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ASXL1

Official Full Name

additional sex combs like 1 (Drosophila)
Overview

This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.
Synonyms

ASXL1; additional sex combs like 1 (Drosophila); putative Polycomb group protein ASXL1; KIAA0978; Additional sex combs like protein 1; OTTHUMP00000030592; OTTHUMP00000030593; OTTHUMP00000245206; additional sex combs-like protein 1; MDS; BOPS;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
Myc|DDK
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ASXL1-9951H	Recombinant Human ASXL1, His-tagged	E.coli	His	1-84a.a.	$319 / 25ug
Human	ASXL1-926H	Recombinant Human ASXL1 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ASXL1-2926H	Recombinant Human ASXL1 Protein, GST-tagged	E.coli	GST		Inquiry
Human	ASXL1-1409HF	Recombinant Full Length Human ASXL1 Protein, GST-tagged	In Vitro Cell Free System	GST	84 amino acids	Inquiry
Human	ASXL1-2928H	Recombinant Human ASXL1 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	ASXL1-0414H	Recombinant Human ASXL1 Protein (Lys1477-Arg1541), N-GST-tagged	E.coli	N-GST	Lys1477-Arg1541	Inquiry
Mouse	ASXL1-2052M	Recombinant Mouse ASXL1 Protein	Mammalian Cell	His		Inquiry
Mouse	ASXL1-805M	Recombinant Mouse ASXL1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Asxl1-1755M	Recombinant Mouse Asxl1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	ASXL1-805M-B	Recombinant Mouse ASXL1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

ASXL1 involved in several pathways and played different roles in them. We selected most pathways ASXL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ASXL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

ASXL1 has several biochemical functions, for example, DNA binding, metal ion binding, peroxisome proliferator activated receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASXL1 itself. We selected most functions ASXL1 had, and list some proteins which have the same functions with ASXL1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ZSCAN2;PIAS2;ZNF189;RORA;ZNF41;KRBA2;HOXB1B;DLX2B;NRL
metal ion binding	ZNF831;Itgam&Itgb2;ATP1A4;PPP3CB;ACSM1;IMPDH1A;ZNF777;ZFP93;CDK15
peroxisome proliferator activated receptor binding	MED1;ASXL2;PRMT2;NFATC4;EP300;PPARGC1A;IKBKG;ASXL1;HMGA1-RS1
protein binding	CHEK2;ZFP161;RND1;RELL2;YTHDF3;GOLGA8G;SARM1;MAP3K14;ARHGAP5
retinoic acid receptor binding	PRAMEF2;PRAMEF1;ACTN4;HMGA1-RS1;PRAME;PRAMEF10;AASS;HMGA1;CTBP2
transcription coactivator activity	ING4;TADA3;MMS19;PRPF6;RARA;TRIP4;MYCBP;LPIN1;RB1
transcription corepressor activity	MTA1;TBL1Y;SFMBT1;TBL1XR1B;PBXIP1;NANOG;ZBTB32;DMAP1;DDIT3

ASXL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASXL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASXL1.

BAP1; EZH2; Bap1; ESR1; Rxra; THRB; AKT1