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ABR

  • Official Full Name

    active BCR-related gene

  • Overview

    This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis, suggesting that Rho-related GTPases help coordinate motor skills and balance. Alternatively spliced transcript variants that encode different isoforms have been reported for this gene.
  • Synonyms

    ABR; active BCR-related gene; active breakpoint cluster region-related protein; MDB; Active BCR related gene; Active breakpoint cluster region related protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Human
  • Mouse
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ABR-115H Recombinant Human ABR Protein, GST-Tagged Wheat Germ GST
Human ABR-116H Recombinant Human ABR Protein, GST-Tagged Wheat Germ GST
Human ABR-9122HCL Recombinant Human ABR 293 Cell Lysate HEK293 N/A
Human ABR-5357H Recombinant Human ABR Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ABR-301435H Recombinant Human ABR protein, GST-tagged E.coli GST Met1-Lys87
Human ABR-835HF Recombinant Full Length Human ABR Protein, GST-tagged In Vitro Cell Free System GST 859 amino acids
Mouse ABR-1148M Recombinant Mouse ABR Protein Mammalian Cell His
Mouse Abr-445M Recombinant Mouse Abr Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ABR-226M Recombinant Mouse ABR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ABR-226M-B Recombinant Mouse ABR Protein Pre-coupled Magnetic Beads HEK293
Bovine ABR-3116B Recombinant Bovine ABR, His-tagged E.Coli or Yeast His 859
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ABR Related Articles

ABR involved in several pathways and played different roles in them. We selected most pathways ABR participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G alpha (12/13) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell death signalling via NRAGE, NRIF and NADEFGD4;BCL2L11;DCLRE1B;KALRN;ITSN1;TIAM2;AKAP13;ITGB3BP;KALRNB
G alpha (12/13) signalling eventsFGD2;AKAP13;ITSN1;ARHGEF18A;RHOC;ARHGAP4A;GNA13;DCLRE1B;GNA13B
GPCR downstream signalingMLN;ARHGEF18;RAMP1;CHRM1;ARHGEF25;PNOCB;CCR8;QRFP;OXGR1A.2
NRAGE signals death through JNKTIAM2;ABR;OBSCN;ARHGEF16;ARHGEF18A;ECT2;ARHGEF9;FGD2;ARHGEF1A
Regulation of RAC1 activityARHGAP1;RAP1GDS1;RALBP1;DOCK6;ARHGAP17;PREX2;DEF6;ABR;ARHGEF25
Regulation of RhoA activityNET1;OBSCN;ARHGEF10L;PLEKHG6;ABR;ARHGEF18;AKAP13;FARP1;ARHGEF25
Rho GTPase cycleDEPDC1B;ARHGEF1A;ARHGAP19;RHOU;DLC1;ECT2;ARHGAP17;RHOT1A;ARHGAP26
Signal TransductionCBY1;GDI1;RPGRIP1L;LRIG1;DACT1;RDH14A;RLN3;RHOUA;ARHGAP17A

ABR has several biochemical functions, for example, GTPase activator activity, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABR itself. We selected most functions ABR had, and list some proteins which have the same functions with ABR. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityRGS18;RAP1GAP2A;NIPAL1;ARHGAP12;ARHGAP42;RAP1GDS1;ARAP2;ERRFI1;IQGAP3
Rho guanyl-nucleotide exchange factor activityTRIOA;ARHGEF10L;DCLRE1B;FLJ20184;KALRNB;DOCK9;OBSCN;ARHGEF16;DOCK10

ABR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABR here. Most of them are supplied by our site. Hope this information will be useful for your research of ABR.

Dlg4; ABL1; ADRA1A; pi3p

Kavakli, K; Yang, R; et al. Prophylaxis vs. on-demand treatment with BAY 81-8973, a full-length plasma protein-free recombinant factor VIII product: results from a randomized trial (LEOPOLD II). JOURNAL OF THROMBOSIS AND HAEMOSTASIS 13:360-369(2015).
Urasinski, T; Stasyshyn, O; et al. Recombinant factor IX (BAX326(1)) in previously treated paediatric patients with haemophilia B: a prospective clinical trial. HAEMOPHILIA 21:196-203(2015).
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