ASS1
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Official Full Name
argininosuccinate synthase 1
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Overview
The protein encoded by this gene catalyzes the penultimate step of the arginine biosynthetic pathway. There are;approximately 10 to 14 copies of this gene including the pseudogenes scattered across the human genome, among which;the one located on chromosome 9 appears to be the only functional gene for argininosuccinate synthetase. Mutations in;the chromosome 9 copy of this gene cause citrullinemia. Two transcript variants encoding the same protein have been;found for this gene. -
Synonyms
ASS1; argininosuccinate synthase 1; argininosuccinate synthase; Argininosuccinate synthetase 1; ASS; Ass-1; ASSA; ASSY_HUMAN; Citrulline aspartate ligase; Citrulline--aspartate ligase; CTLN1; citrullinemia;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- C
- Myc
- DDK
- Flag
- His
- His (Fc)
- Avi
- MYC
- N/A
- N
- 6×His
- Involved Pathway
- Protein Function
- Interacting Protein
ASS1 involved in several pathways and played different roles in them. We selected most pathways ASS1 participated on our site, such as Arginine biosynthesis, Alanine, aspartate and glutamate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arginine biosynthesis | GLULB;NOS2;GOT2B;ARG1;GLUL;ASL;NOS2B;ybaS;GLUD2 |
| Alanine, aspartate and glutamate metabolism | GLUL;GLULB;GOT2B;GAD2;ADSSL1;GAD1;GLULA;AGXT;ybaS |
| Metabolic pathways | SPTLC2;PLCB1;CECR1A;PLA2G2E;PPT2;GART;SCP2A;TWISTNB;CKMT2 |
| Biosynthesis of amino acids | GPT;PCXB;AADAT;MTR;GLULA;ASL2;ENO1B;pykF;SHMT1 |
ASS1 has several biochemical functions, for example, ATP binding, amino acid binding, argininosuccinate synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ASS1 itself. We selected most functions ASS1 had, and list some proteins which have the same functions with ASS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | DDX3;CAMK2D2;AURKC;EIF4A1;PKDCC;PTK2AA;EIF4A1A;PRKACA;RPS6KA6 |
| amino acid binding | TAT;TPH1B;KARS;DDC;DDAH2;TPH1A;GOT2;TH;TPH1 |
| argininosuccinate synthase activity | |
| identical protein binding | CIDEB;MIEF1;PRDX1;PARP1;ZBTB16;LRRK1;SERPINA1E;CTSC;RIPK3 |
| poly(A) RNA binding | TNPO1;MYH9;NOVA2;MRPL14;STRBP;SRSF7;HNRNPA1;YWHAZ;PURG |
| protein binding | SLC25A23;LASP1;FANCB;PPP2R2A;ODAM;ABLIM1;MS4A3;CDKN1C;STK38 |
| toxic substance binding | H2-AB1;CHRNA7;DSG1;A4GALT;PHAX;Alb;AZU1;ASS1;NEFH |
ASS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASS1.
YWHAZ; Bles03; JAK2; MT2A; ARAF; PTPN1; MLH1; TERF1; CDR2; TERF2; yitU; ASCC2; AKTIP
- Q&As
- Reviews
Q&As (7)
Ask a questionASS1 regulates cell growth by controlling the availability of arginine, a key amino acid for cell proliferation.
ASS1 deficiency leads to urea cycle disorders, causing hyperammonemia and metabolic imbalances.
ASS1 affects amino acid metabolism, playing a critical role in cellular health and function.
ASS1 is essential in the urea cycle, converting nitrogen waste into urea for excretion and maintaining nitrogen balance.
Variations in ASS1 activity can impact cardiovascular health, influencing nitric oxide production and vascular function.
ASS1 is involved in arginine synthesis, impacting nitric oxide levels and vascular function.
ASS1 influences how the body metabolizes high-protein diets, affecting metabolic responses and health.
Customer Reviews (3)
Write a reviewCritical expertise in protein engineering, a trusted research resource.
Dependable peptide synthesis, accelerates our peptide-based projects effectively.
Efficient protein purification, cost-effective and dependable.
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