ACADVL
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Official Full Name
acyl-CoA dehydrogenase, very long chain
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Overview
The protein encoded by this gene is targeted to the inner mitochondrial membrane where it catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. This acyl-Coenzyme A dehydrogenase is specific to long-chain and very-long-chain fatty acids. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
ACADVL; acyl-CoA dehydrogenase, very long chain; acyl Coenzyme A dehydrogenase, very long chain; very long-chain specific acyl-CoA dehydrogenase, mitochondrial; ACAD6; LCACD; VLCAD; acyl-Coenzyme A dehydrogenase, very long chain;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- MYC
- DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ACADVL-9271H | Recombinant Human ACADVL, His-tagged | E.coli | His | 312-655a.a. | |
Human | ACADVL-138H | Recombinant Human ACADVL Protein, GST-Tagged | Wheat Germ | GST | ||
Human | ACADVL-785H | Recombinant Human ACADVL, His-tagged | E.coli | His | ||
Human | ACADVL-26050TH | Recombinant Human ACADVL, His-tagged | E.coli | His | 615 amino acids | |
Human | ACADVL-139H | Recombinant Human ACADVL Protein, GST-Tagged | Wheat Germ | GST | ||
Human | ACADVL-9111HCL | Recombinant Human ACADVL 293 Cell Lysate | HEK293 | N/A | ||
Human | ACADVL-911HF | Recombinant Full Length Human ACADVL Protein, GST-tagged | In Vitro Cell Free System | GST | 655 amino acids | |
Human | ACADVL-27H | Recombinant Human ACADVL Protein, His-tagged | E.coli | N-His | Ala408-Phe655 | |
Mouse | Acadvl-28M | Recombinant Mouse Acadvl Protein, His-tagged | E.coli | N-His | Ile421-Ile656 | |
Mouse | Acadvl-504M | Recombinant Mouse Acadvl Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Rat | ACADVL-440R | Recombinant Rat ACADVL Protein | Mammalian Cell | His | ||
Rat | ACADVL-95R | Recombinant Rat ACADVL Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | ACADVL-95R-B | Recombinant Rat ACADVL Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | ACADVL-11890Z | Recombinant Zebrafish ACADVL | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- ACADVL Related Articles
ACADVL involved in several pathways and played different roles in them. We selected most pathways ACADVL participated on our site, such as Fatty acid degradation, Metabolic pathways, Fatty acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACADVL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Fatty acid degradation | HADHAB;CPT1C;ACSL3;ACAT2;ADH4;EHHADH;ALDH2;ADH1;CYP4A12A |
Metabolic pathways | SAT1A.1;G6PCA.1;AUH;ATP6V1G1;GCSHB;PTGS2B;CSAD;ALDH7A1;B4GALT7 |
Fatty acid metabolism | HSD17B12B;ACSBG2;ACSL1B;ACSL3A;ACSL1A;HADH;TECR;PPT2;ACOX3 |
ACADVL has several biochemical functions, for example, acyl-CoA dehydrogenase activity, electron carrier activity, fatty-acyl-CoA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACADVL itself. We selected most functions ACADVL had, and list some proteins which have the same functions with ACADVL. You can find most of the proteins on our site.
Function | Related Protein |
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acyl-CoA dehydrogenase activity | ACOX2;ETFA;ACAD8;ACADS;ACADL;ACAD9;ACADSB;ACADVL;ACOX3 |
electron carrier activity | DERL3;AOX3;IVD;COX7A1;IDH3B;AKR7A2;TXNRD1;COX11;AKR1B1 |
fatty-acyl-CoA binding | ACADSB;ECI2;DBIL5;HMGCL;GCDHB;ETFA;ACOT7;HADHA;ACADS |
flavin adenine dinucleotide binding | MAOA;GULO;FMO1;ACADM;FMO5;CHDH;ETFA;LDHD;GCDH |
long-chain-acyl-CoA dehydrogenase activity | ACADL;ACADVL;ACAD11 |
oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor | ACOX1;GCDH;ACOXL;ACADL;ACADM;ACADVL;ACAD11;IVD;ACADSB |
very-long-chain-acyl-CoA dehydrogenase activity | ACADVL;RSAD1;ACAD11 |
ACADVL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACADVL here. Most of them are supplied by our site. Hope this information will be useful for your research of ACADVL.
CDH1; RPSA; GPHN; KIF2A; EEF2K; DENR; ALB; CDK1; ATF2; EIF4A3; METAP2; CKAP5; ICT1; Ncbp2; PA2G4; SIRT4
- Q&As
- Reviews
Q&As (10)
Ask a questionThe recombinant ACADVL protein can be used in various applications, such as enzyme assays, drug screening, and protein-protein interaction studies.
The recommended usage guidelines can vary depending on the specific application, but typically involve optimizing the protein concentration, buffer conditions, and other experimental parameters.
Sure, ACADVL has been suggested as a potential biomarker for various diseases, including non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
ACADVL deficiency reduces myocardial fatty acid β-oxidation and is associated with cardiomyopathy. In addition, very long-chain acyl-CoA dehydrogenase deficiency is a rare, life-threatening disorder of mitochondrial fatty acid oxidation metabolism caused by mutations in the ACADVL gene.
Mutations in the ACADVL gene can lead to VLCADD, a rare inherited disorder that affects the metabolism of VLCFAs. Symptoms of VLCADD can include muscle weakness, lethargy, and hypoglycemia. A recent study investigated the impact of ACADVL deficiency on mitochondrial function and found that it leads to impaired fatty acid oxidation and increased oxidative stress.
These quality control measures can include testing for purity, concentration, and functionality, as well as ensuring the protein is free from contaminants, such as endotoxins or microbial contaminants.
Sure, you can describe the specific mutation site in the online form, and our scientists will tailor the corresponding protein products for you.
ACADVL has been implicated in several lipid metabolic pathways, including the beta-oxidation of fatty acids, the biosynthesis of unsaturated fatty acids, and the synthesis of ether lipids.
You can submit specific requirements, and our experts will contact you.
Our high-purity recombinant proteins are suitable for biophysics-related research, such as structural elucidation, molecular dynamics simulations, and interaction studies.
Customer Reviews (3)
Write a reviewI was very impressed with the customized recombinant protein that Creative BioMart created for me. The technical support experts were extremely helpful and accommodating, and the product exceeded my expectations.
I have been consistently impressed with the quality and purity of Creative BioMart's recombinant ACADVL proteins. Their products are reliable and cost-effective, and I plan to repurchase from them in the future.
Thanks to Creative BioMart's ACADVL recombinant protein, I was able to save a significant amount of time on my project. The product was of high quality and reasonably priced.
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