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ABCA7

  • Official Full Name

    ATP-binding cassette, sub-family A (ABC1), member 7

  • Overview

    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is widely expressed with highest detection in spleen and hematopoietic tissues. The function of this protein has not yet been determined; however, a related human protein is thought to play a role in lipid homeostasis in cells of the immune system.
  • Synonyms

    ABCA7; ATP-binding cassette, sub-family A (ABC1), member 7; ATP-binding cassette sub-family A member 7; ABC transporter ABCA7; ABC transporter member 7; ABCA SSN; ABCX; ATP binding cassette sub family A (ABC1) member 7; ATP binding cassette sub family A member 7; ATP binding Cassette Transporter A7; FLJ40025; Macrophage ABC transporter; OTTMUSP00000043312; Abc51;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ABCA7-753H Recombinant Human ABCA7 Mammalian Cell His
Human ABCA7-301327H Recombinant Human ABCA7 protein, GST-tagged E.coli GST Thr86-Ser214
Human ABCA7-1677H Recombinant Human ABCA7 protein, His & GST-tagged E.coli His/GST Glu53~Leu249
Human ABCA7-2400H-B Recombinant Human ABCA7 Protein Pre-coupled Magnetic Beads HEK293
Human ABCA7-2400H Recombinant Human ABCA7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ABCA7-3906H Recombinant Human ABCA7 protein, His-tagged E.coli His 86-214 aa
Mouse ABCA7-1083M Recombinant Mouse ABCA7 Protein Mammalian Cell His
Mouse ABCA7-184M-B Recombinant Mouse ABCA7 Protein Pre-coupled Magnetic Beads HEK293
Mouse ABCA7-184M Recombinant Mouse ABCA7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ABCA7-395R Recombinant Rat ABCA7 Protein Mammalian Cell His
Rat ABCA7-50R Recombinant Rat ABCA7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ABCA7-50R-B Recombinant Rat ABCA7 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ABCA7 Related Articles

ABCA7 involved in several pathways and played different roles in them. We selected most pathways ABCA7 participated on our site, such as ABC transporters, ABC transporters in lipid homeostasis, ABC-family proteins mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ABC transportersAbcb1b;ABCB8;ABCA13;ABCA1B;ABCG2;ABCA5;ABCC1;ABCB4;ABCD2
ABC transporters in lipid homeostasisABCA7;ABCG4B;APOA1B;ABCD3B
ABC-family proteins mediated transportABCA7;ABCA4A;ABCC2;EIF2S3;EIF2S1;EIF2S1A;APOA1B;KCNJ11;CFTR
Transmembrane transport of small moleculesSLC22A12;ANO5B;APOD;SLC2A13B;LCN12;CLCN5;SLC26A7;BEST1;SLCO3A1

ABCA7 has several biochemical functions, for example, ATP binding, contributes_to ATPase activity, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCA7 itself. We selected most functions ABCA7 had, and list some proteins which have the same functions with ABCA7. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPKLR;MAPK9;PIK3C3;MTOR;CLCN4;GTF2F2;KIF15;HSPA6;TTLL10
contributes_to ATPase activityATP5C1;ATP5O;ATP5I;ATP6V1H;ATP5J2;ABCG8;ATP5F1;RUVBL2;ATP5A1
ATPase activity, coupled to transmembrane movement of substancesABCA5;TAP1;ABCA7;ABCA4A;ABCC11;DPY19L2;ABCC1;ABCD1;IPO8
apolipoprotein A-I receptor activityABCA1;ABCA7
cholesterol transporter activityAPOEB;ABCG4B;ABCA7;ABCA4;APOA1A;APOA4B.1;APOA5;APOA4B.2;APOE
phospholipid transporter activityMFSD2A;MTTP;OSBPL5;CETP;ABCG1;APOA1;ABCA4A;GLTPD1;ABCA1B
transporter activitySLC2A11B;ABCA4;SLC12A10.1;SLC37A4A;AP1B1;Slc4a2;AP3D1;SLC2A11L;SLC5A12

ABCA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCA7.

Morales, CR; Ni, XY; et al. ABCA17 mediates sterol efflux from mouse spermatozoa plasma membranes. HISTOLOGY AND HISTOPATHOLOGY 27:317-328(2012).
Morales, CR; Marat, AL; et al. ATP-binding cassette transporters ABCA1, ABCA7, and ABCG1 in mouse spermatozoa. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 376:472-477(2008).
  • Q&As
  • Reviews

Q&As (9)

Ask a question
Are your recombinant protein products full-length proteins or protein domains? 04/14/2023

Our products have full-length proteins and protein parts, you can check the details in the product overview.

What biological processes are ABCA7 involved in? 04/14/2023

ABCA7 is involved in lipid transport, phagocytosis, visual learning, and positive regulation of cholesterol efflux.

Do you have biotinylated ABCA7 protein products? 04/14/2023

We do. Our products can be customized according to different needs of customers, and the labels that can be added include biotin, fluorescein, alexa flour, APC, etc.

How does abca7 contribute to AD-related pathology? 04/14/2023

ABCA7 loss of function significantly increases amyloid precursor protein proteolysis and amyloid-β production.

Which expression systems can be used to express the abca7 gene? 04/14/2023

Expression systems such as HEK293 and CHO can be used.

Can a GFP tag be added to study protein function? 04/14/2023

Some studies added green fluorescent protein to the C-terminus of ABCA7, which did not affect the lipid release reaction.

Is the ABCA7 variant a susceptibility locus for late-onset AD? 04/14/2023

Cumulative genetic evidence collected through genome-wide studies (GWAS) has identified ABCA7 variants as late-onset AD susceptibility loci, including rs3764650, rs3752246, and rs115550680.

How ABCA7 limits amyloid-beta production? 04/14/2023

ABCA7 limits amyloid-β production by regulating amyloid-β A4 precursor protein endocytosis and/or processing.

Does ABCA7 transport phosphatidylcholine? 04/14/2023

it does. But when phosphatidylcholine and phosphatidylserine are present at the same time, ABCA7 will preferentially transport phosphatidylserine.

Customer Reviews (2)

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Reviews
06/19/2021

    Rich catalog of recombinant protein products, no need to look for protein products everywhere.

    07/12/2020

      Customizable, very convenient

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