Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Avpr2

  • Official Full Name

    arginine vasopressin receptor 2

  • Overview

    This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these extrarenal receptors are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.
  • Synonyms

    AVPR2; arginine vasopressin receptor 2; DIR, DIR3; vasopressin V2 receptor; nephrogenic diabetes insipidus; V2R; ADHR; Antidiuretic hormone receptor; AVP R2; AVPR 2; AVPR V2; DI1; DIR 3; DIR; DIR3; MGC126533; MGC138386; NDI; Renal type arginine vasopressin receptor; Renal-type arginine vasopressin receptor; V2 receptor; V2R_HUMAN; Vasopressin V2;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pig
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Flag
  • His|SUMO
  • N/A
  • Tag
  • Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AVPR2-8557HCL Recombinant Human AVPR2 293 Cell Lysate HEK293 N/A
Human AVPR2-1052HFL Recombinant Human AVPR2 protein, His&Flag-tagged HEK293 His&Flag 1-371 aa
Mouse AVPR2-2217M Recombinant Mouse AVPR2 Protein Mammalian Cell His
Mouse AVPR2-915M-B Recombinant Mouse AVPR2 Protein Pre-coupled Magnetic Beads HEK293
Mouse AVPR2-915M Recombinant Mouse AVPR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AVPR2-908R Recombinant Rat AVPR2 Protein Mammalian Cell His
Rat AVPR2-564R Recombinant Rat AVPR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AVPR2-564R-B Recombinant Rat AVPR2 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL27506BF Recombinant Full Length Bovine Vasopressin V2 Receptor(Avpr2) Protein, His-Tagged E.coli expression system His Full Length (1-370)
Canis lupus familiaris (Dog) (Canis familiaris) RFL11287CF Recombinant Full Length Dog Vasopressin V2 Receptor(Avpr2) Protein, His-Tagged E.coli expression system His Full Length (1-370)
Homo sapiens (Human) RFL1432HF Recombinant Full Length Human Vasopressin V2 Receptor(Avpr2) Protein, Tag-Free E.coli expression system Tag-Free Full Length (1-371)
Mus musculus (Mouse) RFL21152MF Recombinant Full Length Mouse Vasopressin V2 Receptor(Avpr2) Protein, His-Tagged E.coli expression system His Full Length (1-371)
Rattus norvegicus (Rat) RFL31288RF Recombinant Full Length Rat Vasopressin V2 Receptor(Avpr2) Protein, His-Tagged E.coli expression system His Full Length (1-371)
Sus scrofa (Pig) RFL801SF Recombinant Full Length Pig Vasopressin V2 Receptor(Avpr2) Protein, His-Tagged E.coli expression system His Full Length (1-370)
Pig AVPR2-2048P Recombinant Pig AVPR2 Protein (292-370 aa), His-SUMO-tagged E.coli His/SUMO 292-370 aa
Chicken AVPR2-3126C Recombinant Chicken AVPR2 Mammalian Cell His
Kit-0980 Plasma Protein Binding Kit N/A
Kit-1097 Overall Exosome Capture and Quantification Assay Kit (Human Urine, Colorimetric) N/A
Kit-1124 AVPR2 CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-1125 cAMP AVPR2 CHO-K1 GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Avpr2 involved in several pathways and played different roles in them. We selected most pathways Avpr2 participated on our site, such as Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Avpr2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Phospholipase D signaling pathwayLPAR4;LPAR6;INS;RALB;GAB1;PLCG2;SHC1;PIK3R2;TSC2
Neuroactive ligand-receptor interactionFPR2;EDNRAA;AVPR2;NTSR2;HTR5A;PLG;MAS1;TACR3L;LPAR6

Avpr2 has several biochemical functions, for example, peptide binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Avpr2 itself. We selected most functions Avpr2 had, and list some proteins which have the same functions with Avpr2. You can find most of the proteins on our site.

Function Related Protein
peptide bindingTRHDE;ANPEP;CMA1;CRHBP;GPR37L1;ANPEPA;ERAP1;GNRHR4;AVPR2
protein bindingSOAT1;UNKL;PAAF1;MAGEA4;SUFU;REV1;RPS10;DENR;C1orf51

Avpr2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Avpr2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Avpr2.

  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the role of AVPR2 protein in urine concentration? 04/27/2022

This protein promotes the production of cAMP in renal tubular epithelial cells by activating adenylyl cyclase-adenylyase system, thereby increasing the expression and transport of aquaporin-2 and increasing urine concentration.

What signal transduction pathways do AVPR2 proteins associate with? 09/07/2021

The protein is associated with signal transduction pathways related to adenylyl cyclase-adenylyl enzyme system and increases intracellular cAMP levels by activating adenylyl cyclase.

Which diseases are associated with AVPR2 protein mutations? 05/24/2021

Mutations in the AVPR2 protein are associated with nephrogenic diabetes insipidus, a disorder in which renal tubules are insensitive to arginine vasopressin, resulting in a failure to concentrate urine.

In which tissues is AVPR2 protein expressed? 08/22/2020

It is mainly expressed in renal tubules, especially at the apices of collecting duct cells.

What are the prospects of AVPR2 protein in drug development? 06/05/2020

Because of its involvement in the regulation of urine concentration and dilution, AVPR2 protein is considered a potential target for drug development. Researchers are exploring the development of drugs that interact with AVPR2 protein for the treatment of related diseases

Which hormone does AVPR2 protein bind to? 02/13/2019

AVPR2 protein binds to the antidiuretic hormone arginine vasopressin and, through its binding to arginine vasopressin, triggers the activation of intracellular signal transduction pathways.

Customer Reviews (3)

Write a review
Reviews
09/05/2022

    Beacuse preparation cost is very low and the cost performance is very high.

    09/26/2019

      The activity retention time is very long and the activity can be maintained for a long time.

      03/23/2019

        This labeling effect is very good, and fluorescent labeling can be performed, etc.

        Ask a Question for All Avpr2 Products

        Required fields are marked with *

        My Review for All Avpr2 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends