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ACTB

  • Official Full Name

    actin, beta

  • Overview

    This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008]
  • Synonyms

    ACTB; actin, beta; BRWS1; PS1TP5BP1; actin, cytoplasmic 1; beta cytoskeletal actin; PS1TP5-binding protein 1;

  • Native Proteins
  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cricetulus Griseus
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Porcine
  • Rat
  • Rhesus Macaque
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Human Platelet
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Porcine brain
  • Wheat Germ
  • Yeast
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|Myc
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACTB-325H Active Native Human ACTB Human Platelet N/A
Human ACTB-3030H Recombinant Human Actin, Beta, His-tagged E.coli His
Human ACTB-133H Recombinant Human ACTB Mammalian Cell His
Human ACTB-225H Recombinant Human ACTB protein, His-tagged E.coli His Met1-Phe375
Human ACTB-1520H Recombinant Human ACTB, GST-tagged Wheat Germ GST
Human ACTB-20HCL Recombinant Human ACTB cell lysate N/A
Human ACTB-267H-B Recombinant Human ACTB Protein Pre-coupled Magnetic Beads HEK293
Human ACTB-1025H Recombinant Human ACTB Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ACTB-2480H Recombinant Human ACTB protein, His&Myc-tagged E.coli His&Myc 1-375aa
Human ACTB-074H Recombinant Human ACTB Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human ACTB-938H Recombinant Human ACTB protein, His&Myc-tagged Insect Cells His&Myc 1-375aa
Human ACTB-2481H Recombinant Human ACTB protein, His-tagged E.coli His 102-375aa
Human ACTB-124H Recombinant Human ACTB Protein, His-tagged E.coli His
Human ACTB-28HFL Recombinant Full Length Human ACTB Protein, C-Flag-tagged Mammalian cells Flag
Human ACTB-267H Recombinant Human ACTB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Actb-3093M Recombinant Mouse Actb, His-tagged E.Coli or Yeast His 375
Mouse Actb-812M Recombinant Mouse Actb Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat ACTB-478R Recombinant Rat ACTB Protein Mammalian Cell His
Rat ACTB-134R Recombinant Rat ACTB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ACTB-134R-B Recombinant Rat ACTB Protein Pre-coupled Magnetic Beads HEK293
Cricetulus Griseus ACTB-2433C Recombinant Cricetulus Griseus ACTB Protein (1-375 aa), His-Myc-tagged Yeast His/Myc 1-375 aa
Cricetulus Griseus ACTB-2449C Recombinant Cricetulus Griseus ACTB Protein (1-375 aa), His-tagged E.coli His 1-375 aa
Cynomolgus Monkey ACTB-269C Recombinant Cynomolgus ACTB Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey ACTB-19C Recombinant Cynomolgus Monkey ACTB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey ACTB-19C-B Recombinant Cynomolgus Monkey ACTB Protein Pre-coupled Magnetic Beads HEK293
Porcine ACTB-882P Native Porcine ACTB Protein Porcine brain N/A
Rhesus Macaque ACTB-221R Recombinant Rhesus monkey ACTB Protein, His-tagged Mammalian Cell His
Rhesus Macaque ACTB-49R Recombinant Rhesus Macaque ACTB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ACTB-49R-B Recombinant Rhesus Macaque ACTB Protein Pre-coupled Magnetic Beads HEK293
Chicken ACTB-7067C Recombinant Chicken ACTB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ACTB Related Articles
  • ACTB Related Research Area

