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ADA

  • Official Full Name

    adenosine deaminase

  • Overview

    This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been;described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe;combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired;cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been;associated with congenital hemolytic anemia.
  • Synonyms

    ADA; adenosine deaminase; adenosine aminohydrolase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Assay Kits
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • Bovine Intestine
  • E. coli
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADA-39H Active Recombinant Human ADA protein E.coli N/A
Human ADA-1112H Active Recombinant Human ADA protein, His-tagged Insect Cell His
Human ADA-40H Recombinant Human ADA Protein, 1-363aa, N-His tagged E. coli N-His 1-363aa
Human ADA-120H Recombinant Human ADA, His tagged Insect Cell Fc
Human ADA-3H Recombinant Human Adenosine Deaminase N/A
Human ADA-1007H Recombinant Human ADA, His-tagged E.coli His
Human ADA-268H Recombinant Human ADA Protein, GST-tagged Wheat Germ GST
Human ADA-001HCL Recombinant Human ADA cell lysate Insect Cell N/A
Human ADA-840HF Recombinant Full Length Human ADA Protein, GST-tagged In Vitro Cell Free System GST 363 amino acids
Human ADA-9H Human Adenosine deaminase Reference Standard N/A
Human ADA-0652H Recombinant Human ADA Protein (Lys11-Val280), N-His-tagged E.coli N-His Lys11-Val280
Human ADA-0689H Recombinant Human ADA Protein (Lys11-Val280) E.coli Tag Free Lys11-Val280
Mouse ADA-1271M Recombinant Mouse ADA Protein Mammalian Cell His
Mouse Ada-3155M Recombinant Mouse Ada, His-tagged E.Coli or Yeast His 352
Mouse ADA-303M Recombinant Mouse ADA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ADA-303M-B Recombinant Mouse ADA Protein Pre-coupled Magnetic Beads HEK293
Rat ADA-499R Recombinant Rat ADA Protein Mammalian Cell His
Rat ADA-155R-B Recombinant Rat ADA Protein Pre-coupled Magnetic Beads HEK293
Rat ADA-155R Recombinant Rat ADA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bovine ADA-P036B Native Bovine adenosine deaminase therapeutic protein (Pegademase bovine) Bovine Intestine N/A
Zebrafish ADA-756Z Recombinant Zebrafish ADA Mammalian Cell His
Chicken ADA-1435C Recombinant Chicken ADA Mammalian Cell His
Kit-2148 Adenosine Deaminase Fluorometric Activity Assay Kit N/A
Kit-1101 Adenosine Deaminase Activity Assay Kit (Colorimetric) N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADA Related Articles

ADA involved in several pathways and played different roles in them. We selected most pathways ADA participated on our site, such as C-MYB transcription factor network, Metabolic pathways, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
C-MYB transcription factor networkYEATS4;PPID;ELANE;CDK6;COL1A2;CSF1R;CDKN1B;CREBBP;MYF6
Metabolic pathwaysCBS;POLR2J3;LPCAT4;CKBB;ALDH1A3;CKMT2B;HADHA;NDUFB8;PTGES2
MetabolismSLC35D1A;ARSH;ELA2;PPP1R2;CYP2K19;ACOT9.2;MED23;ATP5L;CPNE7
Metabolism of nucleotidesDUT;DPYD;NUDT18;NUDT15;DTYMK;ADA;TM9SF1;PAICS;PNP5B
Primary immunodeficiencyCD3E; CD3D;ADA;TNFRSF13C
Purine metabolismGUK1B;POLA2;GUCY1A3;AK5;ADSSL;PKMA;NT5C1B-RDH14;PDE8A;ADKB
Purine salvagePNP5B;TM9SF1;ADA;DGUOK;ADK;DCK;ADAL
adenine and adenosine salvage III

ADA has several biochemical functions, for example, adenosine deaminase activity, protein binding, purine nucleoside binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADA itself. We selected most functions ADA had, and list some proteins which have the same functions with ADA. You can find most of the proteins on our site.

Function Related Protein
adenosine deaminase activityADAD2;ADARB1;ADARB1A;ADARB2;CECR1;CECR1A;ADAD1;ADAL;ADA
protein bindingLSM7;FAM58A;RELA;SERPINI2;PAAF1;SMN1;PER3;HERC5;IRF4
purine nucleoside bindingADORA1;ADA;C6orf130
zinc ion bindingDPF3;RAG1;BHMT2;ASH1L;ESRRGA;CA7;PAPPA2;MTA3;MKRN2

ADA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADA here. Most of them are supplied by our site. Hope this information will be useful for your research of ADA.

PIAS2; SGCD; TINF2; TERF2IP

Zhang, JC; Yu, BB; et al. Non-Normal Random Effects Models for Immunogenicity Assay Cut Point Determination. JOURNAL OF BIOPHARMACEUTICAL STATISTICS 25:295-306(2015).
Zandvliet, A; Glasgow, S; et al. Tildrakizumab, a novel anti-IL-23 monoclonal antibody, is unaffected by ethnic variability in Caucasian, Chinese, and Japanese subjects. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 53:139-146(2015).
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