Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

ADAMTS1

  • Official Full Name

    ADAM metallopeptidase with thrombospondin type 1 motif, 1

  • Overview

    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]
  • Synonyms

    ADAMTS1; ADAM metallopeptidase with thrombospondin type 1 motif, 1; C3-C5; METH1; A disintegrin and metalloproteinase with thrombospondin motifs 1; METH-1; ADAM-TS1; ADAMTS-1; ADAM-TS 1; human metalloproteinase with thrombospondin type 1 motifs; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • CHO
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADAMTS1-532H Active Recombinant Human ADAMTS1, His-tagged Insect Cell His
Human ADAMTS1-295H Active Recombinant Human ADAMTS1 Protein, His-tagged Insect Cell His
Human ADAMTS1-296H Recombinant Human ADAMTS1 Protein, GST-tagged Wheat Germ GST
Human ADAMTS1-531H Recombinant Human ADAMTS1, His-tagged Mammalian cells His
Human ADAMTS1-105H Recombinant Human ADAMTS1, GST-tagged E.coli GST 253-546aa
Human ADAMTS1-2048H Recombinant Human ADAMTS1 protein, His-tagged E.coli His Arg258~Pro467 (Accession # Q9UHI8)
Human ADAMTS1-2423H Recombinant Human ADAMTS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ADAMTS1-2423H-B Recombinant Human ADAMTS1 Protein Pre-coupled Magnetic Beads HEK293
Human ADAMTS1-0163H Recombinant Human ADAMTS1 Protein (Arg258-Pro467), His-tagged E.coli His Arg258-Pro467
Mouse Adamts1-441M Active Recombinant Mouse A Disintegrin-Like And Metallopeptidase (reprolysin type) With Thrombospondin Type 1 Motif, 1, His-tagged CHO His
Mouse Adamts1-2049M Recombinant Mouse Adamts1 protein, His-tagged E.coli His His560~Pro911 (Accession # P97857)
Mouse ADAMTS1-1307M Recombinant Mouse ADAMTS1 Protein Mammalian Cell His
Mouse ADAMTS1-321M Recombinant Mouse ADAMTS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ADAMTS1-321M-B Recombinant Mouse ADAMTS1 Protein Pre-coupled Magnetic Beads HEK293
Rat Adamts1-2050R Recombinant Rat Adamts1 protein, His-tagged E.coli His Asp476~Pro614 (Accession # Q9WUQ1)
Rhesus Macaque ADAMTS1-234R Recombinant Rhesus monkey ADAMTS1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ADAMTS1-62R Recombinant Rhesus Macaque ADAMTS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ADAMTS1-62R-B Recombinant Rhesus Macaque ADAMTS1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADAMTS1 Related Articles
  • ADAMTS1 Related Research Area

ADAMTS1 involved in several pathways and played different roles in them. We selected most pathways ADAMTS1 participated on our site, such as Degradation of the extracellular matrix, Endochondral Ossification, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Degradation of the extracellular matrixCAPNS1;MGC174857;FAM49BA;TPSAB1;MMP11;FURINA;BMP1A;CTSL2;COL15A1B
Endochondral OssificationDDR2;IFT88;ADAMTS4;NKX3-2;CTSL2;PTH;CDKN1C;ADAMTS1;PTHLH
Extracellular matrix organizationCOL9A3;ADAMTS5;MATN1;LAMB1B;CTSB;COL13A1;PRP;MMP19;MMP15
Metabolism of proteinsEIF5;PAPPA2;TRAPPC10;PFDN2;INHBAA;F9B;MUC1;WIPI1;MPDU1A
O-glycosylation of TSR domain-containing proteinsADAMTS1;C8orf84;ADAMTS20;ADAMTS18;ADAMTSL4;ADAMTS8;ADAMTSL5;ADAMTSL1;THSD1
O-linked glycosylationMUC15;MUCL1;SPON1A;GCNT3;ADAMTS8;THSD7A;ST6GALNAC2;MUC1;SPON1
Post-translational protein modificationGCNT3;CBX4;NAPG;EIF5A2;ALG10B;SENP5;STT3A;DAD1;DPAGT1

ADAMTS1 has several biochemical functions, for example, heparin binding, metalloendopeptidase activity, metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS1 itself. We selected most functions ADAMTS1 had, and list some proteins which have the same functions with ADAMTS1. You can find most of the proteins on our site.

