ATRX
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Official Full Name
alpha thalassemia/mental retardation syndrome X-linked
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Overview
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. -
Synonyms
ATRX; alpha thalassemia/mental retardation syndrome X-linked; alpha thalassemia/mental retardation syndrome X linked (RAD54 (S. cerevisiae) homolog) , JMS, Juberg Marsidi syndrome , RAD54; transcriptional regulator ATRX; RAD54 homolog (S. cerevisiae); XH;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- SUMO
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | ATRX-1028H | Recombinant Human ATRX protein, GST-tagged | Wheat Germ | GST |
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| Human | ATRX-150H | Recombinant Human ATRX protein, GST-tagged | Wheat Germ | GST | 1 a.a. - 90 a.a. |
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| Human | ATRX-10065H | Recombinant Human ATRX, GST-tagged | E.coli | GST | 1-87a.a. | |
| Human | ATRX-10066H | Recombinant Human ATRX protein, His-tagged | E.coli | His | 1-87aa | |
| Human | ATRX-150HCL | Recombinant Human ATRX cell lysate | N/A |
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| Human | aTRX-1288H | Recombinant Human aTRX protein, His-tagged | E.coli | His | Trp221~Ser342 |
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| Human | ATRX-1535HF | Recombinant Full Length Human ATRX Protein, GST-tagged | In Vitro Cell Free System | GST | 90 amino acids |
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| Human | ATRX-13HFL | Recombinant Full Length Human ATRX Protein, C-His-tagged | E.coli | N-His |
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| Human | ATRX-1289H | Recombinant Human ATRX protein, His-SUMO-tagged | E.coli | His-SUMO | Trp221~Ser342 |
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| Mouse | ATRX-2191M | Recombinant Mouse ATRX Protein | Mammalian Cell | His |
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| Mouse | ATRX-898M | Recombinant Mouse ATRX Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | ATRX-898M-B | Recombinant Mouse ATRX Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | ATRX-10922Z | Recombinant Zebrafish ATRX | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ATRX Related Articles
- ATRX Related Research Area
ATRX involved in several pathways and played different roles in them. We selected most pathways ATRX participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ATRX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
ATRX has several biochemical functions, for example, ATP binding, DNA binding, DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATRX itself. We selected most functions ATRX had, and list some proteins which have the same functions with ATRX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | TSSK1;TAP1;CHKA;ATAD1B;RAD51C;GSK3AB;STRC;PRPF4B;Atp8a2 |
| DNA binding | DDX3X;EVE1;TBPL2;HOMEZA;ZFP422;ZFP579;ARID1AA;ZFML;MIER1 |
| DNA helicase activity | MCM2;MCM5;WRN;MCM6L;RECQL;RUVBL2;DNA2;MCM3;INO80 |
| DNA translocase activity | ATRX;FBXO18;RAD54B |
| chromatin binding | CUX1;UBE2T;PDX1;WHSC1;PRKAA1;IFT74;HDAC4;HINFP;PCGF2 |
| chromo shadow domain binding | SP100;TRIM28;ATRX;CHAF1A;NIPBL;LBR |
| helicase activity | TDRD12;HELQ;DDX39AA;SMARCA4;ZRANB3;DDX3;IFIH1;DDX19B;DDX51 |
| histone binding | BRD1;DTX3L;WDTC1;NPM1;NAP1L2;HIST1H3C;H3F3B;HIST1H4I;ATRX |
| methylated histone binding | L3MBTL2;CBX4;JHDM1D;ING4;ZMYND11;ING3;LOXL2;PHF2;GLYR1 |
| protein binding | NUP205;PYGB;KIT;RPUSD4;MT1X;KIF5A;UBAC1;STK4;ASGR2 |
| zinc ion binding | VDRB;GATA1A;TRAF6;RARGA;TRIM55B;BTR22;VPS8;SH3RF3;CBL |
ATRX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATRX here. Most of them are supplied by our site. Hope this information will be useful for your research of ATRX.
DAXX; Mecp2; RAD50; EZH2
- Q&As
- Reviews
Q&As (6)
Ask a questionThe research on ATRX gene mainly focuses on its function and regulatory mechanism, and its relationship with genetic diseases and cancer. So far, several important findings on ATRX gene function and regulation have been made.
Yes, ATRX gene expression is affected by a variety of regulatory factors, including transcription factor binding, DNA methylation status, etc. These regulatory mechanisms ensure the adaptability and stability of the ATRX gene.
ATRX gene mutation can lead to Alpha thalassemia/mental retardation syndrome X-linked. The main features of this syndrome include mental retardation, developmental delay, craniofacial deformity, anemia, etc.
ATRX gene is widely expressed in human body, but its expression level may vary in different tissues and organs. Its expression is higher in brain, kidney, muscle and other tissues.
ATRX genes may interact with other genes related to chromatin structure and DNA repair. For example, ATRX interacts with Death-domain associated protein (DAXX) to participate in chromatin repair and regulation.
Yes, the ATRX gene is involved in the regulation of DNA repair. Together with other proteins, it maintains the normal progression of DNA repair by maintaining chromatin structure and regulating gene expression.
Customer Reviews (3)
Write a reviewThe purity of ATRX is very high, which can ensure the reliability of the experimental results and also facilitate the subsequent experimental operation.
ATRX is really amazing. The results of every experiment are very consistent, which shows that its production process is very careful.
This band positions of ATRX in Western blot were accurate and showed good specificity.
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