adam10
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  • Official Full Name
  • ADAM metallopeptidase domain 10
  • Background
  • Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ADAM10; ADAM metallopeptidase domain 10; RAK; kuz; AD10; AD18; MADM; CD156c; HsT18717; disintegrin and metalloproteinase domain-containing protein 10; CDw156; kuzbanian protein homolog; mammalian disintegrin-metalloprotease; a disintegrin and metalloprotease domain 10;
Cat.#:ADAM10-265HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADAM 10, His-tagged
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Cat.#:Adam10-1927MTag:His
Source (Host):Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Adam10, His-tagged
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Cat.#:ADAM10-18HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human ADAM10, His-tagged
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Cat.#:ADAM10-272HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADAM10 Protein, GST-tagged
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Cat.#:ADAM10-7638HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADAM10 protein, His-tagged
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Cat.#:ADAM10-924HTag:His
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Human
Product nameRecombinant Human ADAM10 Protein, His-tagged
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Cat.#:ADAM10-1275MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ADAM10 Protein
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Cat.#:Adam10-961MTag:His
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Adam10 Protein, His-tagged
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Cat.#:Adam10-7639RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Adam10 protein, His-tagged
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Cat.#:ADAM10-5834CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ADAM10
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Involved Pathway

ADAM10 involved in several pathways and played different roles in them. We selected most pathways ADAM10 participated on our site, such as Activated NOTCH1 Transmits Signal to the Nucleus, Alzheimers disease, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activated NOTCH1 Transmits Signal to the Nucleus
DTX2; DLK1; CNTN1; ADAM10; JAG2; MIB1; JAG1; DNER
Alzheimers disease
COX6A2; CALM1; PPP3CC; UQCRC1; FADD; GRIN1; ADAM17; TNF; PSENEN; CALML5
Axon guidance
GSK3B; COL9A1B; ARHGEF12; JAK3; CSNK2A1; DCX; SPNA1; MARK3; PAK6; DPYSL4
Collagen degradation
COL23A1; MMP11; CTSLL; MMP10; COL25A1; MGC174857; CTSK; COL15A1B; COL13A1; CTSB
Constitutive Signaling by NOTCH1 HD Domain Mutants
ADAM10; MIB1; JAG1; JAG2
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
JAG2; MIB1; JAG1; HDAC6; HEY1; HEYL; CDK8; HEY2; ADAM10; CCNC
Constitutive Signaling by NOTCH1 PEST Domain Mutants
ADAM10; HDAC5; HEY2; CDK8; HEY1; MIB1; HDAC6; HEYL; CCNC; JAG2

Protein Function

ADAM10 has several biochemical functions, for example, SH3 domain binding, endopeptidase activity, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM10 itself. We selected most functions ADAM10 had, and list some proteins which have the same functions with ADAM10. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein SH3BGRL2; DOCK1; PLSCR1; OSTF1; DENND1A; ADAM17; DPYSL3; MAPT; PLSCR4; SKAP1
Function endopeptidase activity
Related Protein CPS1; TPP1; REN2; PSMB6; KLK1B9; PSMB8; NCSTN; HTRA3; FURIN; PSMA1
Function integrin binding
Related Protein TLN1; SFRP2; GFAP; CXADR; TIMP2; GPNMB; SYK; TSPAN4; THBS1; VCAM1
Function metalloendopeptidase activity
Related Protein ADAM22; ADAMTS5; MMP11; ADAMTS18; ADAM9; MMP20; UQCRC1; OMA1; MMEL1; MMP16
Function metallopeptidase activity
Related Protein ADAM10B; CLCA5; ECEL1; ADAM18; MMP2; ADAM21; XPNPEP3; ADAM2; ANPEP; ANPEPA
Function protein binding
Related Protein FCER2; CD8B1; JAKMIP2; DEPDC6; ERCC5; E2F1; GRIN2B; FCNA; LC3; PMS2
Function protein homodimerization activity
Related Protein NR6A1; SLC26A5; C1QB; NDP; FZD1; RPS19; FGFR2; E2F8; CPOX; GIPC1
Function protein kinase binding
Related Protein GHR; MSH2; RPS3; MSN; KCNQ3; CD226; SPDYE2; FAM83D; KAT2B; DNM1
Function receptor binding
Related Protein NTF7; Ren1; CRAT; KCNJ10; DECR2; PICK1; CAPRIN2; HAO1; PDGFRB; IDH1
Function zinc ion binding
Related Protein BPTF; PGLYRP5; MMP26; OAS2; APOBEC2B; ZKSCAN5; NR2F1B; DNMT5; MEP1B; ING5B

Interacting Protein

ADAM10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM10 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM10.
PDIA3; AR; PHB; btuB; pi3p; CD9

ADAM10 Related Articles

Martin, RK; Brooks, KB; et al. Antigen Transfer from Exosomes to Dendritic Cells as an Explanation for the Immune Enhancement Seen by IgE Immune Complexes. PLOS ONE 9:-(2014).
Sampedro, GR; DeDent, AC; et al. Targeting Staphylococcus aureus alpha-Toxin as a Novel Approach to Reduce Severity of Recurrent Skin and Soft-Tissue Infections. JOURNAL OF INFECTIOUS DISEASES 210:1012-1018(2014).