aurkb
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  • Official Full Name
  • aurora kinase B
  • Background
  • This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
  • Synonyms
  • AURKB; aurora kinase B; AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2; ARK-2; STK-1; aurora 1; aurora-1; aurora-B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora-related kinase 2; serine/threonine kinase 12; aurora/IPL1-related kinase 2; serine/threonine-protein kinase 5; serine/threonine-protein kinase 12; serine/threonine-protein kinase aurora-B; protein phosphatase 1, regulatory subunit 48; aurora- and Ipl1-like midbody-associated protein 1;
Cat.#:AURKB-1038HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AURKB protein, GST-tagged
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Cat.#:AURKB-26601THTag:
Source (Host):Species:Human
Product nameRecombinant Human AURKB
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Cat.#:AURKB-27422THTag:His
Source (Host):Species:Human
Product nameRecombinant Human AURKB, His-tagged
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Cat.#:AURKB-35HTag:Flag/His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human AURKB/INCENP protein, Flag/His-tagged, Biotinylated
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Cat.#:AURKB-46HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AURKB protein, MYC/DDK-tagged
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Cat.#:AURORA B-3778HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human AURORA B protein, GST-tagged
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Cat.#:AURKB-2207MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AURKB Protein
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Cat.#:Aurkb-3781MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Aurkb, His-tagged
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Cat.#:AURKB-904RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AURKB Protein
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Cat.#:AURKB-11846ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AURKB
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Cat.#:AURKB-5292HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Aurora Kinase B
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Cat.#:AURKB-231HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Aurora Kinase B, His-tagged
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Cat.#:AURKB-247HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Aurora Kinase B, GST-tagged, Active
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Cat.#:AURKB-684HTag:GST
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human Aurora Kinase B, GST-His
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Cat.#:AURKB-8560HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AURKB 293 Cell Lysate
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Involved Pathway

AURKB involved in several pathways and played different roles in them. We selected most pathways AURKB participated on our site, such as APC/C-mediated degradation of cell cycle proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Aurora A signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AURKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
APC/C-mediated degradation of cell cycle proteins
PSMD10; PSMA8; NEK2; ANAPC10; PSMD14; AURKB; PSMD5; PSME3; PSMD9; CDK2
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
PSMD14; AURKB; PSMD9; PSMD5; PSMA8; ANAPC10; PSME3; PSMD10; UBE2C
Aurora A signaling
TACC3; CENPA; NDEL1; TPX2; AURKB; AURKAIP1; TACC1; OAZ1; TDRD7; GADD45A
Aurora B signaling
SGOL1; CENPA; CDCA8; RACGAP1; NPM1; SEPT1; AURKB; SMC4; TACC1; EVI5
Aurora C signaling
AURKB; INCENP; AURKC
Cell Cycle
TEX15; SPC25; RAD21; CEP72; CDK5RAP2; NUP50; NEK9; CCND1; CDCA5; MSH5
Cell Cycle, Mitotic
CEP135; TMEM188; ARPP19B; SETB; SGOL2; ITGB3BP; FGFR1OP; LIN52; CDK11A; CLASP1
FOXM1 transcription factor network
CENPB; CENPA; CHEK2; CKS1B; FOXM1; AURKB

Protein Function

AURKB has several biochemical functions, for example, ATP binding, histone serine kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AURKB itself. We selected most functions AURKB had, and list some proteins which have the same functions with AURKB. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CHD2; EHD3; ACVR1L; UCKL1; CHD4; GATB; SYN2; CHORDC1; AK5L; ATAD5B
Function histone serine kinase activity
Related Protein ATM; AURKA; PRKAA1; AURKC; AURKB; PRKAA2
Function metal ion binding
Related Protein LHX2A; ZDHHC13; ZSCAN4D; ZFP276; BMX; RNF150A; SETDB1A; MYO9B; EIF2S2; ADPGK
Function protein binding
Related Protein HTR1A; C16orf87; C11orf67; MAGEA11; RND3; ARSA; NFASC; RASAL2; ZC3H15; SNW1
Function protein serine/threonine kinase activity
Related Protein TRIO; PRKCDA; RPS6KA4; SBK1; BMPR2B; STK38; MYO3A; ALPK1; SMOK2B; BCR
Function protein serine/threonine/tyrosine kinase activity
Related Protein SGK1; DYRK2; DYRK1AA; PRKAA2; RPS6KA2; PRKACA; RPS6KB1; RPS6KA1; MAP2K2; TESK2

Interacting Protein

AURKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AURKB here. Most of them are supplied by our site. Hope this information will be useful for your research of AURKB.
BIRC5; INCENP; SEPT1