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AWAT2

  • Official Full Name

    acyl-CoA wax alcohol acyltransferase 2

  • Overview

    This gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it catalyzes the synthesis of diacylglycerols and retinyl esters.
  • Synonyms

    AWAT2; acyl-CoA wax alcohol acyltransferase 2; DGAT2L4, diacylglycerol O acyltransferase 2 like 4; MFAT; multifunctional O acyltransferase; Acyl CoA wax alcohol acyltransferase 2; DC4; Diacylglycerol O acyltransferase 2 like 4; Diacylglycerol O acyltransferase candidate 4; Long chain alcohol O fatty acyltransferase 2; Wax synthase 2; Wax synthase; WS; multifunctional O-acyltransferase; diacylglycerol O-acyltransferase candidate 4; long-chain-alcohol O-fatty-acyltransferase 2; diacylglycerol O-acyltransferase 2-like protein 4; DGAT2L4;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AWAT2-8555HCL Recombinant Human AWAT2 293 Cell Lysate HEK293 N/A
Homo sapiens (Human) RFL14558HF Recombinant Full Length Human Acyl-Coa Wax Alcohol Acyltransferase 2(Awat2) Protein, His-Tagged E.coli expression system His Full Length (1-333)
Mus musculus (Mouse) RFL1534MF Recombinant Full Length Mouse Acyl-Coa Wax Alcohol Acyltransferase 2(Awat2) Protein, His-Tagged E.coli expression system His Full Length (1-333)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AWAT2 Related Articles

AWAT2 involved in several pathways and played different roles in them. We selected most pathways AWAT2 participated on our site, such as Acyl chain remodeling of DAG and TAG, Arachidonic acid metabolism, Glycerophospholipid biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AWAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Acyl chain remodeling of DAG and TAGAWAT2;MGLL;AWAT1;DGAT1B
Arachidonic acid metabolismPTGES2;ALOX15;ALOX15B;CBR1;PTGS1;CYP1A1;AKR1C3;PTGDSB;GGT1
Glycerophospholipid biosynthesisPNPLA8;ABHD3;CPNE6;DGAT1B;CDIPT;GPAT2;PLBD1;CPNE3;AWAT1
MetabolismDHCR7;CYP4T8;CIAO1;CYP2W1;HSD17B11;ARSK;KCNS3;CSPG5B;SLC25A15A
Metabolism of lipids and lipoproteinsMED6;VAPB;ACOT12;PPM1L;FABP12;ARSK;ACER1;INSIG1;SPTLC1
Phospholipid metabolismDGAT1B;CEPT1;CHKA;CPNE1;PNPLA8;PEMT;PHOSPHO1;AWAT2;PLD6

AWAT2 has several biochemical functions, for example, long-chain-alcohol O-fatty-acyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AWAT2 itself. We selected most functions AWAT2 had, and list some proteins which have the same functions with AWAT2. You can find most of the proteins on our site.

Function Related Protein
long-chain-alcohol O-fatty-acyltransferase activityAWAT2;AWAT1

AWAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AWAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AWAT2.

Rodriguez, GM; Tashiro, Y; et al. Expanding ester biosynthesis in Escherichia coli. NATURE CHEMICAL BIOLOGY 10:259-+(2014).
Guo, DY; Zhu, J; et al. Metabolic engineering of Escherichia coli for production of fatty acid short-chain esters through combination of the fatty acid and 2-keto acid pathways. METABOLIC ENGINEERING 22:69-75(2014).
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