Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

ADH7

  • Official Full Name

    alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

  • Overview

    This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants.
  • Synonyms

    ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; alcohol dehydrogenase class 4 mu/sigma chain; ADH 4; ADH 7; ADH4; Alcohol dehydrogenase class IV mu/sigma chain; Gastric alcohol dehydrogenase; Retinol dehydrogenase; alcohol dehydrogenase-7; alcohol dehydrogenase VII; class IV sigma-1 alcohol dehydrogenase; class IV sigmasigma alcohol dehydrogenase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|SUMO
  • MYC
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADH7-3254H Recombinant Human ADH7, His-tagged E.Coli or Yeast His 386
Human ADH7-353H Recombinant Human ADH7 Protein, GST-tagged Wheat Germ GST
Human ADH7-9421H Recombinant Human ADH7, His-tagged E.coli His 253-349a.a.
Human ADH7-20H Recombinant Human ADH7, His-tagged HEK293 His
Human ADH7-9012HCL Recombinant Human ADH7 293 Cell Lysate HEK293 N/A
Human ADH7-308H Recombinant Human ADH7 Protein (1-386 aa), His-tagged E.coli His 1-386 aa
Human ADH7-1318H Recombinant Human ADH7 Protein (1-386 aa), His-tagged Yeast His 1-386 aa
Human ADH7-5336H Recombinant Human ADH7 protein, His-tagged Yeast His 1-386aa
Human ADH7-0250H Recombinant Human ADH7 Protein (G14-F386), Tag Free E.coli No tag G14-F386
Human ADH7-0251H Recombinant Human ADH7 Protein (G14-F386), His tagged E.coli His G14-F386
Human ADH7-943HF Recombinant Full Length Human ADH7 Protein, GST-tagged In Vitro Cell Free System GST 386 amino acids
Human ADH7-0573H Recombinant Human ADH7 Protein (Met1-Phe386 ), C-His-tagged Mammalian cells C-His Met1-Phe386
Mouse ADH7-1357M Recombinant Mouse ADH7 Protein Mammalian Cell His
Mouse ADH7-1927M Recombinant Mouse ADH7 Protein (1-374 aa), His-SUMO-tagged E.coli His/SUMO 1-374 aa
Mouse Adh7-542M Recombinant Mouse Adh7 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Adh7-78M Recombinant Mouse Adh7 Protein, His&GST-tagged E.coli N-His&GST Gly126-Phe374
Mouse ADH7-345M Recombinant Mouse ADH7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ADH7-345M-B Recombinant Mouse ADH7 Protein Pre-coupled Magnetic Beads HEK293
Rat ADH7-526R Recombinant Rat ADH7 Protein Mammalian Cell His
Rat Adh7-3253R Recombinant Rat Adh7, His-tagged E.Coli or Yeast His 374
Rat ADH7-182R Recombinant Rat ADH7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ADH7-182R-B Recombinant Rat ADH7 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ADH7 involved in several pathways and played different roles in them. We selected most pathways ADH7 participated on our site, such as Biological oxidations, Chemical carcinogenesis, Drug metabolism - cytochrome P450, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Biological oxidationsDPEP2;UGT1B2;CYP2R1;SLC35B2;ACY3;ABHD14B;AS3MT;CYP2C19;CYP2AD2
Chemical carcinogenesisSULT1A2;UGT1A7;CYP2A13;CYP2E1;UGT2A1;ADH6;ADH1B;CYP2C9;CYP3A7
Drug metabolism - cytochrome P450ADH1A;CYP2C8;CYP2C19;CYP2B6;CYP3A5;ADH7;CYP2E1;ADH2-1;ADH2-2
Ethanol oxidationADH8B;ADH1A;ADH8A;ADH1B;ADH1C;ADH7;ADH6;ADH5;ADH4
Fatty Acid Omega OxidationADH1B;CYP4A11;ADH1A;CYP2E1;CYP1A1;CYP2D6;ADH7;CYP2A6;ADH1C
Fatty acid degradationALDH1B1;ALDH2;ACADM;CYP4A12A;ADH5;ALDH2.1;CPT2;CPT1B;ACSL1A
Glycolysis / GluconeogenesisADPGK;ENO2;ALDH1A3;ADH6;PDHA2;LDHAL6A;PGAM1;AKR1A1B;PKM2
Metabolic pathwaysCMASA;ALPL;ADH4;IDH3B;COQ6;MTMR1B;PCCB;TKT;NANP

ADH7 has several biochemical functions, for example, alcohol dehydrogenase (NAD) activity, alcohol dehydrogenase activity, zinc-dependent, aldehyde oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH7 itself. We selected most functions ADH7 had, and list some proteins which have the same functions with ADH7. You can find most of the proteins on our site.

