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ABL1

  • Official Full Name

    c-abl oncogene 1, non-receptor tyrosine kinase

  • Overview

    The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008]
  • Synonyms

    ABL1; c-abl oncogene 1, non-receptor tyrosine kinase; ABL; JTK7; p150; c-ABL; v-abl; c-ABL1; bcr/abl; tyrosine-protein kinase ABL1; proto-oncogene c-Abl; bcr/c-abl oncogene protein; Abelson tyrosine-protein kinase 1; c-abl oncogene 1, receptor tyrosine kinase; proto-oncogene tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Human
  • Human
  • Mouse
  • E. coli
  • E.coli
  • HEK293
  • human plasma
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • Sf9 insect cells
  • Wheat Germ
  • C
  • His
  • DDK
  • Flag
  • GST
  • GST|His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ABL1-982H Active Recombinant Human ABL1 protein, His-tagged Insect Cell His 27-end
Human ABL1-241H Active Recombinant Human ABL1 (T315I), GST-tagged Sf9 Insect Cell GST
Human ABL1-096H Active Recombinant Human ABL1 Protein, His-Tagged Insect Cell His
Human ABL1-242H Active Recombinant Human ABL1 (Y253F), GST-tagged Sf9 Insect Cell GST
Human ABL1-097H Active Recombinant Human ABL1 Protein, GST-His-Tagged Insect Cell GST/His
Human ABL1-07H Active Recombinant Human ABL1(T315I)(27-end) Mutation Protein, N-His-tagged Sf21 His 27–end, T315I
Human ABL1-04H Active Recombinant Human ABL1(H396P)(27-end) Mutation Protein, N-His-tagged Sf21 His 27–end, H396P
Human ABL1-05H Active Recombinant Human ABL1(M351T)(27-end) Mutation Protein, N-His-tagged Sf21 His 27–end, M351T
Human ABL1-06H Active Recombinant Human ABL1(Q252H)(27-end) Mutation Protein, N-His-tagged Sf21 His 27–end, Q252H
Human ABL1-08H Active Recombinant Human ABL1(Y253F)(27-end) Mutation Protein, N-His-tagged Sf21 His 27-end, Y253F
Human ABL1-09H Active Recombinant Human ABL1(27-end) Protein, N-His-tagged Sf21 His 27-end
Human ABL1-162H Recombinant Human ABL1, SH3 Domain, GST-tagged E.coli GST
Human ABL1-783H Active Recombinant Human ABL1 protein(Pro137-Ser554), GST-tagged Insect Cells N-GST Pro137-Ser554
Human ABL1-380H Recombinant Human ABL1 Mammalian Cell His
Human ABL1-28H Recombinant Human ABL1 Protein, Flag-tagged, Biotinylated Insect Cell Flag
Human ABL1-098H Recombinant Human ABL1 Protein, GST-Tagged Wheat Germ GST
Human ABL1-676HCL Recombinant Human ABL1 cell lysate Insect Cell N/A
Human ABL1-2962H Recombinant Human ABL1 protein, His-tagged E.coli His 801-900 aa
Human ABL1-7728HF Active Recombinant Full Length Human ABL1 Protein, His-tagged Insect (sf21) His 2-1130(end)
Human ABL1-1204H Recombinant Human ABL1 Protein (4-194 aa), GST-tagged E.coli GST 4-194 aa
Human ABL1-783HAF555 Recombinant Human ABL1 Protein, GST-tagged, Alexa Fluor 555 conjugated Insect Cell GST 645
Human ABL1-2406H Recombinant Human ABL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ABL1-9477HF Active Recombinant Full Length Human ABL1 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 2-1130(end)
Human ABL1-783HAF488 Recombinant Human ABL1 Protein, GST-tagged, Alexa Fluor 488 conjugated Insect Cell GST 645
Human ABL1-783HF Recombinant Human ABL1 Protein, GST-tagged, FITC conjugated Insect Cell GST 645
Human ABL115437H Recombinant Human ABL1 (229-515) Protein, N-His-tagged E.coli His
Human ABL1-2406H-B Recombinant Human ABL1 Protein Pre-coupled Magnetic Beads HEK293
Human ABL1-783HAF647 Recombinant Human ABL1 Protein, GST-tagged, Alexa Fluor 647 conjugated Insect Cell GST 645
Human ABL1-7999HF Active Recombinant Full Length Human ABL1 Protein, His-tagged Insect (sf21) His 2-1130(end)
Human ABL1-9466HF Active Recombinant Full Length Human ABL1 Protein, His-tagged Insect (sf21) His 2-1130(end)
Human ABL1-16H Recombinant Active Human ABL1 (Y245F Y412F) Protein (27-end), N-His-tagged Sf9 insect cells N-His 27-end
Human ABL1-6348HF Active Recombinant Full Length Human ABL1 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 2-1130(end)
Human ABL1-15H Recombinant Active Human ABL1 (Y245F) Protein (27-end), N-His-tagged Sf9 insect cells N-His 27-end
Human ABL1-2499H Recombinant Human ABL1 protein(531-650 aa), C-His-tagged E. coli C-His 531-650 aa
Human ABL1-618H Native Human C-abl Oncogene 1, Receptor Tyrosine Kinase human plasma N/A
Human ABL1-0763H Recombinant Human ABL1 Protein (L2-R1130), GST tagged Insect Cell GST L2-R1130
Mouse Abl1-982M Active Recombinant mouse Abl1, His-tagged Sf9 Insect Cell His
Mouse Abl1-100M Active Recombinant Mouse Abl1 Protein, His-Tagged Insect Cell His
Mouse ABL1-10M Active Recombinant Mouse ABL1(27-1123) Protein, N-His-tagged Sf21 His 27-1123 aa
Mouse Abl1-232M Recombinant Mouse ABL1, His-tagged, Active Sf9 Insect Cell His
Mouse ABL1-1141M Recombinant Mouse ABL1 Protein Mammalian Cell His
Mouse ABL1-222M-B Recombinant Mouse ABL1 Protein Pre-coupled Magnetic Beads HEK293
Mouse ABL1-222M Recombinant Mouse ABL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ABL1 Related Articles
  • ABL1 Related Research Area

