GPD1L; CHERP; LRRK2
Function peptide-aspartate beta-dioxygenase activity
Related Protein ASPH
Function protein binding
Related Protein KIAA0408; IWS1; GORASP2; PTPN22; PSMA7; CCDC123; TTC23L; NOV; C2orf29; MUC2
Function structural constituent of muscle
Related Protein SORBS2; TTN; TCAP; PLEC; MYL9; ASPH; TPM4; MYBPH; MYL3; MYL5
Function structural molecule activity
Related Protein KRT86; CLDN3; CLDN10; KRTAP3-1; KRT85; CLDN5A; JUP; CLDN15LB; SPRR3; CLDN22

Interacting Protein

ASPH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASPH here. Most of them are supplied by our site. Hope this information will be useful for your research of ASPH.
ASNA1; HTT; SQSTM1; PDGFRL; ssrna_ug; IQCB1; P; MAP1LC3A