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AUH

  • Official Full Name

    AU RNA binding protein/enoyl-CoA hydratase

  • Overview

    The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3 UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form.
  • Synonyms

    AUH; AU RNA binding protein/enoyl-CoA hydratase; AU RNA binding protein/enoyl Coenzyme A hydratase , AU RNA binding protein/enoyl Coenzyme A hydratase; methylglutaconyl-CoA hydratase, mitochondrial; 3 methylglutaconyl CoA hydratase; AU binding protein/enoyl CoA hydratase; AU RNA binding protein/enoyl CoA hydratase; AU RNA binding protein/enoyl Coenzyme A hydratase; AU specific RNA binding enoyl CoA hydratase; Methylglutaconyl CoA hydratase; Methylglutaconyl CoA hydratase mitochondrial; MGA Type I; OTTHUMP00000021631; OTTHUMP00000021632; 3-methylglutaconyl-CoA hydratase; AU-binding protein/Enoyl-CoA hydratase; AU-specific RNA-binding enoyl-CoA hydratase; AU RNA binding protein/enoyl-Coenzyme A hydratase; AU RN;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AUH-27419TH Recombinant Human AUH, His-tagged E.coli His 272 amino acids
Human AUH-3384H Recombinant Human AUH, 68-339 aa, His-tagged E.coli His
Human AUH-1035H Recombinant Human AUH protein, GST-tagged Wheat Germ GST
Human AUH-10072H Recombinant Human AUH, His-tagged E.coli His 1-310a.a.
Human AUH-3040H Recombinant Human AUH Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human AUH-6380H Recombinant Human AUH Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse AUH-2203M Recombinant Mouse AUH Protein Mammalian Cell His
Mouse Auh-682M Recombinant Mouse Auh Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse AUH-906M Recombinant Mouse AUH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse AUH-906M-B Recombinant Mouse AUH Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque AUH-479R Recombinant Rhesus monkey AUH Protein, His-tagged Mammalian Cell His
Rhesus Macaque AUH-308R Recombinant Rhesus Macaque AUH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque AUH-308R-B Recombinant Rhesus Macaque AUH Protein Pre-coupled Magnetic Beads HEK293
Zebrafish AUH-1005Z Recombinant Zebrafish AUH Mammalian Cell His
Chicken AUH-3078C Recombinant Chicken AUH Mammalian Cell His
Chicken AUH-4575C Recombinant Chicken AUH Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

AUH involved in several pathways and played different roles in them. We selected most pathways AUH participated on our site, such as Valine, leucine and isoleucine degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AUH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Valine, leucine and isoleucine degradationACADSB;DLDH;IL4I1;HMGCLL1;OXCT2B;ALDH2;HIBADHB;AOX1;HADHAB
Metabolic pathwaysALOX12;EXTL2;ALOX12B;UAP1L1;ST6GALNAC1;HAO2;NT5C3A;TYMS;DGAT2

AUH has several biochemical functions, for example, enoyl-CoA hydratase activity, mRNA 3-UTR binding, methylglutaconyl-CoA hydratase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AUH itself. We selected most functions AUH had, and list some proteins which have the same functions with AUH. You can find most of the proteins on our site.

Function Related Protein
enoyl-CoA hydratase activityECHS1;HADHA;HADHAB;HADHAA;AUH;EHHADH;HADHB
mRNA 3-UTR bindingTARDBP;CSDA;RNF40;ELAVL1;CPEB1B;SERBP1;RBM24;RNPS1;HNRNPC
methylglutaconyl-CoA hydratase activity

AUH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AUH here. Most of them are supplied by our site. Hope this information will be useful for your research of AUH.

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