ACOT12
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Official Full Name
acyl-CoA thioesterase 12
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Synonyms
ACOT12; acyl-CoA thioesterase 12; acyl-coenzyme A thioesterase 12; Cach; StAR related lipid transfer (START) domain containing 15; STARD15; THEAL; hCACH-1; cytosolic acetyl-CoA hydrolase; acyl-CoA thioester hydrolase 12; START domain-containing protein 15;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ACOT12-9297H | Recombinant Human ACOT12, His-tagged | E.coli | His | 206-555a.a. | |
Human | ACOT12-168H | Recombinant Human ACOT12 Protein, GST-Tagged | Wheat Germ | GST | ||
Human | ACOT12-9090HCL | Recombinant Human ACOT12 293 Cell Lysate | HEK293 | N/A | ||
Human | ACOT12-785HF | Recombinant Full Length Human ACOT12 Protein, GST-tagged | In Vitro Cell Free System | GST | 555 amino acids | |
Human | ACOT12-3440H | Recombinant Human ACOT12 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Mouse | Acot12-1498M | Recombinant Mouse Acot12 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Rat | ACOT12-457R | Recombinant Rat ACOT12 Protein | Mammalian Cell | His | ||
Rat | ACOT12-113R | Recombinant Rat ACOT12 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | ACOT12-113R-B | Recombinant Rat ACOT12 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
- ACOT12 Related Articles
ACOT12 involved in several pathways and played different roles in them. We selected most pathways ACOT12 participated on our site, such as Fatty Acyl-CoA Biosynthesis, Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACOT12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Fatty Acyl-CoA Biosynthesis | ACOT11B;ACSF2;ACOT2;ACOT13;THEM5;ACOT9.2;ACSF3;ACOT11;ACOT7 |
Fatty acid, triacylglycerol, and ketone body metabolism | ACOT11;MED29;ACOT8;ACOT12;CPT2;STIL;ACOT9.2;ACOT9.1;CDK8 |
Metabolism | YAP1;STARD5;CYP2K22;SLC25A15;MOCOS;AMDHD1;ACOT7;SLC25A10;B3GNT1 |
Metabolism of lipids and lipoproteins | CYP11B1;CYP27A1;THEM5;CYP2AD3;AWAT2;MED22;EBP;AWAT1;ACSF3 |
Pyruvate metabolism | GRHPRB;PDHB;PDP1;ACYP1;PKMA;PKM;ALDH2.2;PKM2;PCK1 |
Triglyceride Biosynthesis | ACOT9;ACOT11;Agmo;ACOT13;TMEM195;ACOT6;ACSF3;ACOT7;ACOT11B |
ACOT12 has several biochemical functions, for example, ATP binding, acetyl-CoA hydrolase activity, carboxylic ester hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACOT12 itself. We selected most functions ACOT12 had, and list some proteins which have the same functions with ACOT12. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | MAP2K3;HSPA1B;ABCC9;MYHZ1.1;PDPK1;MYH7;NEK11;PNCK;TDRD12 |
acetyl-CoA hydrolase activity | ACOT9;NUDT7;ACOT12 |
carboxylic ester hydrolase activity | CES2;ABHD2A;ACOT11;ABHD5;FAM135B;Ces2e;ACOT6;ACOT2;BAAT |
lipid binding | S1PR3;FABP12;PAQR7B;SEC14L3;SEC14L4;PFN3;FFAR1;APOA4B.2;PPARA |
ACOT12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACOT12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACOT12.
- Q&As
- Reviews
Q&As (12)
Ask a questionThere are currently no known clinical trials of ACOT12-targeted therapies. However, as this area of research continues to develop, it is possible that clinical trials may be initiated in the future.
The expression of ACOT12 is regulated by various factors, including hormones and nutrients. For example, insulin can upregulate ACOT12 expression in adipose tissue and liver, while fasting can downregulate it. Additionally, dietary factors such as fatty acids and carbohydrates can affect ACOT12 expression in various tissues.
The potential benefits of using ACOT12 protein in drug development include the ability to develop drugs that can regulate lipid metabolism, which can lead to improved treatment options for metabolic disorders such as obesity and diabetes. Additionally, ACOT12 protein can be used as a target for drug discovery, which can lead to the development of new and effective drugs for these conditions.
As with any drug development process, there may be potential risks associated with the use of ACOT12 protein. For example, targeting ACOT12 protein may lead to unintended effects and harm to other metabolic processes. However, these risks can be minimized through careful research, testing, and regulation of drug development.
ACOT12 protein can be produced using recombinant DNA technology in bacteria or mammalian cells. The protein can be purified using various chromatography techniques and verified using assays to ensure its activity and purity.
The potential risks and concerns associated with ACOT12-targeted therapies are not yet fully understood and would depend on the specific targeting strategy used. For example, small molecule inhibitors can have off-target effects and may interact with other drugs, while biologics can have immunogenicity and other safety concerns. Additionally, long-term effects of targeting ACOT12 are still unclear and require further research.
It is possible that ACOT12-targeted therapies could be used as preventive measures for metabolic disorders, especially in at-risk populations. However, more research is needed to determine the optimal timing and dosing of these therapies for maximum benefit.
ACOT12 protein may be used in drug development for metabolic disorders such as obesity and diabetes. The enzyme's role in regulating lipid metabolism makes it a potential target for drug development. Compounds that can modulate ACOT12 activity may be developed to treat these conditions.
ACOT12 can potentially be targeted with small molecule inhibitors or activators, as well as with biologics such as monoclonal antibodies or RNA-based therapeutics. However, more research is needed to identify the most effective and specific targeting strategies for this protein.
ACOT12 protein is used in both research and industry settings. In research, ACOT12 protein is often used to study lipid metabolism, obesity, diabetes, and other metabolic disorders. In industry, ACOT12 protein may be used in the development of drugs that target lipid metabolism and metabolic diseases.
There have been some studies investigating natural compounds that may have an effect on ACOT12 activity. For example, certain flavonoids found in citrus fruits and green tea have been shown to inhibit ACOT12 in vitro. However, further research is needed to determine the effectiveness and safety of using natural compounds to target ACOT12 in vivo.
ACOT12 protein is known to play a role in lipid metabolism and may have potential applications in the treatment of metabolic disorders such as obesity and type 2 diabetes. Additionally, ACOT12 has been implicated in the regulation of autophagy and oxidative stress, suggesting a potential role in the treatment of neurodegenerative diseases and cancers.
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