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ACAT2

  • Official Full Name

    acetyl-CoA acetyltransferase 2

  • Overview

    The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. [provided by RefSeq, Jul 2008]
  • Synonyms

    ACAT2; acetyl-CoA acetyltransferase 2; acetyl-CoA acetyltransferase, cytosolic; acetoacetyl Coenzyme A thiolase; cytosolic acetoacetyl-CoA thiolase; acetyl-CoA transferase-like protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|T7
  • DDK
  • N/A
  • N
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACAT2-144H Recombinant Human ACAT2 Protein, GST-Tagged Wheat Germ GST
Human ACAT2-9277H Recombinant Human ACAT2, GST-tagged E.coli GST 1-397a.a.
Human ACAT2-29H Recombinant Human ACAT2, T7-tagged E.coli T7
Human ACAT2-776H Recombinant Human ACAT2, His-tagged E.coli His
Human ACAT2-26052TH Recombinant Human ACAT2, T7 -tagged E.coli T7
Human ACAT2-166H Recombinant Human ACAT2 protein, T7-tagged E.coli T7
Human ACAT2-9108HCL Recombinant Human ACAT2 293 Cell Lysate HEK293 N/A
Human ACAT2-4673H Recombinant Human ACAT2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ACAT2-1055HFL Recombinant Full Length Human ACAT2 Protein, C-Flag-tagged Mammalian cells Flag
Human ACAT2-491H Recombinant Human ACAT2 protein, His&Myc-tagged E.coli His&Myc 1-397aa
Human ACAT2-0178H Recombinant Human ACAT2 Protein (Met1-Glu397), N-His-tagged E.coli N-His Met1-Glu397
Human ACAT2-253H-B Recombinant Human ACAT2 Protein Pre-coupled Magnetic Beads HEK293
Human ACAT2-253H Recombinant Human ACAT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Acat2-8160M Recombinant Mouse Acat2 protein, His & T7-tagged E.coli His/T7 Met1~Gly397 (Accession # Q8CAY6)
Mouse ACAT2-1170M Recombinant Mouse ACAT2 Protein Mammalian Cell His
Mouse ACAT2-244M-B Recombinant Mouse ACAT2 Protein Pre-coupled Magnetic Beads HEK293
Mouse ACAT2-244M Recombinant Mouse ACAT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Acat2-291E Recombinant Rat Acat2 protein(Met1-Gly397), His-tagged E. coli N-His Met1-Gly397
Zebrafish ACAT2-8947Z Recombinant Zebrafish ACAT2 Mammalian Cell His
Chicken ACAT2-3348C Recombinant Chicken ACAT2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ACAT2 Related Articles

ACAT2 involved in several pathways and played different roles in them. We selected most pathways ACAT2 participated on our site, such as Fatty acid degradation, Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fatty acid degradationCPT1C;ALDH2.2;ADH5;ACSBG2;ADH7;CPT1A;ALDH9A1;ALDH9A1B;ALDH9A1A.1
Synthesis and degradation of ketone bodiesOXCT2B;HMGCS2;OXCT2A;OXCT2;HMGCLL1;OXCT1A;OXCT1;HMGCS1;ACAT1
Valine, leucine and isoleucine degradationIL4I1;MCEE;HADHA;ACAT1;OXCT2B;MCCC1;HADHAB;ACAA1A;ALDH3A2
Lysine degradationALDH9A1B;ALDH9A1A.1;HYKK;DOT1L;ALDH1B1;SUV39H1B;SETDB2;PLOD2;SETD1B
Tryptophan metabolismIL4I1;AOX4;ALDH7A1;ALDH9A1;HAAO;OGDHA;HADHAB;ALDH2.1;AADAT
Pyruvate metabolismMPC1;ALDH9A1A.1;PC;PDK3;ALDH1B1;ALDH7A1;DLAT;ALDH9A1;ALDH3A2A
Glyoxylate and dicarboxylate metabolismAGXTA;GCSH;CAT;ACO2;HAO2;GLUL;MCEE;HOGA1;GLYCTK
Propanoate metabolismLDHC;BCKDHB;ackA;HIBCH;MUT;ACAT1;ALDH6A1;LDHBB;MLYCD
Butanoate metabolismECHS1;HADH;HMGCL;ACSM5;ACADS;ALDH5A1;ACSM1;ACAT2;HADHAA
Terpenoid backbone biosynthesisPDSS1;ACAT1;HMGCRB;PMVK;DHDDS;MVK;NUS1;ICMT;HMGCR
Metabolic pathwaysCCBL1;ACSL1A;HSD17B12;NDUFC1;PGAM1A;NDUFAB1;UQCR11;IMPDH1B;AKR1B10
Carbon metabolismALDOAB;G6PD;PFKL;OGDHA;PDHA1B;EHHADH;ENO1;PC;TKTB
Fatty acid metabolismHSD17B12B;ACSL1;MCAT;ACSL5;ELOVL2;EHHADH;CPT1A;CPT1B;ACADL
Fat digestion and absorptionPLA2G12A;MOGAT3;SLC27A4;DGAT2;ACAT2;PLA2G2D;GOT2;LIPF;MOGAT2

ACAT2 has several biochemical functions, for example, acetyl-CoA C-acetyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACAT2 itself. We selected most functions ACAT2 had, and list some proteins which have the same functions with ACAT2. You can find most of the proteins on our site.

