ACAT2
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Official Full Name
acetyl-CoA acetyltransferase 2
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Overview
The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. [provided by RefSeq, Jul 2008] -
Synonyms
ACAT2; acetyl-CoA acetyltransferase 2; acetyl-CoA acetyltransferase, cytosolic; acetoacetyl Coenzyme A thiolase; cytosolic acetoacetyl-CoA thiolase; acetyl-CoA transferase-like protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- His|T7
- DDK
- N/A
- N
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- ACAT2 Related Articles
ACAT2 involved in several pathways and played different roles in them. We selected most pathways ACAT2 participated on our site, such as Fatty acid degradation, Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Fatty acid degradation | CPT1C;ALDH2.2;ADH5;ACSBG2;ADH7;CPT1A;ALDH9A1;ALDH9A1B;ALDH9A1A.1 |
Synthesis and degradation of ketone bodies | OXCT2B;HMGCS2;OXCT2A;OXCT2;HMGCLL1;OXCT1A;OXCT1;HMGCS1;ACAT1 |
Valine, leucine and isoleucine degradation | IL4I1;MCEE;HADHA;ACAT1;OXCT2B;MCCC1;HADHAB;ACAA1A;ALDH3A2 |
Lysine degradation | ALDH9A1B;ALDH9A1A.1;HYKK;DOT1L;ALDH1B1;SUV39H1B;SETDB2;PLOD2;SETD1B |
Tryptophan metabolism | IL4I1;AOX4;ALDH7A1;ALDH9A1;HAAO;OGDHA;HADHAB;ALDH2.1;AADAT |
Pyruvate metabolism | MPC1;ALDH9A1A.1;PC;PDK3;ALDH1B1;ALDH7A1;DLAT;ALDH9A1;ALDH3A2A |
Glyoxylate and dicarboxylate metabolism | AGXTA;GCSH;CAT;ACO2;HAO2;GLUL;MCEE;HOGA1;GLYCTK |
Propanoate metabolism | LDHC;BCKDHB;ackA;HIBCH;MUT;ACAT1;ALDH6A1;LDHBB;MLYCD |
Butanoate metabolism | ECHS1;HADH;HMGCL;ACSM5;ACADS;ALDH5A1;ACSM1;ACAT2;HADHAA |
Terpenoid backbone biosynthesis | PDSS1;ACAT1;HMGCRB;PMVK;DHDDS;MVK;NUS1;ICMT;HMGCR |
Metabolic pathways | CCBL1;ACSL1A;HSD17B12;NDUFC1;PGAM1A;NDUFAB1;UQCR11;IMPDH1B;AKR1B10 |
Carbon metabolism | ALDOAB;G6PD;PFKL;OGDHA;PDHA1B;EHHADH;ENO1;PC;TKTB |
Fatty acid metabolism | HSD17B12B;ACSL1;MCAT;ACSL5;ELOVL2;EHHADH;CPT1A;CPT1B;ACADL |
Fat digestion and absorption | PLA2G12A;MOGAT3;SLC27A4;DGAT2;ACAT2;PLA2G2D;GOT2;LIPF;MOGAT2 |
ACAT2 has several biochemical functions, for example, acetyl-CoA C-acetyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACAT2 itself. We selected most functions ACAT2 had, and list some proteins which have the same functions with ACAT2. You can find most of the proteins on our site.
Function | Related Protein |
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acetyl-CoA C-acetyltransferase activity | ACAT2;ACAT1;ACAA1A;HADHA |
protein binding | PREP;ARHGEF15;MBNL3;CUL2;SMU1;PECAM1;SWSAP1;PLK4;ASB13 |
ACAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACAT2.
LNX1; TERF1; EIF1B; VDAC1; MCC; HLA-B; GNAS; CCNA1; ATG5; FTSJ1; TNIK; PRKAB1; TRAF6
- Q&As
- Reviews
Q&As (10)
Ask a questionTypically, protein purity is measured using techniques such as SDS-PAGE, Western blotting, or HPLC.
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Creative BioMart uses a variety of quality control measures to ensure the purity, identity, and activity of our products. These may include analytical testing such as SDS-PAGE, Western blotting, and ELISA, as well as functional assays to confirm activity. We can also perform endotoxin testing or use other methods to ensure the product is free from contaminants.
Like all proteins, recombinant ACAT2 protein should be handled with appropriate safety precautions, such as wearing gloves and avoiding direct contact with skin or mucous membranes. It is also important to follow good laboratory practices and to dispose of any waste materials properly.
The recommended concentration and volume of recombinant ACAT2 protein can vary depending on the specific assay or experiment being performed. Typically, the protein is dissolved in a buffer solution at a desired concentration (e.g. 0.1-1 mg/mL) and then used as needed. It is important to ensure that the protein concentration is appropriate for the intended use, as high concentrations may result in nonspecific binding or other issues.
Recombinant ACAT2 protein can be used in a variety of research applications, including studying the function of ACAT2 in lipid metabolism and cholesterol homeostasis, as well as in drug discovery efforts related to cardiovascular disease, obesity, and other metabolic disorders. It may also be used as a reference or standard in diagnostic tests for certain diseases.
The expression and activity of ACAT2 are regulated by a variety of factors, including dietary cholesterol intake, hormonal signals, and transcriptional and post-transcriptional mechanisms. Studies have identified several transcription factors that bind to the ACAT2 promoter region and regulate its expression, as well as post-transcriptional mechanisms such as alternative splicing and miRNA-mediated regulation.
In addition to recombinant ACAT2 protein, there may be natural sources of ACAT2 protein, such as from animal or human tissues. However, these sources may be more difficult to obtain and may have variable purity or activity. It is important to evaluate the quality and activity of these alternative sources before use in experiments or assays.
Inhibition of ACAT2 has been proposed as a potential therapeutic strategy for the treatment of cardiovascular disease, as well as other metabolic disorders such as nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes. Several small molecule inhibitors of ACAT2 have been developed and are currently undergoing preclinical and clinical evaluation.
ACAT2 is a key enzyme involved in the conversion of free cholesterol to cholesterol esters, which are stored in lipid droplets in cells. Dysregulation of ACAT2 activity has been implicated in the development of atherosclerosis and other metabolic disorders. Studies have shown that inhibition of ACAT2 can reduce atherosclerotic plaque formation in animal models, suggesting that ACAT2 may be a potential therapeutic target for the prevention and treatment of cardiovascular disease.
Customer Reviews (3)
Write a reviewThe purity and quality of Creative BioMart's recombinant human ACAT2 protein is unmatched. I have tried other protein products in the past, but this one is by far the best.
The recombinant human ACAT2 protein is of high quality and purity, and it has worked perfectly in my experiments.
The recombinant human ACAT2 protein from Creative BioMart is highly pure and stable, and I have had great success using it in my assays.
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