ACO2
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Official Full Name
aconitase 2, mitochondrial
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Overview
Aconitase 2 (ACO2) catalyzes the conversion of citrate to isocitrate via cis-aconitate in the second step of the tricarboxylic acid (TCA) cycle. ACO2 also is an important regulator of iron homeostasis within cells. In addition, this enzyme is found to be -
Synonyms
ACO2; aconitase 2, mitochondrial; aconitate hydratase, mitochondrial; ACONM; citrate hydro-lyase; ICRD; MGC20605; MGC33908;
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- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ACO2 Related Articles
ACO2 involved in several pathways and played different roles in them. We selected most pathways ACO2 participated on our site, such as Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Citrate cycle (TCA cycle) | ACO1;PCK1;OGDHL;PDHA1A;FH1;DLD;DLDH;PCXB;MDH1 |
| Glyoxylate and dicarboxylate metabolism | CS;GRHPRB;DLDH;ACO1;GLULA;GCSH;GCSHB;HAO1;SHMT1 |
| Metabolic pathways | MTMR7;DHRS4L2;PLA2G4D;DNMT3A;RDH8;PLA2G12B;GCLM;PON1;PCYT1AA |
| Carbon metabolism | ME2;GPT2;CAT;AGXTB;HK3;GPIA;TPI1;MDH2;PRPS1 |
| -Oxocarboxylic acid metabolism | BCAT2;BCAT1;GPT2L;ACO2;GOT1;AADAT;GOT2B;IDH2;GOT2 |
| Biosynthesis of amino acids | PGK2;ALDH18A1;GOT2;ENO1;PYCR2;pykF;ALDH7A1;PYCRL;SHMT2 |
ACO2 has several biochemical functions, for example, 3 iron, 4 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, aconitate hydratase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACO2 itself. We selected most functions ACO2 had, and list some proteins which have the same functions with ACO2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3 iron, 4 sulfur cluster binding | SDHB;ACO2 |
| 4 iron, 4 sulfur cluster binding | NDUFS1;ETFDH;POLE;LIAS;RSAD1;NUBP2;NUBPL;NFU1;DEM1 |
| aconitate hydratase activity | ACO1;ACO2 |
| iron ion binding | FAXDC2;EGLN1;ALOX5B.2;TPH1A;P4HTM;CYP4V8;HBBE2;HBB-B2;CALR |
ACO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACO2.
VCAM1; MLH1; ere_dna; CLPP
- Q&As
- Reviews
Q&As (10)
Ask a questionACO2 is involved in the TCA cycle, which is a critical process for energy production in cells. Specifically, it catalyzes the conversion of citrate to isocitrate, which is a crucial step in the cycle.
Yes, mutations in the ACO2 gene have been associated with several disorders, including infantile cerebellar-retinal degeneration and mitochondrial encephalopathy. These conditions are characterized by a range of symptoms, including neurological and developmental abnormalities.
ACO2 is a potential target for cancer treatment, as it is overexpressed in several types of cancer cells. However, the development of drugs that target ACO2 is still in the early stages of research.
ACO1 and ACO2 are two isoforms of aconitate hydratase, which catalyze the same reaction in the TCA cycle. However, ACO2 is primarily located in the mitochondria of cells, while ACO1 is located in the cytoplasm.
Unlike ACO1, ACO2 is not involved in iron metabolism. Its role is primarily in energy production through the TCA cycle.
ACO2 deficiency has been associated with several disorders, including infantile cerebellar-retinal degeneration and mitochondrial encephalopathy. These conditions are characterized by various neurological and developmental abnormalities.
ACO2 is a homodimeric enzyme composed of two identical subunits. Each subunit contains a catalytic domain and a regulatory domain, which work together to catalyze the isomerization of citrate to isocitrate.
ACO2 activity can be measured in the laboratory using a variety of techniques, including spectrophotometric assays and enzymatic activity assays. These assays typically involve measuring the rate of citrate isomerization to isocitrate in the presence of ACO2 and other necessary cofactors.
ACO2 activity is regulated by a variety of factors, including substrate availability, pH, and post-translational modifications such as phosphorylation. Additionally, ACO2 activity can be modulated by other enzymes and metabolic pathways in the cell.
While ACO2 is primarily known for its role in energy production, recent research suggests that it may also play a role in other cellular processes. For example, studies have shown that ACO2 may be involved in regulating the immune response and cellular metabolism.
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