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ADAMTS4

  • Official Full Name

    ADAM metallopeptidase with thrombospondin type 1 motif, 4

  • Overview

    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]
  • Synonyms

    ADAMTS4; ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADMP-1; ADAMTS-2; ADAMTS-4; A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADAMTS4-1028H Active Recombinant Human ADAMTS4 Protein, His-tagged CHO His Phe213-Cys685
Human ADAMTS4-534H Active Recombinant Human ADAMTS4, His-tagged CHO N/A
Human ADAMTS4-533H Active Recombinant Human ADAMTS4, His-tagged Insect Cell His
Human ADAMTS4-536H Recombinant Human ADAMTS4, GST-tagged Wheat Germ GST
Human ADAMTS4-537H Recombinant Human ADAMTS4, MYC/DDK-tagged HEK293 Myc/DDK
Human ADAMTS4-535H Recombinant Human ADAMTS4, GST-tagged Wheat Germ GST
Human ADAMTS4-538H Recombinant Human ADAMTS4, MYC/DDK-tagged HEK293 N/A
Human ADAMTS4-9029HCL Recombinant Human ADAMTS4 293 Cell Lysate HEK293 N/A
Human ADAMTS4-3636H Recombinant Human ADAMTS4 protein, His-tagged E.coli His 48-159 aa
Human ADAMTS4-1754H Recombinant Human ADAMTS4 protein, His-tagged E.coli His Thr437~Pro575 (Accession # O75173)
Human ADAMTS4-3744H Recombinant Human ADAMTS4 protein, GST-tagged E.coli GST 48-159 aa
Human ADAMTS4-1431H Recombinant Human ADAMTS4 protein, GST-tagged E.coli GST 213-319aa
Mouse Adamts4-1530M Recombinant Mouse Adamts4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat ADAMTS4-506R Recombinant Rat ADAMTS4 Protein Mammalian Cell His
Rat ADAMTS4-162R Recombinant Rat ADAMTS4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ADAMTS4-162R-B Recombinant Rat ADAMTS4 Protein Pre-coupled Magnetic Beads HEK293
Rat Adamts4-75R Recombinant Rat Adamts4 Protein, His-tagged E.coli N-His Met13-Gly289
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADAMTS4 Related Articles
  • ADAMTS4 Related Research Area

ADAMTS4 involved in several pathways and played different roles in them. We selected most pathways ADAMTS4 participated on our site, such as Degradation of the extracellular matrix, Endochondral Ossification, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Degradation of the extracellular matrixLOC100686744;CTSL1;ADAMTS4;COL17A1;MMP15;EMID2;MMP10;MMP12;CAPNS1
Endochondral OssificationCTSL2;COL2A1;ADAMTS5;PTH;CDKN1C;FRZB;RUNX3;SOX9A;MMP13
Extracellular matrix organizationTLL2;CAPNS1;CTSLL;KLK7;MATN3;ADAM8A;MFAP3;COL28A1D;COL2A1
Metabolism of proteinsYY2;TBCB;MUC5AC;PFDN2;STT3A;CPN1;FXC1;A4GNT;TIMM17A
O-glycosylation of TSR domain-containing proteinsADAMTS13;SSPO;ADAMTS5;ADAMTSL3;ADAMTS1;ADAMTSL5;ADAMTS15;THSD1;ADAMTS8
O-linked glycosylationADAMTS8;GALNT6;ADAMTSL1;B3GNT8;SPON1A;MUC5AC;MUC20;ADAMTSL4;ADAMTS18
Post-translational protein modificationADAMTS5;ST6GALNAC1.2;PPP6C;MUC1;KCNA6;MLEC;C8orf84;MAN1B1;TRAPPC1

ADAMTS4 has several biochemical functions, for example, metalloendopeptidase activity, metallopeptidase activity, peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS4 itself. We selected most functions ADAMTS4 had, and list some proteins which have the same functions with ADAMTS4. You can find most of the proteins on our site.

Function Related Protein
metalloendopeptidase activityADAM8A;MIPEP;ECEL1;PMPCB;MMEL1;ECE1;ADAMTS2;ADAM23;ADAM17A
metallopeptidase activityDNPEP;ADAM21;ADAM1B;MMP9;COPS5;STAMBPL1;HE2;CNDP1;NPEPPS
peptidase activityCTSLL;PCSK5B;MMP23BB;HTRA1A;CLCA3;METAP2A;CTSH;TMPRSS13B;ELANE
protease bindingSERPINA5;SERPINB9;LCN2;FLOT1;CAST;INS2;ITGAV;FLOT2;INS1
protein bindingOTUD7B;SNX8;MAGEA1;GRK5;BLOC1S4;GNPDA2;GGNBP2;PEX1;RAB5B
zinc ion bindingMYT1LA;RNF214;KDM2B;KDM5BA;RARGA;HLTF;TRIM35-24;RNF180;SEC23B

ADAMTS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS4.

ZBTB16; YTHDC1

Valenzuela, JC; Heise, C; et al. Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 369:-(2014).
Wainwright, SD; Bondeson, J; et al. ADAMTS-4_v1 Is a Splice Variant of ADAMTS-4 That Is Expressed as a Protein in Human Synovium and Cleaves Aggrecan at the Interglobular Domain. ARTHRITIS AND RHEUMATISM 65:2866-2875(2013).
  • Q&As
  • Reviews

Q&As (5)

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What is ADAMTS4 secreted by? 09/11/2022

ADAMTS4 is an inflammatory factor secreted by macrophages.

What is the relationship between ADAMTS4 and IL-1β? 12/01/2021

IL-1β can induce ADAMTS4 expression.

Where is ADAMTS4 expressed? 04/10/2021

ADAMTS4 is expressed in the heart, joint tissues, lungs, and other sites.

What is the biological function of ADAMTS4? 01/02/2021

ADAMTS4 is involved in the degradation of multifunctional proteoglycans in the vascular wall.

What diseases is ADAMTS4 used to study? 10/19/2020

ADAMTS4 could be used in research into diseases such as colorectal and gastric cancer.

Customer Reviews (3)

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Reviews
09/05/2021

    Professional personnel to provide after-sales service, experimental results are guaranteed.

    10/21/2020

      High protein concentration, good quality, worth buying.

      08/21/2019

        The technicians were very professional and suggested improvements to my experimental program, which allowed the experiment to go smoothly.

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