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ATF4

  • Official Full Name

    activating transcription factor 4 (tax-responsive enhancer element B67)

  • Overview

    This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding;protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated;and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to;a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding;proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in;protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding;domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the;X chromosome at q28 in a region containing a large inverted duplication.
  • Synonyms

    ATF4; activating transcription factor 4 (tax-responsive enhancer element B67); TXREB; cyclic AMP-dependent transcription factor ATF-4; CREB 2; TAXREB67; DNA-binding protein TAXREB67; cAMP response element-binding protein 2; cAMP-dependent transcription fa;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|CaM
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATF4-3596H Recombinant Human ATF4, His Cam-tagged E.coli His/CaM
Human ATF4-27048TH Recombinant Human ATF4, His-tagged E.coli His
Human ATF4-27047TH Recombinant Human ATF4, His-tagged E.coli His 351 amino acids
Human ATF4-939H Recombinant Human ATF4 protein, GST-tagged Wheat Germ GST
Human ATF4-8630HCL Recombinant Human ATF4 293 Cell Lysate HEK293 N/A
Human ATF4-1074HF Recombinant Full Length Human ATF4 Protein, GST-tagged In Vitro Cell Free System GST 351 amino acids
Human ATF4-0291H Recombinant Human ATF4 Protein (Met1-Pro351), N-His-tagged E.coli N-His Met1-Pro351
Human ATF4-217HFL Recombinant Full Length Human ATF4 Protein, N-His-tagged E.coli His
Mouse Atf4-6891M Recombinant Mouse Atf4 protein, His & T7-tagged E.coli His/T7 Val126~Thr291 (Accession # Q06507)
Mouse ATF4-2067M Recombinant Mouse ATF4 Protein Mammalian Cell His
Mouse ATF4-813M Recombinant Mouse ATF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ATF4-813M-B Recombinant Mouse ATF4 Protein Pre-coupled Magnetic Beads HEK293
Rat Atf4-6892R Recombinant Rat Atf4 protein, His & T7-tagged E.coli His/T7 Val125~Tyr329 (Accession # Q9ES19)
Rat Atf4-183R Recombinant Rat Atf4 protein, His&Myc-tagged E.coli His&Myc 1-347aa
Rat Atf4-184R Recombinant Rat Atf4 protein, His&Myc-tagged E.coli His&Myc 1-347aa
Rhesus Macaque ATF4-438R Recombinant Rhesus monkey ATF4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ATF4-267R Recombinant Rhesus Macaque ATF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ATF4-267R-B Recombinant Rhesus Macaque ATF4 Protein Pre-coupled Magnetic Beads HEK293
Chicken ATF4-6443C Recombinant Chicken ATF4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ATF4 Related Articles
  • ATF4 Related Research Area

ATF4 involved in several pathways and played different roles in them. We selected most pathways ATF4 participated on our site, such as MAPK signaling pathway, cGMP-PKG signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayMAPKAPK5;CACNG1;NR4A1;CACNA1G;PRKCB;HSPA6;GNA12A;CACNA1C;FGF10
cGMP-PKG signaling pathwayPDE2A;IRS1;ATP2A3;PPP1R12A;ATP2A1;GTF2IRD1;VDAC2;PRKCE;ATF4
Protein processing in endoplasmic reticulumSEC61G;UBE2D2L;MAPK10;TUSC3;EIF2AK3;PKZ;SEC31A;SEC24B;UBE2G1B
PIK-Akt signaling pathwayTP53;CREB3L3;FOXO3;GYS1;PTEN;ITGA10;IL7;MLST8;LPAR4
Adrenergic signaling in cardiomyocytesPPP2R3A;ATP1A4;ADCY8;VMHC;GNAQ;PIK3R2;ATP1B2;ATP1A3B;CALM4
TNF signaling pathwayMAPK3;TRAF3;TNFRSF1A;PIK3CB;MAP3K5;Ccl12;BCL3;NFKBIA;MAP3K7
Long-term potentiationGRIA2;GRIN1;CALM1;RAF1;GRIN2A;PRKACG;CALM4;ITPR1;PPP1CA
Neurotrophin signaling pathwayAKT2;NFKBIB;CAMK2B;MAPK13;TP73;MAP3K3;MAPK3;NGFR;IKBKB
Cholinergic synapseGNAQ;PRKCG;GNG5;PRKACA;ITPR3;CREB3;GNGT2;GNG7;GNG13
Dopaminergic synapsePPP2CB;GSK3A;CREB5;GRIA4;CREB3L1;PPP2R5D;CREB3L4;GNG3;SCN1A
Insulin secretionTRPM4;PRKACB;GNAQ;KCNMB2;ATP1B4;PRKACG;RAPGEF4;SLC2A2;CREB3L1
GnRH signaling pathwayATF4B1;CAMK2B;GNA11A;CALM2;FSHB;CAMK2D;CAMK2A;PLA2G4A;MAPK7
Estrogen signaling pathwayKCNJ3;CREB5;CREB3L3;CALML3;HSPA1L;GNAO1;PLCB1;ESR1;MMP9
Thyroid hormone synthesisTSHB;Adcy4;GPX7;CREB3L1;DUOXA2;PLCB4;ATP1B3;SLC26A4;PRKCB
Aldosterone synthesis and secretionPRKCE;AGTR1B;NETO2;CALML3;CAMK2D;ORAI1;NPR1;ADCY3;CACNA1G
Non-alcoholic fatty liver disease (NAFLD)NFKB1;MAPK9;UQCRC1;PKLR;NDUFS6;SOCS3;COX7A2;NDUFAB1;UQCRFS1
Cocaine addictionGRIN3A;GNAI1;GRIN2C;CDK5;CDK5R1;GNAI2;PRKACA;SLC18A2;GPSM1
AlcoholismHIST1H2BN;GNAO1;GRIN3B;NTRK2;GM14477;HIST1H2AI;HIST1H2BF;GM14483;SLC18A2
Hepatitis BCREB3L1;IFNA5;CCNE1;PRKCA;EGR2;IFNA10;CREB3L2;STAT5A;PIK3R5
HTLV-I infectionTGFB1;H2-AB1;ITGB2;HLA-DOA;HLA-F;SLC25A4;HLA-DRA;KAT2A;CDC27
Viral carcinogenesisSCRIB;H2-Q10;CCND2;YWHAE;LYN;STAT5B;HDAC7A;YWHAB;HIST1H4A
Prostate cancerNRAS;NFKB1;MAP2K2;HSP90AB1;NKX3-1;PDPK1;INS2;MAPK1;IKBKB