Function Related Protein
heparin bindingWISP3;Epy;CFH;FGF2;FGF10;CCL8;LIPG;CHRD;ELANE
metalloendopeptidase activityXRCC6BP1;MMP20;MIPEP;MMP23B;PHEX;ADAM10A;ADAM7;ADAM8A;MEP1A
metallopeptidase activityADAM12;GM12824;NAALAD2;HE2;MMP1A;MEP1A.2;MMP13A;ADAM23;C6AST4
zinc ion bindingPRICKLE1A;TRIM71;HERC2;LMO4;SYTL4;NEURL1AB;ADAM15;FTR43;SPRYD5

ADAMTS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS1.

USP17L24; trpE

Foulcer, SJ; Nelson, CM; et al. Determinants of Versican-V1 Proteoglycan Processing by the Metalloproteinase ADAMTS5. JOURNAL OF BIOLOGICAL CHEMISTRY 289:27859-27873(2014).
Dallaglio, K; Bruno, A; et al. Paradoxic effects of metformin on endothelial cells and angiogenesis. CARCINOGENESIS 35:1055-1066(2014).
  • Q&As
  • Reviews

Q&As (11)

Ask a question
What is the structure domain of ADAMTS1? 11/10/2022

Pro-peptide, metallo proteinase, depolymerase/cysteine enriched region, spacer region and thrombospondin type I repeat.

My customization requirements are not listed on the page, can it be customized? 08/10/2022

Yes, you can first communicate with our experts for customized requirements.

Is it also possible to shorten the lead time for custom-manufactured proteins? 03/11/2022

The delivery cycle of this kind of protein is related to your specific customization requirements, you can communicate with our experts first.

Do you offer ADAMTS1 protein fused with other tags? 12/14/2021

We can provide ADAMTS1 protein fused with other tags.

Is ADAMTS1 widely used in disease research? 10/16/2021

ADAMTS1 applied to a variety of diseases including colon, oesophageal and lung cancers.

What physiological and pathological processes is ADAMTS1 involved in? 03/06/2021

ADAMTS1 is involved in the physiological and pathological processes of human growth and development, the formation of the urinary and reproductive systems, and the development of tumours in tissues and organs.

What are the consequences of ADAMTS1 inactivation? 01/07/2021

Inactivation of ADAMTS1 causes infertility and developmental delay in females.

Is there a discount for all ADAMTS1 proteins? 12/12/2020

Yes, all ADAMTS1 proteins are currently discounted.

What proteins does ADAMTS1 degrade? 10/26/2020

ADAMTS1 degrades extracellular matrix proteins such as versican , aggrecan , syndecan and nidogen.

I saw that proteins can be customized, can I customize ADAMTS1 for specific bands? 07/15/2019

Yes, our team can customize the protein according to your requirements.

What is the effect of adding trehalose on the preservation of protein? 06/08/2019

Trehalose can prevent protein secondary structure changes, elongation and aggregation during freeze-drying.

Customer Reviews (3)

Write a review
Reviews
03/01/2021

    Excellent after-sales service, solving many experimental problems.

    06/30/2020

      The products provided by your company are inexpensive and of high quality, and because of this, my experiments could be completed successfully.

      09/03/2019

        The price of the product is right and the quality meets my research needs.

        Ask a Question for All ADAMTS1 Products

        Required fields are marked with *

        My Review for All ADAMTS1 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends