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ACADVL

  • Official Full Name

    acyl-CoA dehydrogenase, very long chain

  • Overview

    The protein encoded by this gene is targeted to the inner mitochondrial membrane where it catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. This acyl-Coenzyme A dehydrogenase is specific to long-chain and very-long-chain fatty acids. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms

    ACADVL; acyl-CoA dehydrogenase, very long chain; acyl Coenzyme A dehydrogenase, very long chain; very long-chain specific acyl-CoA dehydrogenase, mitochondrial; ACAD6; LCACD; VLCAD; acyl-Coenzyme A dehydrogenase, very long chain;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACADVL-9271H Recombinant Human ACADVL, His-tagged E.coli His 312-655a.a.
Human ACADVL-138H Recombinant Human ACADVL Protein, GST-Tagged Wheat Germ GST
Human ACADVL-785H Recombinant Human ACADVL, His-tagged E.coli His
Human ACADVL-26050TH Recombinant Human ACADVL, His-tagged E.coli His 615 amino acids
Human ACADVL-139H Recombinant Human ACADVL Protein, GST-Tagged Wheat Germ GST
Human ACADVL-9111HCL Recombinant Human ACADVL 293 Cell Lysate HEK293 N/A
Human ACADVL-911HF Recombinant Full Length Human ACADVL Protein, GST-tagged In Vitro Cell Free System GST 655 amino acids
Human ACADVL-27H Recombinant Human ACADVL Protein, His-tagged E.coli N-His Ala408-Phe655
Mouse Acadvl-28M Recombinant Mouse Acadvl Protein, His-tagged E.coli N-His Ile421-Ile656
Mouse Acadvl-504M Recombinant Mouse Acadvl Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat ACADVL-440R Recombinant Rat ACADVL Protein Mammalian Cell His
Rat ACADVL-95R Recombinant Rat ACADVL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ACADVL-95R-B Recombinant Rat ACADVL Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ACADVL-11890Z Recombinant Zebrafish ACADVL Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ACADVL Related Articles

ACADVL involved in several pathways and played different roles in them. We selected most pathways ACADVL participated on our site, such as Fatty acid degradation, Metabolic pathways, Fatty acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACADVL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fatty acid degradationHADHAB;CPT1C;ACSL3;ACAT2;ADH4;EHHADH;ALDH2;ADH1;CYP4A12A
Metabolic pathwaysSAT1A.1;G6PCA.1;AUH;ATP6V1G1;GCSHB;PTGS2B;CSAD;ALDH7A1;B4GALT7
Fatty acid metabolismHSD17B12B;ACSBG2;ACSL1B;ACSL3A;ACSL1A;HADH;TECR;PPT2;ACOX3

ACADVL has several biochemical functions, for example, acyl-CoA dehydrogenase activity, electron carrier activity, fatty-acyl-CoA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACADVL itself. We selected most functions ACADVL had, and list some proteins which have the same functions with ACADVL. You can find most of the proteins on our site.

Function Related Protein
acyl-CoA dehydrogenase activityACOX2;ETFA;ACAD8;ACADS;ACADL;ACAD9;ACADSB;ACADVL;ACOX3
electron carrier activityDERL3;AOX3;IVD;COX7A1;IDH3B;AKR7A2;TXNRD1;COX11;AKR1B1
fatty-acyl-CoA bindingACADSB;ECI2;DBIL5;HMGCL;GCDHB;ETFA;ACOT7;HADHA;ACADS
flavin adenine dinucleotide bindingMAOA;GULO;FMO1;ACADM;FMO5;CHDH;ETFA;LDHD;GCDH
long-chain-acyl-CoA dehydrogenase activityACADL;ACADVL;ACAD11
oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptorACOX1;GCDH;ACOXL;ACADL;ACADM;ACADVL;ACAD11;IVD;ACADSB
very-long-chain-acyl-CoA dehydrogenase activityACADVL;RSAD1;ACAD11

ACADVL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACADVL here. Most of them are supplied by our site. Hope this information will be useful for your research of ACADVL.

CDH1; RPSA; GPHN; KIF2A; EEF2K; DENR; ALB; CDK1; ATF2; EIF4A3; METAP2; CKAP5; ICT1; Ncbp2; PA2G4; SIRT4

Kabuyama, Y; Suzuki, T; et al. Dysregulation of very long chain acyl-CoA dehydrogenase coupled with lipid peroxidation. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 298:C107-C113(2010).
Merrittll, JL; Nguyen, T; et al. Biochemical Correction of Very Long-chain Acyl-CoA Dehydrogenase Deficiency Following Adeno-associated Virus Gene Therapy. MOLECULAR THERAPY 17:425-429(2009).
  • Q&As
  • Reviews

Q&As (10)

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What are the applications of the recombinant ACADVL protein? 11/26/2022

The recombinant ACADVL protein can be used in various applications, such as enzyme assays, drug screening, and protein-protein interaction studies.

What are the recommended usage guidelines of your recombinant ACADVL protein? 09/15/2022

The recommended usage guidelines can vary depending on the specific application, but typically involve optimizing the protein concentration, buffer conditions, and other experimental parameters.

Can your recombinant ACADVL protein be used in biomarker research? 08/24/2022

Sure, ACADVL has been suggested as a potential biomarker for various diseases, including non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.

What diseases can be caused by abnormal expression of ACADVL? 04/05/2022

ACADVL deficiency reduces myocardial fatty acid β-oxidation and is associated with cardiomyopathy. In addition, very long-chain acyl-CoA dehydrogenase deficiency is a rare, life-threatening disorder of mitochondrial fatty acid oxidation metabolism caused by mutations in the ACADVL gene.

How is ACADVL implicated in disease, and what are some potential therapeutic targets? 01/25/2022

Mutations in the ACADVL gene can lead to VLCADD, a rare inherited disorder that affects the metabolism of VLCFAs. Symptoms of VLCADD can include muscle weakness, lethargy, and hypoglycemia. A recent study investigated the impact of ACADVL deficiency on mitochondrial function and found that it leads to impaired fatty acid oxidation and increased oxidative stress.

What quality control measures are in place to ensure the recombinant ACADVL protein is of high quality? 12/27/2021

These quality control measures can include testing for purity, concentration, and functionality, as well as ensuring the protein is free from contaminants, such as endotoxins or microbial contaminants.

Can you customize recombinant proteins with potential hotspot ACADVL mutations? 05/06/2020

Sure, you can describe the specific mutation site in the online form, and our scientists will tailor the corresponding protein products for you.

What is the role of ACADVL in lipid metabolism? 04/30/2020

ACADVL has been implicated in several lipid metabolic pathways, including the beta-oxidation of fatty acids, the biosynthesis of unsaturated fatty acids, and the synthesis of ether lipids.

Do you have commercial antibodies for ACADVL? 04/18/2020

You can submit specific requirements, and our experts will contact you.

Can your recombinant ACADVL protein be used for structural studies? 01/31/2020

Our high-purity recombinant proteins are suitable for biophysics-related research, such as structural elucidation, molecular dynamics simulations, and interaction studies.

Customer Reviews (3)

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Reviews
09/15/2022

    I was very impressed with the customized recombinant protein that Creative BioMart created for me. The technical support experts were extremely helpful and accommodating, and the product exceeded my expectations.

    05/08/2021

      I have been consistently impressed with the quality and purity of Creative BioMart's recombinant ACADVL proteins. Their products are reliable and cost-effective, and I plan to repurchase from them in the future.

      01/16/2020

        Thanks to Creative BioMart's ACADVL recombinant protein, I was able to save a significant amount of time on my project. The product was of high quality and reasonably priced.

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