ATF4 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATF4 itself. We selected most functions ATF4 had, and list some proteins which have the same functions with ATF4. You can find most of the proteins on our site.

Function Related Protein
DNA bindingUBN2;GM6026;MYCB;RAD51C;REV3L;LHX1A;FAM60AL;ZBTB1;HIST3H3
RNA polymerase II core promoter proximal region sequence-specific DNA bindingGZF1;GATA4;RBPJB;ZNF217;BATF2;JUNBA;ZNF257;MEF2B;OVOL1
RNA polymerase II regulatory region sequence-specific DNA bindingCREB3L3;PKNOX2;MYOD1;TBX20;H2AFY;ZFP39;ONECUT3;ZGLP1;ESX1
RNA polymerase II transcription factor activity, sequence-specific DNA bindingJUNBA;JUNBB;FOXO1B;SPIC;SP3A;BMPR1A;MITFB;RUNX3;HIF1AL
RNA polymerase II transcription factor bindingGATA2A;TEAD3;GATA5;T;TBX3;GSK3B;TBX6;TOX2;GATA2
core promoter sequence-specific DNA bindingZFP932;H2AFY;NFYA;SOHLH2;SOHLH1;NR1D1;PDX1;MYOCD;REST
leucine zipper domain bindingERC1;ATF4;CRX;KCNA3;PMF1;DDIT3;AATF;NRL;DAPK3
protein C-terminus bindingYWHAQ;SLC9A3R2;KPNA3;SNTG1;PFKM;ERCC4;PPP2CA;TOP2A;PEX16
protein bindingARPC2;PDIK1L;WBP2;HIST1H4G;TBC1D23;AP3S1;AP1G2;ARHGEF2;GMPPA
protein heterodimerization activitySMC1A;SLC51B;SUPT3H;RALGAPA1;BAXA;TCF3B;RAF1;NFYBA;SCUBE1
sequence-specific DNA bindingFOXO3A;ARX;ZKSCAN14;BCL11B;CEBPG;DLX2B;LEF1;FOXI1;PRRXL1
transcription factor activity, RNA polymerase II transcription factor bindingTWIST2;MAMSTR;ATF2;SMAD4;LHX2;THRAA;HIF1A;NACC2;SRF
transcription factor activity, sequence-specific DNA bindingUBN2B;ZFP354B;ZSCAN23;TSC22D3;AHR;SCMH1;ZNF550;CREB3L3L;MYCH
transcription regulatory region DNA bindingFOXH1;CTCFL;CREB3L1;IKZF3;GABPB1;ARRB1;ZBTB14;KDM1A;BCOR
contributes_to transcription regulatory region DNA bindingNR1H3;HDAC5;HAND1;NFYA;NFYC;TCF3;TAF1;TCF12;HDAC4
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingMEOX2;HNRNPK;ETV2;ZIC3;GLIS2;PLAG1;MAFA;TBX20;NOBOX

ATF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATF4.

BTRC; TRIB3; CREBZF; CEBPG

Rubovitch, V; Barak, S; et al. The Neuroprotective Effect of Salubrinal in a Mouse Model of Traumatic Brain Injury. NEUROMOLECULAR MEDICINE 17:58-70(2015).
Hussain, H; Maldonado-Agurto, R; et al. The endoplasmic reticulum and unfolded protein response in the control of mammalian recombinant protein production. BIOTECHNOLOGY LETTERS 36:1581-1593(2014).
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