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ASPN

  • Official Full Name

    asporin

  • Overview

    This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
  • Synonyms

    ASPN; asporin; OS3; PLAP1; PLAP-1; SLRR1C; asporin proteoglycan; asporin (LRR class 1); small leucine-rich protein 1C; periodontal ligament associated protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His|GST
  • His|SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ASPN-919H Recombinant Human ASPN protein, GST-tagged Wheat Germ GST
Human ASPN-138HCL Recombinant Human ASPN cell lysate N/A
Human ASPN-2003H Recombinant Human ASPN Protein (33-380 aa), His-SUMO-tagged E.coli His/SUMO 33-380 aa
Human ASPN-1211HF Recombinant Full Length Human ASPN Protein, GST-tagged In Vitro Cell Free System GST 384 amino acids
Human ASPN-256H Recombinant Human ASPN Protein, His-tagged E.coli N-His Phe57-Met371
Mouse Aspn-255M Recombinant Mouse Aspn Protein, His-tagged E.coli N-His Lys16-Lys373
Mouse Aspn-551M Recombinant Mouse Aspn Protein, His/GST-tagged E.coli His/GST Lys16~Lys373
Zebrafish ASPN-9234Z Recombinant Zebrafish ASPN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ASPN Related Articles
  • ASPN Related Research Area

ASPN involved in several pathways and played different roles in them. We selected most pathways ASPN participated on our site, such as ECM proteoglycans, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASPN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ECM proteoglycansMATN3;COL9A1;ACAN;PTPRS;ITGB3A;ASPN;SPARC;FMOD;BGNA
Extracellular matrix organizationADAM8;ADAMTS8;COL8A2;COL9A3;CAPNS1;PRP;COL6A3;KLK7;TPSAB1

ASPN has several biochemical functions, for example, calcium ion binding, collagen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASPN itself. We selected most functions ASPN had, and list some proteins which have the same functions with ASPN. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingMYLPFA;CALML4A;NOTCH2NL;ANXA9;ANXA13L;JAG2B;S100A1;PCDH2AB8;EMR1
collagen bindingITGA10;ABI3BP;NID1;ITGA3;CTSL1;SERPINH1B;Itga10&Itgb1;ACHE;PDGFA

ASPN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASPN here. Most of them are supplied by our site. Hope this information will be useful for your research of ASPN.

Heo, S; Yang, JW; et al. Mass spectrometric characterization of recombinant rat 5-hydroxytryptamine receptor 1A (5-HT1AR) expressed in tsA201 human embryonic kidney cells. PROTEOMICS 12:3338-3342(2012).
Dechavanne, C; Guillonneau, F; et al. Mass Spectrometry Detection of G3m and IGHG3 Alleles and Follow-Up of Differential Mother and Neonate IgG3. PLOS ONE 7:-(2012).
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