ACTB involved in several pathways and played different roles in them. We selected most pathways ACTB participated on our site, such as Rap signaling pathway, Phagosome, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayPARD6A;GRIN1;AKT1;Fgf15;FYB;FGF10;MAPK3;MAPK13;PFN3
PhagosomeATP6V0B;H2-Q10;C1RA;cgr2b;ATP6V1B1;HLA-F;SCARB1;BLA;FCGR1A
Hippo signaling pathwayCTNNA3;PPP2R1B;TEAD2;SOX2;TGFB2;DLG1;ITGB2;FRMD6;FZD1
Focal adhesionITGB3;MYLK3;MYL2B;GRB2B;VWF;COL1A1B;FIGF;RAC1A;VTN
Adherens junctionRAC2;FYNA;PTBP3;SMAD3A;ACTN2;CTNND1;ACTN3A;ACTN3;CREBBP
Tight junctionAKT1;CSNK2A2A;ACTN3;MPP5A;CDC42L2;PRKCD;PRKCA;F11R.1;MYH1
Platelet activationP2RY12;GNAI2;PTGS1;MYL12A;PLA2G4A;PPP1R12A;ACTG1;SRC;PRKACG
Leukocyte transendothelial migrationMYLPF;ARHGAP5;PIK3R1;MYL2;NCF4;VAV1;ITGAL;NOX3;CLDN14
Regulation of actin cytoskeletonMYL5;ABI2B;CHRM2A;PDGFA;FGF16;ROCK1;PIP5K1B;SSH2;PAK2A
Thyroid hormone signaling pathwayPLCG2;BMP4;HIF1A;PRKCG;PLCZ1;ATP1A4;PIK3CD;RHEB;KAT2B
Oxytocin signaling pathwayCALM2;MAPK1;PLA2G4C;CACNA2D1;CACNG7;GNAI2;CCND1;PRKAB1;GUCY1A3
Gastric acid secretionPRKACA;PLCB2;MYLK2;CALM4;ATP1B1;CAMK2A;KCNK10;KCNJ16;KCNJ15
Bacterial invasion of epithelial cellsCLTA;CLTC;MAD2L2;ITGA5;CAV2;ARPC5L;CRK;SEPT6;ARPC1B
Vibrio cholerae infectionATP6V0E1;ATP6V0B;ATP6V1B2;ATP6V0D2;ATP6V0A1;ATP6V1D;PDIA4;ACTB;ATP6V0C
Pathogenic Escherichia coli infectionWASL;YWHAZ;PRKCA;EZR;CLDN1;ARHGEF2;TUBAL3;ROCK1;TLR4
ShigellosisMAD2L2;RHOG;RIPK2;U2AF1L4;MAPK8;CD44;MAPK11;ABL1;IL-8
Salmonella infectionPLEKHM2;PKN3;DYNC2H1;ROCK1;CCL3;MAPK12;ROCK2A;IL8L1;IL18
Influenza ATMPRSS13;OAS1;FASLG;TNFRSF10A;IFNA12;MAPK10;CASP1;H2-AB1;NXT1
Proteoglycans in cancerPLCG1;IGF2;HGF;MSN;PTCH1;PLCE1;PDPK1;WNT9A;DDX5
Hypertrophic cardiomyopathy (HCM)LAMA2;PRKAB1;ITGA9;TGFB2;SGCG;ITGA1;EMD;MYH7;PRKAA1
Arrhythmogenic right ventricular cardiomyopathy (ARVC)SGCD;CACNA2D1;ITGA1;CACNA2D3;CACNG3;CACNA2D2;ITGA7;TCF7L2;SGCG
Dilated cardiomyopathySLC8A1;LMNA;TNNI3;ITGA1;ITGB3;PLN;CACNA2D2;ACTC1;TPM4
Viral myocarditisSGCD;HLA-DRB4;HLA-A;HLA-DQA2;CD40;HLA-DPB1;CCND1;ABL1;CD28

ACTB has several biochemical functions, for example, ATP binding, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding, contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTB itself. We selected most functions ACTB had, and list some proteins which have the same functions with ACTB. You can find most of the proteins on our site.

Function Related Protein
ATP bindingNEK7;PHKG1B;CAMK1;ATP2C2;TRPM4;NEK6;CSNK1DA;MAPK9;KIF17
contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA bindingSMARCB1;SMARCC1;ACTB;HDAC1;SMARCE1;MTA2;SMARCC2;HDAC2;CHD4
contributes_to RNA polymerase II distal enhancer sequence-specific DNA bindingACTL6A;HDAC1;GATAD2B;HDAC2;RBBP4;CHD4;MBD3;ACTB;SMARCA4
Tat protein bindingNPM1;SMARCA4;GABARAPL1;SMARCB1;TRIM32;MDFIC;DLL1;ACTB
identical protein bindingCBLL1;CLDN4;BAG2;RUVBL2;TRA@;LTBR;ATL2;AHCY;CLDN14
kinesin bindingKTN1;PRC1;AP1AR;PPIAL4A;TOR1A;KLC2;JIP1;PIFO;ARPC2
nitric-oxide synthase bindingSLC14A2;CD74;DNM2;DMD;CALM3;DNM3;SLC6A4;ATP2B4;CALM1
contributes_to nucleosomal DNA bindingRBBP4;SMARCE1;GATAD2B;HDAC2;SMARCA4;ACTL6A;SMARCB1;MTA2;MBD3
protein bindingSCAMP5;HHLA3;FNBP1;RALY;CENPJ;CMKLR1;SMC6;FIBPB;VEZT
structural constituent of cytoskeletonMSN;ACTG1;SYNM;TUBGCP5;AGRN;KRT71;DMD;SORBS2;KRT20

ACTB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTB here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTB.

ACTG1; CFL1; DSTN; ESR1

Bonnans, C; Lohela, M; et al. Real-time Imaging of Myeloid Cells Dynamics in Apc(Min/+) Intestinal Tumors by Spinning Disk Confocal Microscopy. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2014).
Matsumoto, C; Ito, M; et al. Preparation of thyroid follicular cells for mRNA quantification after fluorescence-activated cell sorting. SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION 73:245-252(2013).
  • Q&As
  • Reviews

Q&As (20)

Ask a question
Which biological process GO terms were identified through the PPI analysis? 12/12/2022

 The PPI analysis identified several biological process GO terms such as "Actin cytoskeleton organization," "Box C/D snoRNP assembly," "Actin filament depolymerization," "Cell junction assembly," and "DNA repair."

