ACTL6B
-
Official Full Name
actin-like 6B
-
Overview
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain. -
Synonyms
ACTL6B; actin-like 6B; actin like 6 , ACTL6; actin-like protein 6B; BAF53B; arpNalpha; hArpN alpha; actin-like 6; BRG1-associated factor 53B; actin-related protein Baf53b; 53 kDa BRG1-associated factor B; ACTL6;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ACTL6B Related Research Area
ACTL6B involved in several pathways and played different roles in them. We selected most pathways ACTL6B participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Prostate Cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTL6B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Chromatin modifying enzymes | KDM5A;PRMT7;KDM2A;VPS72;C20orf20;KDM2AA;MBD3B;KAT8;JMJD6 |
Chromatin organization | MSL3;CHD4;JADE1;GATAD2A;C20orf20;KDM6AL;TADA2A;KDM5B;PBRM1 |
Prostate Cancer | PDGFC;CREB5;PDGFRA;AKT2;RAF1;RB1;KRAS;SMARCA4;ACTL6B |
RMTs methylate histone arginines | SMARCC1B;ARID1A;SMARCE1;SMARCC1;SMARCB1B;WDR77;SMARCD3;ARID2;SMARCD3B |
ACTL6B has several biochemical functions, for example, structural constituent of cytoskeleton, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTL6B itself. We selected most functions ACTL6B had, and list some proteins which have the same functions with ACTL6B. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
structural constituent of cytoskeleton | KRT15;SPRR2A1;HIP1;NEFM;TUBA8L3;TUBG1;SPTB;CYLC2;GFAP |
transcription coactivator activity | MYSM1;PPARGC1A;HSF2;MED23;MED7;RXRA;GMEB2;PARK7;TFDP1 |
ACTL6B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTL6B here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTL6B.
SMARCA2; COQ9; TK1; ANXA7; CDKN1A; GSK3B; PLK1; CSNK2B; ATM; SMN1
- Q&As
- Reviews
Q&As (21)
Ask a questionWhile the main known interacting partners of ACTL6B are within the nBAF complex, additional interactions with other proteins or complexes have not been extensively characterized.
Yes, ACTL6B is implicated in neuronal development and differentiation, as it is required for proper chromatin remodeling during neuronal maturation.
ACTL6B is evolutionarily conserved across different species, indicating its functional importance throughout evolution.
Alternative splicing variants of ACTL6B have not been widely reported in the literature. The majority of studies focus on the canonical isoform of ACTL6B.
Specific post-translational modifications of ACTL6B, such as phosphorylation or acetylation, have not been extensively studied.
ACTL6B loss is a significant cause of recessive ASD, suggesting its involvement in the development of this disorder.
ACTL6B plays a role in chromatin remodeling, gene regulation, and transcriptional control in various cell types, particularly in postmitotic neurons.
Yes, ACTL6B shares structural similarities with other actin-like proteins, including the presence of an actin fold and conserved residues involved in protein-protein interactions.
ACTL6B is primarily localized in the nucleus, where it exerts its functions in chromatin remodeling and gene regulation.
ACTL6B, as part of the nBAF complex, is involved in chromatin remodeling and gene regulation, particularly in postmitotic neurons. It plays a role in shaping the chromatin landscape and influencing cellular processes related to neuronal development and function.
ACTL6B belongs to the actin-like protein family, which comprises proteins that share structural similarities with actin but may have distinct functions and roles in cellular processes.
Yes, ACTL6B has a paralog called ACTL6A (Actin-like 6A), which shares similarities in structure and function.
Currently, there are no specific genetic disorders linked to ACTL6B mutations
The nBAF complex, including ACTL6B, plays a role in modifying the structure of chromatin, allowing for proper gene regulation and functional changes in postmitotic neurons.
ACTL6B is a component of the neuronal BRG1/brm-associated factor (nBAF) complex, which is required for chromatin remodeling specifically in postmitotic neurons.
Yes, ACTL6B interacts with other proteins within the neuronal BRG1/brm-associated factor (nBAF) complex, including various subunits involved in chromatin remodeling and gene regulation.
While the main known interacting partners of ACTL6B are within the nBAF complex, additional interactions with other proteins or complexes have not been extensively characterized.
Targeting ACTL6B or the nBAF complex could hold therapeutic potential for ASD; however, further research is needed to understand the precise mechanisms involved and to evaluate the feasibility and effectiveness of such targeting approaches.
ACTL6B is widely expressed in various tissues, but its expression is particularly prominent in the brain, where it plays a crucial role in neuronal development and function.
Impaired neuron-specific chromatin repression is proposed as a potential mechanism underlying the association between ACTL6B loss and ASD.
ACTL6B belongs to the actin-like protein family and has a conserved structure similar to actin proteins. It consists of a globular domain and a flexible C-terminal tail.
Customer Reviews (5)
Write a reviewIncreased protein expression, enhanced cell proliferation, or inhibition of specific biological processes, when using this protein.
The packaging includes proper labeling and documentation, facilitating easy identification and handling of the protein product upon arrival.
They have provided valuable technical guidance and troubleshooting assistance, helping us optimize our experimental protocols and achieve better results.
We have successfully replicated our findings using multiple batches of the protein product, indicating its reliable and consistent behavior.
The protein product is produced using state-of-the-art manufacturing techniques, ensuring consistent quality and performance.
Ask a Question for All ACTL6B Products
Required fields are marked with *
My Review for All ACTL6B Products
Required fields are marked with *