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AADAC

  • Official Full Name

    arylacetamide deacetylase (esterase)

  • Overview

    Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which;catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens.
  • Synonyms

    AADAC; arylacetamide deacetylase (esterase); arylacetamide deacetylase; CES5A1; DAC; Aada; OTTHUMP00000216826; OTTHUMP00000216827;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • E.coli
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO|Myc
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AADAC-011H Recombinant Human AADAC Protein, GST-tagged Wheat Germ GST
Human AADAC-3650H Recombinant Human AADAC, His-tagged E.Coli or Yeast His 399
Human AADAC-9160HCL Recombinant Human AADAC 293 Cell Lysate HEK293 N/A
Human AADAC-9288HFL Recombinant Full Length Human AADAC protein, Flag-tagged Mamanlian cells Flag
Human AADAC-2474H Recombinant Human AADAC protein, His-tagged E.coli His 24-399aa
Human AADAC-2183H Recombinant Human AADAC Protein (24-399 aa), His-SUMO-Myc-tagged E.coli His/SUMO/Myc 24-399 aa
Human AADAC-3902H Recombinant Human AADAC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AADAC-745HF Recombinant Full Length Human AADAC Protein, GST-tagged In Vitro Cell Free System GST 399 amino acids
Human AADAC-3747H Recombinant Human AADAC protein, GST-tagged E.coli GST 24-96 aa
Human AADAC-2193H Recombinant Human AADAC protein, His-tagged Insect Cell His 24-399aa
Human AADAC-2805H Recombinant Human AADAC protein, His-tagged E.coli His 24-96 aa
Mouse AADAC-1056M Recombinant Mouse AADAC Protein Mammalian Cell His
Mouse AADAC-170M-B Recombinant Mouse AADAC Protein Pre-coupled Magnetic Beads HEK293
Mouse AADAC-170M Recombinant Mouse AADAC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Aadac-1449M Recombinant Mouse Aadac Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat AADAC-381R Recombinant Rat AADAC Protein Mammalian Cell His
Rat AADAC-36R Recombinant Rat AADAC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AADAC-36R-B Recombinant Rat AADAC Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL-15786HF Recombinant Full Length Human Arylacetamide Deacetylase(Aadac) Protein, His-Tagged E.coli expression system His Full Length (1-399)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AADAC Related Articles

AADAC involved in several pathways and played different roles in them. We selected most pathways AADAC participated on our site, such as Biological oxidations, Metabolism, Phase 1 - Functionalization of compounds, which may be useful for your reference. Also, other proteins which involved in the same pathway with AADAC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Biological oxidationsGGTLC1;CYP2C8;FAM84B;CYP21A2;GSTO2;CYP2AD6;COMT;CYP2D6;CYP2W1
MetabolismACOT11B;NEU3;ADSSL1;TIMMDC1;B3GNT3;CYP2R1;PEMT;ATP5L;CLPS
Phase 1 - Functionalization of compoundsCYP2U1;CYP2Y3;CYP2W1;CYP2AD3;CYP2V1;CYP26A1;CYP2N13;CYP2K17;CYP2C18

AADAC has several biochemical functions, for example, catalytic activity, deacetylase activity, lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AADAC itself. We selected most functions AADAC had, and list some proteins which have the same functions with AADAC. You can find most of the proteins on our site.

Function Related Protein
catalytic activityMDH1AA;APOBEC2A;RAG1;IMPDH1A;AOAH;CAPN3;HYAL6;PBLD1;PARP3
deacetylase activityC6orf130;HDAC2;MAPK1IP1L;SIRT1;NDST1;MACROD1;NDST4;NDST3;HDAC1
lipase activityNOTUM1A;LIPN;LIPM;ABHD2B;Aadacl3;CES1C;Cel;CELL;LIPK
serine hydrolase activityCELA2A;AADAC;ACHE
triglyceride lipase activityLIPF;CES3;Cel;PNPLA2;LIPE;PNLIPRP3;LIPC;PNLIP;PNPLA4

AADAC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AADAC here. Most of them are supplied by our site. Hope this information will be useful for your research of AADAC.

Ito, Y; Fukami, T; et al. An Orphan Esterase ABHD10 Modulates Probenecid Acyl Glucuronidation in Human Liver. DRUG METABOLISM AND DISPOSITION 42:2109-2116(2014).
Shimizu, M; Fukami, T; et al. Screening of Specific Inhibitors for Human Carboxylesterases or Arylacetamide Deacetylase. DRUG METABOLISM AND DISPOSITION 42:1103-1109(2014).
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