ABL1 involved in several pathways and played different roles in them. We selected most pathways ABL1 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayRAF1;HBEGFA;PAK2B;CBL;NCK2;CAMK2D;RAF1A;RAF1B;PIK3R5
Ras signaling pathwaySHC4;PIK3CG;FIGF;PAK6;PLD2;ZAP70;ABL2;FGF4;PLA2G3
Cell cycleFGFR1OP;ENSAB;TFDP1A;MCM7;USO1;CEP70;TUBB4A;CKS1B;HTATIP
Axon guidanceSCN8A;SIAH2;KLB;DPYSL5;KDR;FGF10B;IL17RD;SCN4A;ABLIM1
Neurotrophin signaling pathwayYWHAE;RAC1;GAB1;BAD;CALML5;FOXO3;BCL2;CAMK2A;NTRK1
Pathogenic Escherichia coli infectionWASL;ARHGEF2;ROCK2;TUBB1;EZR;LY96;OCLN;CD14;WAS
ShigellosisHCLS1;UBE2D2;ITGA5;PFN1;PFN2;IKBKG;MAPK11;ELMO1;CDC42
Pathways in cancerMMP1A;FGF13;TGFBR2;MMP9;WNT3;FZD5;PIAS2;FGF1;PIK3R3
MicroRNAs in cancerKIF23;CDC25C;TNC;FOXP1;RECK;CD44;RAF1;ZEB1;MAPK7
Chronic myeloid leukemiaTP53;BCR;HRAS;SOS1;CBLB;TGFB1;SHC3;MAP2K1;SHC2
Viral myocarditisITGAL;CD28;HLA-G;CCND1;CASP9;HLA-DQA1;HLA-B;ITGB2;HLA-A

ABL1 has several biochemical functions, for example, ATP binding, DNA binding, SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABL1 itself. We selected most functions ABL1 had, and list some proteins which have the same functions with ABL1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingIGF1RB;ACTC1B;PDPK1;CDK18;SKIV2L2;CHD6;GUK1;ABCB9;SRPK1
DNA bindingPOGK;E2F2;RXRBB;HOXA5;ZNF143B;SCML1;LCOR;SEBOX;FOXO6
SH3 domain bindingPAK3;QKIA;CYBA;INPP5J;EPS15;ADAM19;PDE4D;VASPA;PTTG2
actin monomer bindingPFN2;MKL1;MTSS1;KLHL8;LMOD3;TWF2;TMSB;ABL2;ABL1
magnesium ion bindingPPA1;ITPK1;FAN1;PPM1BA;HACL1;NLK;GLUL;PGM5;NT5C1AA
manganese ion bindingFEN1;PAPOLA;TDP2;GALNT3;CDIPT;FAM20C;HMGCL;PPM1AA;DCP2
mitogen-activated protein kinase bindingGTF2I;ABL1;SIRT1;CDK5RAP3;ACE;MAPKAPK5;DUSP2;NBR1;ATF7
nicotinate-nucleotide adenylyltransferase activityNMNAT2;NMNAT3;NMNAT1;ABL1
non-membrane spanning protein tyrosine kinase activityDYRK1A;CSK;CLK1;JAK2A;BTK;FYNB;WEE1;RIPK2;JAK3
proline-rich region bindingABL1;FAM59A;APBB1;YAP1;ITSN1;BAIAP2;TCERG1;ABI2;CYLD
protein C-terminus bindingPRDX3;SIRT1;CEP120;ERCC2;PQBP1;MYO1C;STIP1;HIC2;GRIP1
protein bindingPDE4C;GRB7;CYFIP1;IYD;CD84;IGFN1;KIF9;DLGAP1;IL5RA
protein kinase activityACVR1L;GUCY2C;CASKA;DAPK2A;PRPF4BB;TGFBR1B;RIPK1L;MAP4K3;PHKG1A
protein tyrosine kinase activityCAMKK2;Aatk;MAP2K6;TNK2;PTK7A;MAP2K7;CSF1RA;FYNA;EGFR
receptor bindingBLK;GNB2L1;CD72;EPHX2;GRIN2A;ARPP19;NRG2;CXCL10;GFRA1
syntaxin bindingSYT7;VPS52;VPS54;CPLX3A;TXLNG;SYT7B;NAPAB;TXLNBB;TMED10

ABL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABL1.

ABI1; MSH5

Murray, JC; Aldeghaither, D; et al. c-Abl Modulates Tumor Cell Sensitivity to Antibody-Dependent Cellular Cytotoxicity. CANCER IMMUNOLOGY RESEARCH 2:1186-1198(2014).
Krause, DS; Lazarides, K; et al. Selectins and their ligands are required for homing and engraftment of BCR-ABL1(+) leukemic stem cells in the bone marrow niche. BLOOD 123:1361-1371(2014).
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