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AURKB

  • Official Full Name

    aurora kinase B

  • Overview

    This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
  • Synonyms

    AURKB; aurora kinase B; AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2; ARK-2; STK-1; aurora 1; aurora-1; aurora-B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora-related kinase 2; serine/threonine kinase 12; aurora/IPL1-related kinase 2; serine/threonine-protein kinase 5; serine/threonine-protein kinase 12; serine/threonine-protein kinase aurora-B; protein phosphatase 1, regulatory subunit 48; aurora- and Ipl1-like midbody-associated protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • DDK
  • Flag
  • Flag|His
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AURKB-231H Recombinant Human Aurora Kinase B, His-tagged E.coli His
Human AURKB-684H Recombinant Human Aurora Kinase B, GST-His GST
Human AURKB-35H Recombinant Human AURKB/INCENP protein, Flag/His-tagged, Biotinylated Insect Cell Flag/His
Human AURKB-26601TH Recombinant Human AURKB N/A
Human AURKB-1038H Recombinant Human AURKB protein, GST-tagged Wheat Germ GST
Human AURKB-27422TH Recombinant Human AURKB, His-tagged His
Human AURORA B-3778H Recombinant Human AURORA B protein, GST-tagged Insect Cell GST full-length
Human AURKB-247H Recombinant Human Aurora Kinase B, GST-tagged, Active Sf9 Insect Cell GST
Human AURKB-5292H Recombinant Human Aurora Kinase B Sf9 Insect Cell N/A
Human AURKB-46H Recombinant Human AURKB protein, MYC/DDK-tagged HEK293 Myc/DDK
Human AURKB-8560HCL Recombinant Human AURKB 293 Cell Lysate HEK293 N/A
Human AURKB-05H Recombinant Human AURKB (D200A) Mutant Protein, GST-tagged Insect Cell GST
Human AURKB-5410H Recombinant Human AURKB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AURKB-3924H Recombinant Human AURKB protein, His-tagged E.coli His 1-371 aa
Human AURKB-9695HFL Recombinant Full Length Human AURKB protein, Flag-tagged Mamanlian cells Flag
Human AURKB-4230HF Active Recombinant Full Length Human AURKB Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-344(end)
Human AURKB-8990HF Active Recombinant Full Length Human AURKB Protein, GST-tagged Insect (sf21) GST 1-344(end)
Human AURKB-1104HF Recombinant Full Length Human AURKB Protein, GST-tagged In Vitro Cell Free System GST 344 amino acids
Human AURKB-1112H Recombinant Human AURKB Protein (A2-A344), Tag Free Insect Cell No tag A2-A344
Human AURKB-1113H Recombinant Human AURKB Protein (A2-A344), GST tagged Insect Cell GST A2-A344
Mouse Aurkb-3781M Recombinant Mouse Aurkb, His-tagged E.Coli or Yeast His 345
Mouse AURKB-2207M Recombinant Mouse AURKB Protein Mammalian Cell His
Mouse Aurkb-1789M Recombinant Mouse Aurkb Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse AURKB-909M Recombinant Mouse AURKB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse AURKB-909M-B Recombinant Mouse AURKB Protein Pre-coupled Magnetic Beads HEK293
Rat AURKB-904R Recombinant Rat AURKB Protein Mammalian Cell His
Rat AURKB-560R Recombinant Rat AURKB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AURKB-560R-B Recombinant Rat AURKB Protein Pre-coupled Magnetic Beads HEK293
Rat Aurkb-279R Recombinant Rat Aurkb Protein, His-tagged E.coli N-His Gly92-Pro339
Zebrafish AURKB-11846Z Recombinant Zebrafish AURKB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AURKB Related Research Area

AURKB involved in several pathways and played different roles in them. We selected most pathways AURKB participated on our site, such as APC/C-mediated degradation of cell cycle proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Aurora A signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AURKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
APC/C-mediated degradation of cell cycle proteinsNEK2;PSMD9;UBE2C;PSMA8;PSMD14;ANAPC10;PSMD10;CDK2;AURKB
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1PSMD10;PSMD5;PSMD14;PSMA8;AURKB;PSME3;ANAPC10;PSMD9;UBE2C
Aurora A signalingCENPA;NDEL1;OAZ1;TACC1;AURKB;GADD45A;TDRD7;TACC3;AURKAIP1
Aurora B signalingAURKB;SEPT1;TACC1;INCENP;DES;KIF2C;NPM1;RACGAP1;KIF20A
Aurora C signalingINCENP;AURKC;AURKB
Cell CycleCDKN2C;BUB1;TUBB4A;GINS1;PCNA;MSH4;GADD45A;NDEL1A;POT1A
Cell Cycle, MitoticMIS12;HIST3H2BB;NCAPD3;KNTC1;CEP76;ANKLE2;CENPJ;CDK6;NEDD1
FOXM1 transcription factor networkCKS1B;CHEK2;CENPA;FOXM1;AURKB;CENPB

AURKB has several biochemical functions, for example, ATP binding, histone serine kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AURKB itself. We selected most functions AURKB had, and list some proteins which have the same functions with AURKB. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTTK;KIFC2;UBE2B;PFAS;LARS;CAMK1G;P2RX3;DNA2;PRKD2
histone serine kinase activityAURKC;PRKAA1;PRKAA2;AURKB;ATM;AURKA
metal ion bindingZNF643;PRMT3;ANKMY2;CYP2D9;COL10A1;ZSWIM7;TAX1BP1B;ZNF821;BGLAP2
protein bindingMARVELD3;TAF3;RBBP8;DCUN1D1;WDHD1;PIN1;AP5Z1;KRTAP4-12;BEX2
protein serine/threonine kinase activityNEK12;CAMKK1A;NEK2;MKNK1;TSSK6;MAPK6;MAPKAPK5;PAK1;ULK3
protein serine/threonine/tyrosine kinase activityRPS6KA2;RPS6KB1;DYRK2;CLK2;DSTYK;MAP2K2;PRKAA2;DYRK1B;CLK4

AURKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AURKB here. Most of them are supplied by our site. Hope this information will be useful for your research of AURKB.

BIRC5; INCENP; SEPT1

  • Q&As
  • Reviews

Q&As (6)

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What are the interactions between AURKB protein and cell cycle regulatory proteins? 12/03/2022

AURKB protein interacts with a variety of cell cycle regulatory proteins, including Cdk1, INCENP, Survivin, etc., to regulate the progression of cell mitosis.

What are the intracellular substrates of AURKB protein? 09/09/2022

The substrates of AURKB include chromosome-associated proteins, cytoskeletal proteins and other cell cycle regulatory proteins. Phosphorylation modification of these substrates regulates chromosome segregation and cell division during mitosis.

What is the cellular localization of AURKB protein? 06/30/2021

AURKB protein is mainly located in the nucleus and cytoplasm and participates in the regulation of cell mitosis.

What is the expression pattern of AURKB gene? 08/11/2020

The expression of the AURKB gene is regulated by cell cycle regulators and other transcription factors and is mainly expressed in the mitotic phase of cells.

How does AURKB protein activity work? 03/14/2020

The activity of AURKB protein is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.

At what stage of cell mitosis does AURKB protein reach its peak expression? 04/08/2019

The protein reaches its peak expression during early and metaphase of cell mitosis and is closely associated with chromosome segregation and cell division.

Customer Reviews (3)

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Reviews
12/28/2021

    AURKB's exceptional repeatability allows for its reliable use in a range of applications, making it a top choice for researchers.

    08/31/2021

      Very pure and can be used with confidence.

      02/03/2019

        The quality is very high and very reliable.

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