Function Related Protein
alcohol dehydrogenase (NAD) activityADH4;ADH1A;ADH5;ADH6;ADH1C;DHRS9;ADH8A;ADH8B;ADH1
alcohol dehydrogenase activity, zinc-dependentADH7;ADH4;ADH1B;ADH1A
aldehyde oxidase activityAOX1;AOX4;ADH7;AOX3;AOX3L1
ethanol bindingADH1;ADH7;ADH4;PRKCE
receptor antagonist activityLRPAP1;DKK1;IL18BP;ESR2;AGTR2;ADH7
retinol bindingADH7;RLBP1;RBP7;RBP3;C8G;RBP4;RBP1;RBP5;CRABP2
retinol dehydrogenase activityHSD17B6;ADH4;RDH8;RDH5;ADH7;RDH11;DHRS7C;SDR9C7;RDH12
zinc ion bindingISL2;SIRT5;ADAM8A;MMP14A;UBR3;NSD1;ADH7;RNF13;BHMT2

ADH7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH7.

  • Q&As
  • Reviews

Q&As (10)

Ask a question
Are there any specific interacting partners or cofactors that modulate the activity or function of ADH7, and what are the underlying molecular mechanisms? 02/11/2022

ADH7 can interact with specific partners or cofactors that modulate its activity or function, and studying the underlying molecular mechanisms elucidates its regulatory mechanisms.

Are there any known genetic variations or polymorphisms in the ADH7 gene associated with altered alcohol metabolism or susceptibility to alcohol-related disorders? 11/05/2020

Genetic variations or polymorphisms in the ADH7 gene may impact alcohol metabolism and susceptibility to alcohol-related disorders, emphasizing the role of genetic factors in its function.

Can ADH7 activity be modulated by pharmacological agents or environmental factors, and are there potential therapeutic implications? 08/16/2020

ADH7 activity may be modulated by pharmacological agents or environmental factors, suggesting potential therapeutic implications and the possibility of targeting ADH7 in treatment strategies.

How does ADH7 expression and activity change in response to different alcohol concentrations or exposure durations, and what are the molecular mechanisms underlying these changes? 03/18/2020

ADH7 expression and activity can change in response to varying alcohol concentrations or exposure durations, and understanding the molecular mechanisms involved enhances our knowledge of alcohol-related effects.

How is ADH7 expression regulated at the transcriptional and post-transcriptional levels, and are there any specific factors or signaling pathways involved? 08/08/2019

ADH7 expression is regulated at the transcriptional and post-transcriptional levels by various factors and signaling pathways, providing insights into its regulation.

What is the tissue-specific expression pattern of ADH7, and how does it compare to the expression patterns of other ADH isoforms? 07/14/2019

ADH7 exhibits a tissue-specific expression pattern, which may differ from other ADH isoforms, highlighting its unique role in specific tissues.

What is the impact of ADH7 deficiency or overexpression on alcohol metabolism and its physiological consequences? 07/03/2019

Exploring the consequences of ADH7 deficiency or overexpression provides insights into its role in alcohol metabolism and its impact on physiological processes related to alcohol-related disorders.

Can ADH7 metabolize other endogenous compounds or xenobiotics besides alcohol, and if so, what are the implications for its broader physiological functions? 02/12/2018

ADH7 may participate in the metabolism of other endogenous compounds or xenobiotics, suggesting its involvement in broader physiological functions beyond alcohol metabolism.

What are the enzymatic kinetics and substrate specificity of ADH7, and how do they contribute to its function in alcohol metabolism? 08/22/2017

The enzymatic kinetics and substrate specificity of ADH7 contribute to its function in alcohol metabolism, enabling efficient conversion of specific alcohol substrates.

What are the structural features of ADH7, and how do they relate to its catalytic activity and binding properties? 05/01/2017

Investigating the structural features of ADH7 provides valuable information on its catalytic activity and binding properties, aiding in understanding its function.

Customer Reviews (2)

Write a review
Reviews
07/23/2019

    Highly specific in recognizing and binding to target antigens in immunodiagnostic assays.

    02/26/2016

      Exhibits excellent resistance to thermal denaturation in thermal shift assays.

      Ask a Question for All ADH7 Products

      Required fields are marked with *

      My Review for All ADH7 Products

      Required fields are marked with *

      logo

      FOLLOW US

      Terms and Conditions        Privacy Policy

      Copyright © 2024 Creative BioMart. All Rights Reserved.

      Contact Us

      • /

      Stay Updated on the Latest Bioscience Trends