 What was the focus of the current study mentioned? 01/25/2022

The current study aimed to analyze the diagnostic value of ACTB and predict its independent prognostic factor in distinct cancer subtypes using detailed in silico analysis.

How could ACTB potentially serve as a biomarker in LIHC, HNSC, and LUAD? 11/23/2021

The findings suggest that due to its elevated expression, association with poorer survival and metastasis, and correlation with important parameters such as immune infiltration and tumor purity, ACTB has the potential to be a candidate biomarker for LIHC, HNSC, and LUAD.

How is ACTB related to the metastasis of different cancers? 07/30/2021

The dysregulation and polymerization of ACTB have been revealed to be associated with the metastasis of different cancer types.

Which drugs were found to reduce the expression level of ACTB? 05/19/2021

Warfarin and aflatoxin B1 were found to potentially reduce the expression level of ACTB.

How many highly significant transcription factors (TFs) were identified as potential regulators of ACTB expression? 04/01/2021

Ten highly significant TFs were identified as potential regulators of ACTB expression. They are AATF, WWTR1, GFI1, NR3C1, MYC, GFI1, STAT3, ING1, MAX, and POU4F1.

What do the results suggest about the regulation of ACTB expression? 11/25/2020

The results indicate that a variety of different regulators, including miRNAs and TFs, are involved in the regulation of ACTB expression.

What analytical method was used to identify potential regulators of ACTB expression? 12/18/2019

Enrichr analysis was used to identify potential regulators of ACTB expression.

What molecular functions were associated with the ACTB-associated genes? 07/08/2019

The molecular functions associated with the ACTB-associated genes included "Actin monomer binding," "ATPase activity," "Leucine zipper domain binding," and "DNA helicase activity."

Which drugs were found to elevate the expression level of ACTB? 06/07/2019

Valporic acid and metribolone were found to potentially elevate the expression level of ACTB.

What is the significance of ACTB (eta-actin) as a housekeeping gene? 01/01/2019

ACTB serves as a housekeeping gene commonly used as a control in measuring gene expression in various diseases.

How many miRNAs were found to have the potential to change ACTB expression? 09/24/2018

Ten miRNAs were identified as potential regulators of ACTB expression. They are hsa-miR-1908, hsa-miR-663, hsa-miR-744, hsa-miR-4745-3p, hsa-miR-1538, hsa-miR-3960, hsa-miR-4749-5p, hsa-miR-4706, hsa-miR-4743, and hsa-miR-3180-3p.

In which specific cancers was elevated ACTB expression associated with poorer survival and metastasis? 06/10/2018

Elevated ACTB expression was associated with poorer survival and metastasis specifically in liver hepatocellular carcinoma (LIHC), head and neck squamous cancer (HNSC), and lung adenocarcinoma (LUAD).

What did the protein-protein interaction (PPI) analysis reveal about ACTB-associated genes? 07/06/2017

The PPI analysis revealed a set of ten ACTB-associated genes that are involved in various biological processes, including "Actin cytoskeleton organization," "Box C/D snoRNP assembly," "Actin filament depolymerization," "Cell junction assembly," and "DNA repair."

What analytical approach was used in the study? 06/21/2017

The study utilized in silico analysis to assess the diagnostic value and independent prognostic factor of ACTB in different cancer subtypes.

How was ACTB expression influenced through CTD analysis? 06/17/2017

Through CTD analysis, it was observed that ACTB expression can potentially be influenced by a number of drugs.

Which cancers have been found to have a close association with ACTB expression? 05/22/2017

 ACTB expression has been found to be closely related to various cancers, including liver, pancreatic, renal, colorectal, melanoma, prostate, esophageal, lung, gastric, breast, and ovarian cancers.

How was ACTB-associated expression regulated in the study? 10/26/2016

The study explored ACTB-associated clinically important expression regulators, including TFs (transcription factors), miRNAs, and different chemotherapeutic drugs.

What was observed regarding ACTB expression in major human cancer tissues compared to normal samples? 05/21/2016

ACTB expression was found to be remarkably higher in 24 major human cancer tissues compared to normal samples.

What other parameters did ACTB up-regulation show interesting correlations with? 01/23/2016

ACTB up-regulation showed interesting correlations with immune infiltration of CD4+ T and CD8+ T cells, tumor purity, mutant genes, and other important parameters.

Customer Reviews (5)

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Reviews
08/19/2022

    I could trust the product's precision, ensuring reliable data generation

    08/15/2021

      The protein product had an impressive shelf life, maintaining its quality and functionality over an extended period

      03/04/2021

        The protein product seamlessly integrated with various experimental techniques, enhancing its versatility

        02/23/2020

          The protein product underwent rigorous safety testing, ensuring its reliability and suitability for experimentation

          06/19/2018

            The protein product line offered a wide variety of options for different research need

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