aurka
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  • Official Full Name
  • aurora kinase A
  • Background
  • The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • AURKA; aurora kinase A; AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; PPP1R47; ARK-1; hARK1; aurora 2; Aurora-A kinase; IPL1-related kinase; aurora-related kinase 1; aurora/IPL1-like kinase; serine/threonine kinase 6; aurora/IPL1-related kinase 1; breast tumor-amplified kinase; breast-tumor-amplified kinase; serine/threonine-protein kinase 6; serine/threonine protein kinase 15; serine/threonine-protein kinase 15; serine/threonine-protein kinase aurora-A; protein phosphatase 1, regulatory subunit 47;
Cat.#:AURKA-10074HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AURKA, GST-tagged
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Cat.#:AURKA-1037HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AURKA protein, GST-tagged
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Cat.#:AURKA-27420THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AURKA, His-tagged
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Cat.#:AURKA-34HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human AURKA protein, Flag-tagged, Biotinylated
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Cat.#:AURORA A-3776HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human AURORA A protein, GST-tagged
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Cat.#:AURKA-2205MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AURKA Protein
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Cat.#:Aurka-3780MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Aurka, His-tagged
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Cat.#:AURKA-1060ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AURKA
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Cat.#:AURKA-106HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Aurora Kinase A, His-tagged
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Cat.#:AURKA-246HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Aurora Kinase A, GST-tagged, Active
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Cat.#:AURKA-549HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Aurora Kinase A, His-tagged
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Cat.#:AURKA-655HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Aurora Kinase A
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Cat.#:AURKA-683HTag:His
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human Aurora Kinase A, His-tagged
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Cat.#:Aurka-989MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Aurora Kinase A, GST-tagged
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Cat.#:AURKA-8562HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AURKA 293 Cell Lysate
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Cat.#:AURKA-8563HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AURKA 293 Cell Lysate
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Cat.#:AURKA-8564HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AURKA 293 Cell Lysate
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Involved Pathway

AURKA involved in several pathways and played different roles in them. We selected most pathways AURKA participated on our site, such as Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AURKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oocyte meiosis
PPP2R5A; CALML3; CALM4; RPS6KA3A; PPP1CA; PPP2R5EA; RPS6KA3B; RBX1; IGF1RA; CALM

Protein Function

AURKA has several biochemical functions, for example, ATP binding, histone serine kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AURKA itself. We selected most functions AURKA had, and list some proteins which have the same functions with AURKA. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein KIF2B; DDX43; CKMT2B; DDX11; PRKG1; ATP7A; TK2; KIF1C; BLK; NDUFA13
Function histone serine kinase activity
Related Protein AURKA; PRKAA2; AURKC; AURKB; PRKAA1; ATM
Function protein binding
Related Protein NQO2; GSK3B; PLEKHH2; CD79A; MRPS27; KPNB1; THBD; TIMP2; RNF5; TFDP2
Function protein kinase activity
Related Protein RPS6KA6; ROCK2A; FASTKD5; JAK2B; STK24; MAP3K5; CLK2A; ANKK1; RAF1A; ERBB4A
Function protein kinase binding
Related Protein PPP1R12C; PPP1CC; PAK2; TPX2; NEK6; TP73; XBP1; SNAP91; LSM2; MAVS
Function protein serine/threonine kinase activity
Related Protein HIPK4; NEK6; DCKL1B; STK19; CSNK1G3; STK4; SRPK1A; AURKB; DAPK1; OXSR1A
Function protein serine/threonine/tyrosine kinase activity
Related Protein PRKAA2; DYRK4; DYRK3; RPS6KB1; DYRK2; AKT1; RPS6KA1; DSTYK; DYRK1AA; MAP2K2
Function ubiquitin protein ligase binding
Related Protein SNX9; PACRG; EGFR; CUL9; TRIM28; UBOX5; GGN; MFN2; UBE2V2; MAGEA2

Interacting Protein

AURKA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AURKA here. Most of them are supplied by our site. Hope this information will be useful for your research of AURKA.
MYCN; TP73

AURKA Related Articles

Ramani, P; Nash, R; et al. Aurora kinase A is superior to Ki67 as a prognostic indicator of survival in neuroblastoma. HISTOPATHOLOGY 66:370-379(2015).
Shagisultanova, E; Dunbrack, RL; et al. Issues in interpreting the in vivo activity of Aurora-A. EXPERT OPINION ON THERAPEUTIC TARGETS 19:187-200(2015).