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ADD2

  • Official Full Name

    adducin 2 (beta)

  • Overview

    Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described.
  • Synonyms

    ADD2; adducin 2 (beta); beta-adducin; ADDB; ADD 2; ADDB_HUMAN; Adducin2; Beta adducin; Erythrocyte adducin subunit beta; OTTHUMP00000203378; OTTHUMP00000203908;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADD2-9414H Recombinant Human ADD2, His-tagged E.coli His 1-331a.a.
Human ADD2-337H Recombinant Human ADD2 Protein, GST-tagged Wheat Germ GST
Human ADD2-9015HCL Recombinant Human ADD2 293 Cell Lysate HEK293 N/A
Human ADD2-9016HCL Recombinant Human ADD2 293 Cell Lysate HEK293 N/A
Human ADD2-6323H Recombinant Human ADD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ADD2-2935H Recombinant Human ADD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ADD2-13HF Recombinant Full Length Human ADD2 Protein In Vitro Cell Free System 726 amino acids
Human ADD2-26138TH Recombinant Human ADD2 Wheat Germ N/A 726 amino acids
Human ADD2-301607H Recombinant Human ADD2 protein, GST-tagged E.coli GST Met1-Leu331
Human ADD2-908HF Recombinant Full Length Human ADD2 Protein, GST-tagged In Vitro Cell Free System GST 726 amino acids
Mouse ADD2-1351M Recombinant Mouse ADD2 Protein Mammalian Cell His
Mouse ADD2-340M-B Recombinant Mouse ADD2 Protein Pre-coupled Magnetic Beads HEK293
Mouse ADD2-340M Recombinant Mouse ADD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Add2-540M Recombinant Mouse Add2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque ADD2-243R Recombinant Rhesus monkey ADD2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ADD2-71R Recombinant Rhesus Macaque ADD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ADD2-71R-B Recombinant Rhesus Macaque ADD2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADD2 Related Articles

ADD2 involved in several pathways and played different roles in them. We selected most pathways ADD2 participated on our site, such as Miscellaneous transport and binding events, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Miscellaneous transport and binding eventsMMGT1;ADD3B;ADD3;PIP;MAGT1;AZGP1;MRS2;CTNS;ADD2
Transmembrane transport of small moleculesTRPM4A;SLC6A20A;ADD3A;SLC15A3;SLC39A6;MATE4;SLC6A6;SLC35A1;SLC27A4

ADD2 has several biochemical functions, for example, actin binding, actin filament binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADD2 itself. We selected most functions ADD2 had, and list some proteins which have the same functions with ADD2. You can find most of the proteins on our site.

Function Related Protein
actin bindingCAP2;AVIL;ANTXR2A;PHACTR4;XIRP1;MYH11A;KLHL4;SCINLB;PARVG
actin filament bindingFSCN3;ESPN;FLNA;AIF1;EZR;JUB;SHROOM1;VPS16;CTNNA2
calmodulin bindingPHKB;TTN;ARPP21;CAMK1GA;CAMK4;REM1;NETO2;KCNH1;ITPKA
protein heterodimerization activityTGFB1;APITD1;PDSS1;SCUBE1;POLE4;GUCY1A3;HIST1H2AI;P4HB;TRP53
protein homodimerization activityTRIM37;HPRT1;CHMP4B;GCH1;UGT1A1;DMRT2A;APOA2;SRGAP2A;OXA1L
spectrin bindingSPTAN1;UNC13A;GBP1;DCTN2;GNB1;USH1G;EPB49;EPB41;MYO7A

ADD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADD2.

Farghaian, H; Turnley, AM; et al. Bioinformatic Prediction and Confirmation of beta-Adducin as a Novel Substrate of Glycogen Synthase Kinase 3. JOURNAL OF BIOLOGICAL CHEMISTRY 286:25274-25283(2011).
Ogawa, Y; Rasband, MN; et al. Proteomic Analysis of Optic Nerve Lipid Rafts Reveals New Paranodal Proteins. JOURNAL OF NEUROSCIENCE RESEARCH 87:3502-3510(2009).
  • Q&As
  • Reviews

Q&As (10)

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Are there any small molecules or drugs that can selectively modulate the activity or stability of ADD2? 09/20/2022

There may exist small molecules or drugs that selectively modulate the activity or stability of ADD2.

Are there specific interacting proteins or binding partners that associate with ADD2 in a cell- or context-specific manner? 05/19/2021

ADD2 interacts with specific proteins or binding partners, and these interactions can be context-dependent.

What is the expression profile of ADD2 in different tissues and cell types? 04/27/2020

The expression profile of ADD2 varies across different tissues and cell types.

What are the downstream signaling pathways or target molecules regulated by ADD2, and how do they contribute to its cellular functions? 02/16/2020

ADD2 regulates downstream signaling pathways or target molecules that contribute to its cellular functions.

Can specific antibodies or probes be developed to visualize the localization or dynamics of ADD2 in live cells or tissues? 05/07/2019

Specific antibodies or probes can be developed to visualize the localization or dynamics of ADD2 in live cells or tissues.

What post-translational modifications, such as phosphorylation or ubiquitination, occur on ADD2 and how do they impact its function? 02/15/2017

Post-translational modifications, such as phosphorylation or ubiquitination, occur on ADD2 and can influence its function.

Can the functional domains or motifs within ADD2 be identified and characterized? 02/06/2017

Functional domains or motifs within ADD2 can be identified and characterized.

How is the expression of ADD2 regulated during development or in response to specific stimuli? 07/30/2016

The expression of ADD2 can be regulated during development or in response to specific stimuli.

What are the consequences of modulating the expression or activity of ADD2 on cellular processes like cytoskeletal organization, cell motility, or membrane dynamics? 07/15/2016

Modulating the expression or activity of ADD2 can impact cellular processes like cytoskeletal organization, cell motility, or membrane dynamics.

What is the subcellular localization of ADD2 within cells? Does it exhibit any dynamic localization or translocation? 07/07/2016

ADD2 exhibits subcellular localization, and its localization may undergo dynamic changes or translocation.

Customer Reviews (2)

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Reviews
12/07/2021

    Highly sensitive in bioactivity assays, accurately detecting the activity and concentration of bioactive factors.

    05/31/2017

      Provides accurate and reliable quantification of protein biomarkers in clinical samples.

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