Function Related Protein
acetyl-CoA C-acetyltransferase activityACAT2;ACAT1;ACAA1A;HADHA
protein bindingPREP;ARHGEF15;MBNL3;CUL2;SMU1;PECAM1;SWSAP1;PLK4;ASB13

ACAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACAT2.

LNX1; TERF1; EIF1B; VDAC1; MCC; HLA-B; GNAS; CCNA1; ATG5; FTSJ1; TNIK; PRKAB1; TRAF6

Sakashita, N; Miyazaki, A; et al. Acyl-coenzyme A : cholesterol acyltransferase 2 (ACAT2) is induced in monocyte-derived macrophages: In vivo and in vitro studies. LABORATORY INVESTIGATION 83:1569-1581(2003).
Lin, S; Lu, XH; et al. Human acyl-coenzyme A : cholesterol acyltransferase expressed in Chinese hamster ovary cells: Membrane topology and active site location. MOLECULAR BIOLOGY OF THE CELL 14:2447-2460(2003).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
How to measure the purity of recombinant ACAT2 protein? 02/05/2023

Typically, protein purity is measured using techniques such as SDS-PAGE, Western blotting, or HPLC.

Is there any discount for recombinant human ACAT2 protein (ACAT2-144H)? 12/23/2022

We are offering a 10% discount on all products for a limited time. The clock is ticking down. Be sure to take advantage of our holiday promotions!

How is the quality of recombinant ACAT2 protein ensured? 12/12/2022

Creative BioMart uses a variety of quality control measures to ensure the purity, identity, and activity of our products. These may include analytical testing such as SDS-PAGE, Western blotting, and ELISA, as well as functional assays to confirm activity. We can also perform endotoxin testing or use other methods to ensure the product is free from contaminants.

Are there any precautions or safety concerns to be aware of when working with recombinant ACAT2 protein? 03/14/2022

Like all proteins, recombinant ACAT2 protein should be handled with appropriate safety precautions, such as wearing gloves and avoiding direct contact with skin or mucous membranes. It is also important to follow good laboratory practices and to dispose of any waste materials properly.

What is the recommended concentration and volume of recombinant ACAT2 protein for use in assays or experiments? 02/21/2022

The recommended concentration and volume of recombinant ACAT2 protein can vary depending on the specific assay or experiment being performed. Typically, the protein is dissolved in a buffer solution at a desired concentration (e.g. 0.1-1 mg/mL) and then used as needed. It is important to ensure that the protein concentration is appropriate for the intended use, as high concentrations may result in nonspecific binding or other issues.

What are the potential applications of recombinant ACAT2 protein? 12/12/2021

Recombinant ACAT2 protein can be used in a variety of research applications, including studying the function of ACAT2 in lipid metabolism and cholesterol homeostasis, as well as in drug discovery efforts related to cardiovascular disease, obesity, and other metabolic disorders. It may also be used as a reference or standard in diagnostic tests for certain diseases.

How are the expression and activity of ACAT2 regulated in the body? 08/22/2021

The expression and activity of ACAT2 are regulated by a variety of factors, including dietary cholesterol intake, hormonal signals, and transcriptional and post-transcriptional mechanisms. Studies have identified several transcription factors that bind to the ACAT2 promoter region and regulate its expression, as well as post-transcriptional mechanisms such as alternative splicing and miRNA-mediated regulation.

Are there any alternative sources of ACAT2 protein, such as natural sources? 03/17/2021

In addition to recombinant ACAT2 protein, there may be natural sources of ACAT2 protein, such as from animal or human tissues. However, these sources may be more difficult to obtain and may have variable purity or activity. It is important to evaluate the quality and activity of these alternative sources before use in experiments or assays.

What are the potential therapeutic applications of targeting ACAT2? 10/12/2020

Inhibition of ACAT2 has been proposed as a potential therapeutic strategy for the treatment of cardiovascular disease, as well as other metabolic disorders such as nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes. Several small molecule inhibitors of ACAT2 have been developed and are currently undergoing preclinical and clinical evaluation.

What is the role of ACAT2 in lipid metabolism and its association with atherosclerosis? 09/18/2020

ACAT2 is a key enzyme involved in the conversion of free cholesterol to cholesterol esters, which are stored in lipid droplets in cells. Dysregulation of ACAT2 activity has been implicated in the development of atherosclerosis and other metabolic disorders. Studies have shown that inhibition of ACAT2 can reduce atherosclerotic plaque formation in animal models, suggesting that ACAT2 may be a potential therapeutic target for the prevention and treatment of cardiovascular disease.

Customer Reviews (3)

Write a review
Reviews
01/02/2023

    The purity and quality of Creative BioMart's recombinant human ACAT2 protein is unmatched. I have tried other protein products in the past, but this one is by far the best.

    12/12/2022

      The recombinant human ACAT2 protein is of high quality and purity, and it has worked perfectly in my experiments.

      12/12/2021

        The recombinant human ACAT2 protein from Creative BioMart is highly pure and stable, and I have had great success using it in my assays.

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